dctn2
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  • Official Full Name
  • dynactin 2 (p50)
  • Background
  • This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.
  • Synonyms
  • DCTN2; dynactin 2 (p50); dynactin subunit 2; DCTN 50; RBP50; p50 dynamitin; dynactin complex 50 kD subunit; dynactin complex 50 kDa subunit; 50 kD dynein-associated polypeptide; 50 kDa dynein-associated polypeptide; DCTN50; DYNAMITIN
Cat.#:DCTN2-2411HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DCTN2 Protein, GST-tagged
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Cat.#:DCTN2-2439HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human DCTN2, His-tagged
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Cat.#:DCTN2-2450HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human DCTN2, His-tagged
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Cat.#:DCTN2-2490HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human DCTN2, His-tagged
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Cat.#:DCTN2-26061THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCTN2, His-tagged
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Cat.#:DCTN2-1801RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DCTN2 Protein
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Cat.#:DCTN2-6365CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DCTN2
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Cat.#:DCTN2-11383ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DCTN2
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Cat.#:DCTN2-7042HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DCTN2 293 Cell Lysate
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Involved Pathway

DCTN2 involved in several pathways and played different roles in them. We selected most pathways DCTN2 participated on our site, such as Adaptive Immune System, Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
FBXO3; TRIM11; AGO3; KIF3A; DCTN3; LAIR1; NA; EGF; NPEPPS; RNF144B
Anchoring of the basal body to the plasma membrane
SDCCAG8; SSNA1; NDE1; DCTN3; IQCB1; CEP70; CEP135; TCTN3; TUBB4B; MKS1
Assembly of the primary cilium
NPHP4; RABL5; WDR19; CETN2; BBS12; BBS4; CLASP1; CEP152; BBS13; TUBG1
Cell Cycle
ORC2L; ESPL1; E2F4; CDC25B; YWHAE1; SMAD3A; RAD9; SUN1; ATM; CUL1B
Cell Cycle, Mitotic
SPC25; CLASP1A; VRK1; E2F3; PDS5B; DYRK1A; NUP50; ACTR1A; NUF2; TCTN2
Centrosome maturation
CEP290; TUBG2; PLK4; ODF2; TUBGCP5; OFD1; TSGA14; CEP72; CEP57; DCTN1
G2/M Transition
FOXM1; ACTR1A; TUBGCP5; CLASP1; CEP78; LIN9; CDK11A; CEP152; ODF2; CDK11B
Huntingtons disease
NDUFA2; CASP9; IFT57; DCTN2; CREB3L2; NDUFA4L2; Casp3; COX7A2L; POLR2D; NDUFS7

Protein Function

DCTN2 has several biochemical functions, for example, motor activity, protein binding, spectrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCTN2 itself. We selected most functions DCTN2 had, and list some proteins which have the same functions with DCTN2. You can find most of the proteins on our site.
Function
Related Protein
Function motor activity
Related Protein MYO7B; KIF1C; VMHCL; DYNLT3; KIF2A; MYO5A; DNAIC2; MYH8; MYH11A; MYHZ1.1
Function protein binding
Related Protein NTSR1; ITPKB; IVL; ZFP932; C4BPB; CENPI; KCNE1L; IFT88; AGTRAP; GABBR2
Function spectrin binding
Related Protein ADD1; MYO7A; SPTAN1; CAMSAP1L1; PDE6G; DCTN2; USH1C; CAMSAP1; PTPRN; ANK1

Interacting Protein

DCTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCTN2.
CCDC172; HAUS1; KIFC3; BLOC1S6; GADD45A; Dctn1; IKBKE; EGFR; GNAO1; p29991-pro_0000308465