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DISC1

  • Official Full Name

    disrupted in schizophrenia 1

  • Overview

    interacts with a variety of cytoskeletal proteins; truncated mutant form is associated with Schizophrenia
  • Synonyms

    DISC1; disrupted in schizophrenia 1; disrupted in schizophrenia 1 protein; SCZD9; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DISC1-6918HCL Recombinant Human DISC1 293 Cell Lysate HEK293 N/A
Human DISC1-766H Recombinant Human DISC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DISC1-6678H Recombinant Human DISC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DISC1-470H Recombinant Human DISC1 Protein, His-tagged E.coli His Ser102~Cys261
Human DISC1-661HFL Active Recombinant Full Length Human DISC1 Protein, C-Flag-tagged Mammalian cells Flag
Human DISC1-766H-B Recombinant Human DISC1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Disc1-471M Recombinant Mouse Disc1 Protein, His-tagged E.coli His Ser151~Leu330
Mouse Disc1-2571M Recombinant Mouse Disc1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat DISC1-1873R Recombinant Rat DISC1 Protein Mammalian Cell His
Rat Disc1-472R Recombinant Rat Disc1 Protein, His-tagged E.coli His Glu151~Gln340
Rat DISC1-1531R-B Recombinant Rat DISC1 Protein Pre-coupled Magnetic Beads HEK293
Rat DISC1-1531R Recombinant Rat DISC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DISC1-1271R Recombinant Rhesus monkey DISC1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DISC1-1096R Recombinant Rhesus Macaque DISC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DISC1-1096R-B Recombinant Rhesus Macaque DISC1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DISC1-7233Z Recombinant Zebrafish DISC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DISC1 Related Articles
  • DISC1 Related Research Area

DISC1 involved in several pathways and played different roles in them. We selected most pathways DISC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DISC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DISC1 has several biochemical functions, for example, kinesin binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DISC1 itself. We selected most functions DISC1 had, and list some proteins which have the same functions with DISC1. You can find most of the proteins on our site.

Function Related Protein
kinesin bindingSERPINB1A;SNCA;NEFH;KIFAP3A;JIP1;KIF18B;TOR1A;CLSTN1;SPAG9
protein bindingHLA-DOA;UPRT;KLRB1F;PSMD3;RERG;BRD2;SORL1;ABCD2;CXCR7
protein complex bindingCtsl;RARB;AP2B1;CDKN1A;NASP;DAG1;THRA;YWHAB;CDK2
protein complex scaffoldDISC1;KLHL17;MAGI1;WWC1;SLC9A3R1;AKAP9;WWC3;CAV1;CAV2

DISC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DISC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DISC1.

PCNT; TRAF3IP1; NDEL1

Bradshaw, NJ; Bader, V; et al. Aggregation of the Protein TRIOBP-1 and Its Potential Relevance to Schizophrenia. PLOS ONE 9:-(2014).
El-Hassar, L; Simen, AA; et al. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. BIOLOGICAL PSYCHIATRY 76:476-485(2014).
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