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Official Full Name cysteinyl leukotriene receptor 1
Background The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
Synonyms CYSLTR1; cysteinyl leukotriene receptor 1; CysLT(1); CysLT1; CYSLT1R; CYSLT 1; CYSLTR 1; CYSLTR; CysLTR vide supra; Cysteinyl leukotriene D4 receptor; HG55; HMTMF81; LTD4 receptor; MGC46139; G-protein coupled receptor HG55
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYSLTR1-2299H Recombinant Human CYSLTR1 Protein Wheat Germ N/A
    Human CYSLTR1-2300H Recombinant Human CYSLTR1 Protein, GST-tagged Wheat Germ GST
    Mouse CYSLTR1-4248M Recombinant Mouse CYSLTR1 Protein Mammalian Cell His
    Rat CYSLTR1-1760R Recombinant Rat CYSLTR1 Protein Mammalian Cell His
    Zebrafish CYSLTR1-2820Z Recombinant Zebrafish CYSLTR1 Mammalian Cell His

    CYSLTR1 involved in several pathways and played different roles in them. We selected most pathways CYSLTR1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYSLTR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway ERBB4A; CAMK2A; PLCB4; ADRB3; SLC8A1A; CYSLTR2; PPP3CA; TACR3A; ITPKB; ITPKC
    Class A/1 (Rhodopsin-like receptors) EDNRAB; KEL; XK; PROK2; TAC3; OPN5; RLN2; FPR-RS6; CXCR6; CNR1
    Eicosanoid ligand-binding receptors CYSLTR1; OXER1; PTGDR2; GPR17; LTB4R
    Endothelins COL3A1; EDN2; CYSLTR1; COL1A2; EDNRB; EDN1; EDNRA; EDN3
    G alpha (q) signalling events APPB; ADRA1D; PROKR2; EDN3; GPR132; NMU; APPA; QRFPR; NMUR1; GCGB
    GPCR downstream signaling ANXA1C; TAC3; ADORA3; CCL19A.2; PNOC; OPN1LW1; GNA13B; NPFFR2; CXCL11.8; NTS
    GPCR ligand binding CCL35.1; CXCR7B; APLNR; ADCYAP1B; ZFPM2B; FPR-RS4; GNB5B; APLN; EDN2; S1PR3
    GPCRs, Class A Rhodopsin-like CNR2; SSTR5; GPR45; OPN1SW; OR10A5; CCRL2; SSTR1; AGTR2; SSTR3; OPN1LW

    CYSLTR1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CYSLTR1 itself. We selected most functions CYSLTR1 had, and list some proteins which have the same functions with CYSLTR1. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled peptide receptor activity GPR84; RXFP3.2B; NPR1; GRPR; MCHR2; GPR37; GPR37L1; TSHR; CYSLTR1; RXFP3
    cysteinyl leukotriene receptor activity MCHR2; CYSLTR1; CYSLTR2
    leukotriene receptor activity CYSLTR1; CYSLTR2; LTB4R2; LTB4R
    protein binding CCDC108; CSRP2; DTX3L; EIF3M; U2AF1; LATS2; CNOT6L; BCL2L16; PKMYT1; BMP2

    CYSLTR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYSLTR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYSLTR1.


    Cosentino, S; Castiglioni, L; et al. Expression of dual Nucleotides/Cysteinyl-Leukotrienes Receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:1785-1796(2014).
    Kawakami, Y; Hirano, S; et al. Neutralization of leukotriene C-4 and D-4 activity by monoclonal and single-chain antibodies. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1840:1625-1633(2014).

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