dok2
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  • Official Full Name
  • docking protein 2, 56kDa
  • Background
  • Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung.
  • Synonyms
  • DOK2; docking protein 2, 56kDa; docking protein 2, 56kD; docking protein 2; Dok 2; p56dok 2; p56(dok-2); downstream of tyrosine kinase 2; p56DOK; p56dok-2
Cat.#:DOK2-2810HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DOK2 Protein, GST-tagged
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Cat.#:DOK2-28083THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DOK2, His-tagged
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Cat.#:DOK2-4761MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DOK2 Protein
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Cat.#:DOK2-6847HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DOK2 293 Cell Lysate
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Involved Pathway

DOK2 involved in several pathways and played different roles in them. We selected most pathways DOK2 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Cell surface interactions at the vascular wall, EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Angiopoietin receptor Tie2-mediated signaling
DOK2; CDKN1A; ELF1; ELF2; AGTR1; CRK; GRB14; GRB7; BMX
Cell surface interactions at the vascular wall
GRB14; SLC3A2A; SLC7A11; CD177; GAS6; SLC7A8A; BSG; SLC7A10; MERTK; CEACAM8
EGFR1 Signaling Pathway
ZNF259; TNK2; PLSCR1; KRT17; USP6NL; PTPN12; GRB14; EPS8; CEBPB; ZFP259
Hemostasis
AKAP1B; MAFGA; KIF3B; GATA1A; STXBP3; SERPINA1L; KIFAP3; SPARC; SERPINF2B; CD9B
IL-4 signaling Pathway
ADRBK2; PAWR; SPI1B; DOK2; HMGA1-RS1; IL4R.1
IL2-mediated signaling events
DOK2; CISH; IKZF3; STAM2
IL4-mediated signaling events
MYBL1; NIPAL1; RETNLB; CCL26; IgG3; DOK2; IRF4; EGR2; TFF3; MYB
Tie2 Signaling
DOK2; GRB14; ANGPT2A

Protein Function

DOK2 has several biochemical functions, for example, insulin receptor binding, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK2 itself. We selected most functions DOK2 had, and list some proteins which have the same functions with DOK2. You can find most of the proteins on our site.
Function
Related Protein
Function insulin receptor binding
Related Protein SLC2A2; FRS2B; INS2; IGF1; DOK6; PDPK1; PIK3R1; ENPP1; DOK3; INS1
Function protein binding
Related Protein SLC6A20; CRLF1; ESYT2; VPS37B; CTSG; PNRC2; MPP2; MATR3; ASCC1; FHOD1
Function receptor signaling protein activity
Related Protein CD19; RAF1A; DOK2; FLRT2; FLRT1; PDCL; ARF1; NCR1; IL4R; RGS14A
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein GAB2; IRS1; STAP1; FRS2; SH2B2; DOK2; PIK3R1; BLNK; SHC1; TRAT1

Interacting Protein

DOK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK2.
POT1; LCK; STAT3; CRK; CRK; CRKL; DOK3; APPL1; CFLAR; SPOP; SSSCA1