Recombinant Human DISC1 Protein, His-tagged

• Cat.No.: DISC1-470H
• Product Overview: Recombinant Human DISC1(Ser102~Cys261) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 20.2kDa
• Protein length: Ser102~Cys261
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: DISC1 disrupted in schizophrenia 1 [ Homo sapiens ]
• Official Symbol: DISC1
• Synonyms: DISC1; disrupted in schizophrenia 1; disrupted in schizophrenia 1 protein; SCZD9; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457
• Gene ID: 27185
• mRNA Refseq: NM_001012957
• Protein Refseq: NP_001012975
• MIM: 605210
• UniProt ID: Q9NRI5