Active Recombinant Full Length Human DISC1 Protein, C-Flag-tagged

• Cat.No.: DISC1-661HFL
• Product Overview: Recombinant Full Length Human DISC1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: ELISA binding assay
• Molecular Mass: 93.4 kDa
• AA Sequence: MPGGGPQGAPAAAGGGGVSHRAGSR DCLPPAACFRRRRLARRPGYMRSST GPGIGFLSPAVGTLFRFPGG VSGEESHHSESRARQCGLDSRGLLV RSPVSKSAAAPTVTSVRGTSAHFGI QLRGGTRLPDRLSWPCGPGS AGWQQEFAAMDSSETLDASWEAACS DGARRVRAAGSLPSAELSSNSCSPG CGPEVPPTPPGSHSAFTSSF SFIRLSLGSAGERGEAEGCPPSREA ESHCQSPQEMGAKAASLDGPHEDPR CLSRPFSLLATRVSADLAQA ARNSSRPERDMHSLPDMDPGSSSSL DPSLAGCGGDGSSGSGDAHSWDTLL RKWEPVLRDCLLRNRRQMEV ISLRLKLQKLQEDAVENDDYDKAET LQQRLEDLEQEKISLHFQLPSRQPA LSSFLGHLAAQVQAALRRGA TQQASGDDTHTPLRMEPRLLEPTAQ DSLHVSITRRDWLLQEKQQLQKEIE ALQARMFVLEAKDQQLRREI EEQEQQLQWQGCDLTPLVGQLSLGQ LQEVSKALQDTLASAGQIPFHAEPP ETIRSLQERIKSLNLSLKEI TTKVCMSEKFCSTLRKKVNDIETQL PALLEAKMHAISGNHFWTAKDLTEE IRSLTSEREGLEGLLSKLLV LSSRNVKKLGSVKEDYNRLRREVEH QETAYETSVKENTMKYMETLKNKLC SCKCPLLGKVWEADLEACRL LIQSLQLQEARGSLSVEDERQMDDL EGAAPPIPPRLHSEDKRKTPLKVLE EWKTHLIPSLHCAGGEQKEE SYILSAELGEKCEDIGKKLLYLEDQ LHTAIHSHDEDLIQSLRRELQMVKE TLQAMILQLQPAKEAGEREA
  AASCMTAGVHEAQATRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: DISC1 DISC1 scaffold protein [ Homo sapiens (human) ]
• Official Symbol: DISC1
• Synonyms: SCZD9; C1orf136
• Gene ID: 27185
• mRNA Refseq: NM_018662.3
• Protein Refseq: NP_061132.2
• MIM: 605210
• UniProt ID: Q9NRI5