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DOC2B

  • Official Full Name

    double C2-like domains, beta

  • Overview

    There are at least two protein isoforms of the Double C2 protein,namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains.DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells.
  • Synonyms

    DOC2B; double C2-like domains, beta; DOC2BL, double C2 like domains, beta like; double C2-like domain-containing protein beta; Double C2 like domain containing protein beta; Doc2 beta; Doc2-beta; DOC2B_HUMAN; DOC2BL; Double C2 like domains beta; Double C2 like domains beta like; OTTMUSP00000006522; RP23 78H4.2; double C2-like domains, beta-like;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOC2B-2801H Recombinant Human DOC2B Protein, GST-tagged Wheat Germ GST
Human DOC2B-12115H Recombinant Human DOC2B, GST-tagged E.coli GST 36-126a.a.
Human DOC2B-502HCL Recombinant Human DOC2B cell lysate N/A
Human DOC2B-1364H Recombinant Human DOC2B Protein, His-tagged E.coli N-His Gly173-Asp412
Human DOC2B-2482H Recombinant Human DOC2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DOC2B-5574H Recombinant Human DOC2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DOC2B-4066HF Recombinant Full Length Human DOC2B Protein, GST-tagged In Vitro Cell Free System GST 412 amino acids
Human DOC2B-2237H Recombinant Human DOC2B Protein (Gly173-Arg397), N-His tagged E.coli N-His Gly173-Arg397
Mouse DOC2B-4748M Recombinant Mouse DOC2B Protein Mammalian Cell His
Mouse Doc2b-2627M Recombinant Mouse Doc2b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DOC2B-2476M Recombinant Mouse DOC2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DOC2B-2476M-B Recombinant Mouse DOC2B Protein Pre-coupled Magnetic Beads HEK293
Rat DOC2B-1929R Recombinant Rat DOC2B Protein Mammalian Cell His
Rat DOC2B-1588R Recombinant Rat DOC2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DOC2B-1588R-B Recombinant Rat DOC2B Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DOC2B Related Articles

DOC2B involved in several pathways and played different roles in them. We selected most pathways DOC2B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DOC2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DOC2B has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOC2B itself. We selected most functions DOC2B had, and list some proteins which have the same functions with DOC2B. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingDLB;CALML3;SLC24A5;MYL1;PLCD3A;EGF;PVALB2;NUCB2;DSG1
calcium-dependent phospholipid bindingSYT9;ANXA13;SYT3;PLA2G4A;SYT11A;ANXA5B;ANXA1C;SYTL3;RPH3A
clathrin bindingSYT17;SYT11;PICALMA;PICALM;DNER;CCDC167;PICALMB;TOM1L1;SYT11B
syntaxin bindingTMED10;STXBP5A;CPLX4;CAV1;STX7;CPLX4A;SYT6;STXBP5L;SYTL3

DOC2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOC2B here. Most of them are supplied by our site. Hope this information will be useful for your research of DOC2B.

Dlg4

Ramalingam, L; Lu, JP; et al. Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet beta-cells. BIOCHEMICAL JOURNAL 464:251-258(2014).
Li, J; Cantley, J; et al. DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. DIABETOLOGIA 57:2173-2182(2014).
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