dnaja2
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  • Official Full Name
  • DnaJ (Hsp40) homolog, subfamily A, member 2
  • Background
  • The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro.
  • Synonyms
  • DNAJA2; DnaJ (Hsp40) homolog, subfamily A, member 2; dnaJ homolog subfamily A member 2; CPR3; DNAJ; DNJ3; HIRIP4; Cell cycle progression 3 protein; Cell cycle progression restoration gene 3 protein; CPR 3; Dj3; DJA 2; DJA2; DnaJ (Hsp40) homolog subfamily A member 2; DNAJA 2; DNJ 3; DNJA2_HUMAN; HIRA interacting protein 4; HIRA-interacting protein 4; HIRIP 4; OTTHUMP00000164136; PRO3015; RDJ 2; RDJ2; Renal carcinoma antigen NY REN 14; Renal carcinoma antigen NY-REN-14
Cat.#:DNAJA2-2726HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DNAJA2 Protein, GST-tagged
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Cat.#:DNAJA2-12055HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNAJA2, GST-tagged
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Cat.#:DNAJA2-28365THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNAJA2, His-tagged
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Cat.#:DNAJA2-4680MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DNAJA2 Protein
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Cat.#:DNAJA2-1276CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DNAJA2
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Cat.#:DNAJA2-12656ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DNAJA2
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Cat.#:DNAJA2-6894HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DNAJA2 293 Cell Lysate
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Involved Pathway

DNAJA2 involved in several pathways and played different roles in them. We selected most pathways DNAJA2 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNAJA2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
SAR1B; UBE2D1A; SEC24B; NSFL1C; HSPA8; HSPA4L; UBE2D2A; HSP26; UBE2J2; UBE2D4

Protein Function

DNAJA2 has several biochemical functions, for example, ATP binding, chaperone binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNAJA2 itself. We selected most functions DNAJA2 had, and list some proteins which have the same functions with DNAJA2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MAP2K5; PIKFYVE; HSP90AA1.2; TTL; ITPKA; EHD4; TTLL11; VCP; NME2B.1; GM711
Function chaperone binding
Related Protein CP; STIP1; GET4; DNAJB7; DNAJA2; ERP29; SDF2L1; TBCE; CDKN1B; HLA-B
Function glycoprotein binding
Related Protein FLNA; FBXO27; BMPR1A; LRRK2; IGF2R; FOXRED2; Itgam&Itgb2; SERPINA1D; Shh; Serpina1c
Function heat shock protein binding
Related Protein DNAJA2L; LMAN2; NFKBIA; HSPA8; DLST; PACRG; APAF1; PPP5C; BAK1; DNAJC7
Function metal ion binding
Related Protein ATP5S; HBBE2; ZFYVE27; HPDL; ZNF792; ROCK2B; ADAMTS16; LMTK3; ZFP828; KLF11B
Function protein binding
Related Protein TRIM31; ICAM3; FAM131C; B2M; KIF2A; MGST1; RMI1; DRD1; NOP2; VEGFA
Function unfolded protein binding
Related Protein HTRA2; RP2; HSPA5; CCT4; DNAJB1B; SYVN1; DNAJB4; CHAF1A; PPIB; CLGN

Interacting Protein

DNAJA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNAJA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNAJA2.
AICDA; EGFR; P; DNAJA4; NUDC; Tubb4b; SMAD3; Tubb5; SMAD2; TOE1; 15-deoxy-delta(12,14; IRS4; PTBP3