cry1
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  • Official Full Name
  • cryptochrome 1 (photolyase-like)
  • Background
  • Cryptochromes (from the Greek κρυπτ? χρ?μα, hidden colour) are a class of blue light-sensitive flavoproteins found in plants and animals. Cryptochromes are involved in the circadian rhythms of plants and animals, and in the sensing of magnetic fields in a number of species. The name Cryptochrome was proposed as a pun combining the cryptic nature of the photoreceptor, and the cryptogamic organisms on which many blue light studies were carried out. The two genes Cry1 and Cry2 code for the two cryptochrome proteins CRY1 and CRY2. In insects and plants, CRY1 regulates the circadian clock in a light-dependent fashion, whereas in mammals, CRY1 and CRY2 act as light-independent inhibitors of CLOCK-BMAL1 components of the circadian clock. In plants, blue light photoreception can be used to cue developmental signals
  • Synonyms
  • CRY1; cryptochrome 1 (photolyase-like); PHLL1; cryptochrome-1; photolyase-like cryptochrome 1
Cat.#:CRY1-1922HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CRY1 Protein, GST-tagged
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Cat.#:CRY1-639HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRY1 Protein, His/GST-tagged
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Cat.#:CRY1-11596HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRY1, His-tagged
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Cat.#:CRY1-26414THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CRY1
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Cat.#:CRY1-7269HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CRY1 protein, MYC/DDK-tagged
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Cat.#:CRY1-3931MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CRY1 Protein
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Cat.#:CRY1-1608RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CRY1 Protein
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Cat.#:CRY1-1036RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CRY1 Protein, His-tagged
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Cat.#:CRY1-5818CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CRY1
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Cat.#:CRY1-7269HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CRY1 293 Cell Lysate
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Involved Pathway

Cry1 involved in several pathways and played different roles in them. We selected most pathways Cry1 participated on our site, such as BMAL1:CLOCK,NPAS2 activates circadian gene expression, Circadian Clock, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cry1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BMAL1:CLOCK,NPAS2 activates circadian gene expression
NAMPT; CREBBP; CRY1; NRIP1; CRY2; NCOA2; HELZ2; DBP; CARM1
Circadian Clock
DBP; CSNK1E; CARM1; CPT1A; NRIP1; HELZ2; CRY1; RAI1; CRY2; NAMPT
Circadian rhythm
ARNTL; CSNK1E; CLOCK; PRKAG3; RORA; PRKAA2; PER2; FBXL3; RBX1; CRY2
Diurnally regulated genes with circadian orthologs
ZFR; CRY1; AZIN1; ERC2; KLF9; ITM2B; SF3A3; NCKAP1; CEBPB; GFRA1

Protein Function

Cry1 has several biochemical functions, for example, NOT DNA (6-4) photolyase activity, DNA binding, blue light photoreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cry1 itself. We selected most functions Cry1 had, and list some proteins which have the same functions with Cry1. You can find most of the proteins on our site.
Function
Related Protein
Function NOT DNA (6-4) photolyase activity
Related Protein CRY1; CRY2
Function DNA binding
Related Protein NPAS4A; MAFBB; ZBED5; ZFP687; CHRAC1; ING2; CROP; HIST1H101; TIGD6; FOSB
Function blue light photoreceptor activity
Related Protein CRY1; CRY2
Function core promoter binding
Related Protein MTF1; REST; NEUROG3; NKX2-1; CCAR1; E2F7; CRY1; HDAC2; SFPI1; HNRNPU
Function core promoter sequence-specific DNA binding
Related Protein KLF10; C1orf51; SOHLH1; NR1D2; NRF1; TOP1; ZFP750; RORA; H2AFY; THRAP3
Function NOT deoxyribodipyrimidine photo-lyase activity
Related Protein CRY1; CRY2
Function double-stranded DNA binding
Related Protein RAD51B; XRCC6; AFF3; XRCC3; GTF2H4; FBXO18; FEV; SP1; MRE11A; LSM14A
Function histone deacetylase binding
Related Protein PRDM1; KPNA2; D7ERTD443E; SOD3; SKOR2; HIST1H1B; TCF21; HDAC4; CCND1; CRY1
Function nuclear hormone receptor binding
Related Protein MYOD1; NCOA3; NCOA2; EP300; ACTN4; NRIP1; NCOR1; BUD31; TACC2; CRX
Function nucleotide binding
Related Protein SMOK2B; RBM15B; ABCA6; CHD1L; LRGUK; THOC4; CPEB2; CPSF6; CHD8; NT5C1B
Function phosphatase binding
Related Protein CARHSP1; DLG3; TRPC4AP; CSRNP2; SH3YL1; PPP1R32; TPRN; KIAA0649; SH3RF2; MAPK1
Function protein binding
Related Protein MAP2K2; TIMM50; SPSB2; ITM2B; NOX1; MCCC1; PRKCA; FRMD8; CCPG1; GSTM4
Function protein kinase binding
Related Protein MLKL; DCX; GDF3; NEK9; WAS; KIF14; TNNI3; MAPK6; GSK3B; CDK5RAP1
Function transcription factor activity, transcription factor binding
Related Protein ASCL1B; MTA2; TP63; NEUROG1; HIF1A; LDB1A; PER1; PER2; LDB1B; LDB2B
Function transcription factor binding
Related Protein EPN1; TAF7; FOXA3; MED6; HHEX; UBN1; SMAD2; MED12L; ESRRB; ARNT
Function ubiquitin binding
Related Protein RNF168; SHRPRBCK1R; USP13; UCHL3; RBCK1; DYRK2; OTUB2; CXCR4; SQSTM1; BRAP

Interacting Protein

Cry1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cry1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cry1.
PLSCR1; CSNK1E; Cry1; Csnk1e; Timeless; GRN; SNRPD3; TRAF2; CBLB; LTBP4; MDFI; KRTAP4-12; Psmb5; SYNCRIP; BAG6; JAK3; Sesn2; Esrrb

Cry1 Related Articles

Sha, S; Yin, Y; et al. A New Method for Immobilizing Antibody Probes in Immunochips Based on DNA Hybridization. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 41:199-204(2013).
Watari, R; Yamaguchi, C; et al. Light-dependent Structural Change of Chicken Retinal Cryptochrome4. JOURNAL OF BIOLOGICAL CHEMISTRY 287:42634-42641(2012).