cysltr1
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  • Official Full Name
  • cysteinyl leukotriene receptor 1
  • Background
  • The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
  • Synonyms
  • CYSLTR1; cysteinyl leukotriene receptor 1; CysLT(1); CysLT1; CYSLT1R; CYSLT 1; CYSLTR 1; CYSLTR; CysLTR vide supra; Cysteinyl leukotriene D4 receptor; HG55; HMTMF81; LTD4 receptor; MGC46139; G-protein coupled receptor HG55
Cat.#:CYSLTR1-2299HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYSLTR1 Protein
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Cat.#:CYSLTR1-2300HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYSLTR1 Protein, GST-tagged
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Cat.#:CYSLTR1-4248MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYSLTR1 Protein
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Cat.#:CYSLTR1-1760RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYSLTR1 Protein
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Cat.#:CYSLTR1-2820ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CYSLTR1
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Cat.#:CSC-RG0281Tag:
Source (Host):Species:Human
Product nameHuman CYSLTR1-FLAG Stable Cell Line-HEK293T
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Cat.#:CSC-RG0680Tag:
Source (Host):Species:Human
Product nameHuman CYSLTR1/Galpha15 Stable Cell Line-Chem-1
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Involved Pathway

CYSLTR1 involved in several pathways and played different roles in them. We selected most pathways CYSLTR1 participated on our site, such as Calcium signaling pathway, Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYSLTR1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
VDAC1; CCKBR; CD38; TNNC1; PPIF; PHKA2; NTSR1; PLCG2; PTGER1C; TACR2
Class A/1 (Rhodopsin-like receptors)
PPY; PROK1; PYYA; AGTR2; RLN3A; CCL27; APLNR; SSTR3; GPR18; RXFP2
Eicosanoid ligand-binding receptors
LTB4R; OXER1; GPR17; PTGDR2; CYSLTR1
Endothelins
EDNRB; CYSLTR1; COL1A2; COL3A1; EDN1; EDN3; EDN2; EDNRA
G alpha (q) signalling events
GPR68; ANXA1C; AGTR1; CYSLTR1; PROK2; CASR; RGS19; DGKB; RASGRP2; GRP
GPCR downstream signaling
PENK; NMS; CHRM4; RAMP3; OPN1LW2; ANXA1C; VIP2; OPN1LW; DGKB; GNA13
GPCR ligand binding
GAL; GPR65; GPR132; PROK1; SETD6; OPN5; NMB; GCGB; CHRM5; PENKA
GPCRs, Class A Rhodopsin-like
CCR3; CYSLTR1; ADORA1; SSTR3; OPN1SW; FPR-RS3; CNR2; GPR32; GPR77; ADORA3

Protein Function

CYSLTR1 has several biochemical functions, for example, G-protein coupled peptide receptor activity, cysteinyl leukotriene receptor activity, leukotriene receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYSLTR1 itself. We selected most functions CYSLTR1 had, and list some proteins which have the same functions with CYSLTR1. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled peptide receptor activity
Related Protein CYSLTR1; FSHR; MC1R; LTB4R; GPR84; NPR1; MCHR2; GPR37; RXFP3; LTB4R2
Function cysteinyl leukotriene receptor activity
Related Protein MCHR2; CYSLTR2; CYSLTR1
Function leukotriene receptor activity
Related Protein LTB4R2; LTB4R; CYSLTR1; CYSLTR2
Function protein binding
Related Protein IQCB1; PHYH; CBR4; FIP1L1; CHP; CBFA2T2; CXCR4; RPP25L; UBXN8; PDLIM4

Interacting Protein

CYSLTR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYSLTR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYSLTR1.
CYSLTR2

CYSLTR1 Related Articles

Cosentino, S; Castiglioni, L; et al. Expression of dual Nucleotides/Cysteinyl-Leukotrienes Receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:1785-1796(2014).
Kawakami, Y; Hirano, S; et al. Neutralization of leukotriene C-4 and D-4 activity by monoclonal and single-chain antibodies. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1840:1625-1633(2014).