dgcr8
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  • Official Full Name
  • DGCR8 microprocessor complex subunit
  • Background
  • This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
  • Synonyms
  • DGCR8; DGCR8 microprocessor complex subunit; Gy1; pasha; DGCRK6; C22orf12; microprocessor complex subunit DGCR8; DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8;
Cat.#:DGCR8-2567HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DGCR8 Protein, GST-tagged
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Cat.#:DGCR8-4541MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DGCR8 Protein
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Cat.#:DGCR8-1252RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DGCR8 Protein, His-tagged
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Cat.#:DGCR8-6587ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DGCR8
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Cat.#:DGCR8-6962HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DGCR8 293 Cell Lysate
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Involved Pathway

DGCR8 involved in several pathways and played different roles in them. We selected most pathways DGCR8 participated on our site, such as Direct p53 effectors, Gene Expression, Gene Silencing by RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGCR8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Direct p53 effectors
CCNK; BCL2L14; DGCR8; EPHA2; PLK3; CTSD; DDX5; RNF144B; FDXR; HIC1
Gene Expression
MADD; MED8; PRDX2; ZNF461; ZNF285A; HIPK1; TRIM33; NR2F6A; DDX6; ZFP36L1
Gene Silencing by RNA
MYBL1; MAEL; EIF2C3; DPY19L2; FKBP6; PIWIL4; PLD6; TSN; TARBP2; BARHL1
MicroRNA (miRNA) biogenesis
DGCR8; TARBP2; BARHL1

Protein Function

DGCR8 has several biochemical functions, for example, double-stranded RNA binding, heme binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DGCR8 itself. We selected most functions DGCR8 had, and list some proteins which have the same functions with DGCR8. You can find most of the proteins on our site.
Function
Related Protein
Function double-stranded RNA binding
Related Protein ZFP346; OAS1; STAU2; DHX36; DGCR8; DDX21; RFTN1; CLTC; OASL; HSPD1
Function heme binding
Related Protein CBS; HRG; CYP2AA12; EIF2AK1; CYP2AA8; CYP2B19; CYP4F12; CYP1A1; CYP2AA2; CYP2X7
Function metal ion binding
Related Protein MORC4; TPH1B; XGB; USP19; RPE65; CYP4A14; KLF2A; ACSM2B; ACAN; MAP2K2
Function primary miRNA binding
Related Protein DGCR8; SRF
Function protein binding
Related Protein CTCF; SCNN1B; CREBBP; INMT; GNB5; ITGB3; AAK1; PIK3R1; KIAA1191; NEK2
Function protein homodimerization activity
Related Protein PYGL; MAP3K13; MGLL; NTSR1; ERBB4; ANXA6; G6PDX; DAXX; MYOM1; GABPB2
Function contributes_to ribonuclease III activity
Related Protein DGCR8

Interacting Protein

DGCR8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGCR8 here. Most of them are supplied by our site. Hope this information will be useful for your research of DGCR8.
DROSHA; SRPK1; MEOX2; DDX17; EEF1D; HNRNPUL1; KIF15