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Official Full Name DNA fragmentation factor, 45kDa, alpha polypeptide
Background Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms DFFA; DNA fragmentation factor, 45kDa, alpha polypeptide; DFF1; ICAD; DFF-45; DNA fragmentation factor subunit alpha; DFF45; inhibitor of CAD; DNA fragmentation factor 45 kDa subunit;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DFFA-2555H Recombinant Human DFFA Protein, GST-tagged Wheat Germ GST
    Human DFFA-27566TH Recombinant Human DFFA, His-tagged E.coli His
    Human DFFA-28396TH Recombinant Human DFFA, His-tagged E.coli His
    Human DFFA-4316H Recombinant Human DNA Fragmentation Factor, 45kDa, Alpha Polypeptide, His-tagged Human His
    Human DFFA-488H Recombinant Human DFFA E.coli N/A
    Human DFFA-6967HCL Recombinant Human DFFA 293 Cell Lysate HEK293 N/A
    Mouse Dffa-1836M Recombinant Mouse Dffa protein, His & T7-tagged E.coli His/T7
    Mouse DFFA-4531M Recombinant Mouse DFFA Protein Mammalian Cell His
    Rhesus Macaque DFFA-1249R Recombinant Rhesus monkey DFFA Protein, His-tagged Mammalian Cell His
    Zebrafish DFFA-742Z Recombinant Zebrafish DFFA Mammalian Cell His

    DFFA involved in several pathways and played different roles in them. We selected most pathways DFFA participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with DFFA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of DNA fragmentation factor HMGB2A; HIST1H1E; HIST1H1A; HIST1H1D; H1F0; HMGB2; HIST1H1B; DFFA; HIST1H1C
    Apoptosis PIK3R3; GAS2; MAP3K14; IL1R1; PPP3R2; BNIP3L; DCC; PANK1A; ADD1; BID
    Apoptosis Modulation and Signaling CAPNS1; BAG3; SEPT4; CRADD; BIK; DIABLO; DAXX; CASP2; BCL2L11; HRK
    Apoptosis induced DNA fragmentation DFFA; HMGB2A; HIST1H1D; HIST1H1A; HIST1H1E; HIST1H1C; H1F0; HMGB2; HIST1H1B
    Apoptotic execution phase H1F0; HMGB2; DSG3; STK24B; HIST1H1B; HIST1H1D; DSP; VIML; DBNLA; BCAP31
    Caspase cascade in apoptosis PARP1; TFAP2A; SATB1; DIABLO; CFL2; LMNB1; CASP4; NUMA1; ACTA1; GAS2
    FAS pathway and Stress induction of HSP regulation LMNB2; FAF1; DAXX; DFFA
    HIV-1 Nef: Negative effector of Fas and TNF-alpha DFFA; CRADD; DAXX; CASP2

    DFFA has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by DFFA itself. We selected most functions DFFA had, and list some proteins which have the same functions with DFFA. You can find most of the proteins on our site.

    Function Related Protein
    protein binding C4orf19; UPF1; KPNA3; SH2D2A; ZHX3; ETV4; GNAQ; KRIT1; RUSC1; CLK2

    DFFA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DFFA here. Most of them are supplied by our site. Hope this information will be useful for your research of DFFA.

    DFFB; YWHAG; YWHAZ; HSPB1; Dffb; 7460242

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