DOC2B Protein, double C2-like domains, beta


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Official Full Name double C2-like domains, beta
Background There are at least two protein isoforms of the Double C2 protein,namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains.DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells.
Synonyms DOC2B; double C2-like domains, beta; DOC2BL, double C2 like domains, beta like; double C2-like domain-containing protein beta; Double C2 like domain containing protein beta; Doc2 beta; Doc2-beta; DOC2B_HUMAN; DOC2BL; Double C2 like domains beta; Double C2 like domains beta like; OTTMUSP00000006522; RP23 78H4.2; double C2-like domains, beta-like
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DOC2B-12115H Recombinant Human DOC2B, GST-tagged E.coli GST
    Human DOC2B-2482H Recombinant Human DOC2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DOC2B-2801H Recombinant Human DOC2B Protein, GST-tagged Wheat Germ GST
    Human DOC2B-502HCL Recombinant Human DOC2B cell lysate N/A
    Mouse DOC2B-4748M Recombinant Mouse DOC2B Protein Mammalian Cell His
    Rat DOC2B-1929R Recombinant Rat DOC2B Protein Mammalian Cell His

    DOC2B involved in several pathways and played different roles in them. We selected most pathways DOC2B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DOC2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    DOC2B has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOC2B itself. We selected most functions DOC2B had, and list some proteins which have the same functions with DOC2B. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PCDH1G22; DNASE1L2; VCAN; LRP2A; APCS; KCNIP1; SYT7; C1R; CIB2; FKBP9
    calcium-dependent phospholipid binding ANXA8; CPNE1; RPH3A; ANXA2A; SYTL2; SYT12; SYT9B; ANXA1B; C2CD4A; SYT2
    clathrin binding HIP1RB; PICALM; SYT12; CCDC167; SYT11B; LDLRAP1; SYTL2; DOC2B; SYT15; SYT17
    syntaxin binding SYT15; SYT7B; TXLNBB; RPH3A; PTPN2; STX8; GOLGA2; VAMP2; SYT2; RPH3AL

    DOC2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOC2B here. Most of them are supplied by our site. Hope this information will be useful for your research of DOC2B.


    Ramalingam, L; Lu, JP; et al. Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet beta-cells. BIOCHEMICAL JOURNAL 464:251-258(2014).
    Li, J; Cantley, J; et al. DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. DIABETOLOGIA 57:2173-2182(2014).

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