|Official Full Name||DNA fragmentation factor, 45kDa, alpha polypeptide|
|Background||Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]|
|Synonyms||DFFA; DNA fragmentation factor, 45kDa, alpha polypeptide; DFF1; ICAD; DFF-45; DNA fragmentation factor subunit alpha; DFF45; inhibitor of CAD; DNA fragmentation factor 45 kDa subunit;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
DFFA involved in several pathways and played different roles in them. We selected most pathways DFFA participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with DFFA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Activation of DNA fragmentation factor||HMGB2A; HIST1H1E; HIST1H1A; HIST1H1D; H1F0; HMGB2; HIST1H1B; DFFA; HIST1H1C|
|Apoptosis||PIK3R3; GAS2; MAP3K14; IL1R1; PPP3R2; BNIP3L; DCC; PANK1A; ADD1; BID|
|Apoptosis Modulation and Signaling||CAPNS1; BAG3; SEPT4; CRADD; BIK; DIABLO; DAXX; CASP2; BCL2L11; HRK|
|Apoptosis induced DNA fragmentation||DFFA; HMGB2A; HIST1H1D; HIST1H1A; HIST1H1E; HIST1H1C; H1F0; HMGB2; HIST1H1B|
|Apoptotic execution phase||H1F0; HMGB2; DSG3; STK24B; HIST1H1B; HIST1H1D; DSP; VIML; DBNLA; BCAP31|
|Caspase cascade in apoptosis||PARP1; TFAP2A; SATB1; DIABLO; CFL2; LMNB1; CASP4; NUMA1; ACTA1; GAS2|
|FAS pathway and Stress induction of HSP regulation||LMNB2; FAF1; DAXX; DFFA|
|HIV-1 Nef: Negative effector of Fas and TNF-alpha||DFFA; CRADD; DAXX; CASP2|
DFFA has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by DFFA itself. We selected most functions DFFA had, and list some proteins which have the same functions with DFFA. You can find most of the proteins on our site.
|protein binding||C4orf19; UPF1; KPNA3; SH2D2A; ZHX3; ETV4; GNAQ; KRIT1; RUSC1; CLK2|
DFFA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DFFA here. Most of them are supplied by our site. Hope this information will be useful for your research of DFFA.
DFFB; YWHAG; YWHAZ; HSPB1; Dffb; 7460242