Recombinant Human CYP2D6 Protein, DDK-tagged
Cat.No. : | CYP2D6-3401H |
Product Overview : | Recombinant Human CYP2D6 protein, fused to DDK-tagged at C-terminus, was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at -80 Centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. |
Molecular Mass : | 57 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 [ Homo sapiens ] |
Official Symbol : | CYP2D6 |
Synonyms : | CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1 |
Gene ID : | 1565 |
mRNA Refseq : | NM_000106 |
Protein Refseq : | NP_000097 |
MIM : | 124030 |
UniProt ID : | P10635 |
Products Types
◆ Recombinant Protein | ||
CYP2D6-78H | Active Recombinant Human CYP2D6 Protein | +Inquiry |
CYP2D6-0004H | Recombinant Human CYP2D6 Protein (P34-R497), His tagged | +Inquiry |
CYP2D6-703H | Recombinant Human CYP2D6 Protein, His (Fc)-Avi-tagged | +Inquiry |
CYP2D6-0003H | Recombinant Human CYP2D6 Protein (P34-R497), Tag Free | +Inquiry |
CYP2D6-978R | Recombinant Rhesus Macaque CYP2D6 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CYP2D6-7112HCL | Recombinant Human CYP2D6 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2134 | Cytochrome P450 2D6 Fluorometric Activity Assay Kit | +Inquiry |
Kit-2135 | Cytochrome P450 2D6 Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket