Recombinant Human DOK2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: DOK2-1233H
• Product Overview: DOK2 MS Standard C13 and N15-labeled recombinant protein (NP_003965) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 45.4 kDa
• AA Sequence: MGDGAVKQGFLYLQQQQTFGKKWRR FGASLYGGSDCALARLELQEGPEKP RRCEAARKVIRLSDCLRVAEAGGEA SSPRDTSAFFLETKERLYLLAAPAA ERGDWVQAICLLAFPGQRKELSGPE GKQSRPCMEENELYSSAVTVGPHKE FAVTMRPTEASERCHLRGSYTLRAG ESALELWGGPEPGTQLYDWPYRFLR RFGRDKVTFSFEAGRRCVSGEGNFE FETRQGNEIFLALEEAISAQKNAAP ATPQPQPATIPASLPRPDSPYSRPH DSLPPPSPTTPVPAPRPRGQEGEYA VPFDAVARSLGKNFRGILAVPPQLL ADPLYDSIEETLPPRPDHIYDEPEG VAALSLYDSPQEPRGEAWRRQATAD RDPAGLQHVQPAGQDFSASGWQPGT EYDNVVLKKGPKTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: DOK2 docking protein 2 [ Homo sapiens (human) ]
• Official Symbol: DOK2
• Synonyms: DOK2; docking protein 2, 56kDa; docking protein 2, 56kD; docking protein 2; Dok 2; p56dok 2; p56(dok-2); downstream of tyrosine kinase 2; p56DOK; p56dok-2
• Gene ID: 9046
• mRNA Refseq: NM_003974
• Protein Refseq: NP_003965
• MIM: 604997
• UniProt ID: O60496