dsg1
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  • Official Full Name
  • Desmoglein 1
  • Background
  • Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
  • Synonyms
  • DSG1; desmoglein 1; DGI; CDHF4; PPKS1; Cadherin family member 4; SPPK1; Desmosomal glycoprotein 1; DSG; Pemphigus foliaceus antigen; desmoglein-1; DG1; OTTHUMP00000162826; DSG2; desmoglein 2; HDGC; CDHF5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037; Desmoglein-2
Cat.#:DSG1-2890HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DSG1 Protein, GST-tagged
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Cat.#:DSG1-12178HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSG1, His-tagged
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Cat.#:DSG1-1601HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Desmoglein 1
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Cat.#:DSG1-26581THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DSG1
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Cat.#:DSG1-820HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSG1 protein, His & GST-tagged
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Cat.#:DSG1-8319HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human DSG1
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Cat.#:DSG1-512HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DSG1 cell lysate
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Involved Pathway

DSG1 involved in several pathways and played different roles in them. We selected most pathways DSG1 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
DCC; NFKB1; RNF8; IRF2A; NGF; DAPK1; CYCS; GZME; IRAK2; AKT2
Apoptotic cleavage of cell adhesion proteins
DSP; DSG3; PKP1; PTBP3; CTNNB2; DSG2; DSG1; CTNNB1; OCLN
Apoptotic cleavage of cellular proteins
DSG2; DSG3; SATB1; BCAP31; DBNLA; STK24; DBNL; PKP1; GAS2; VIML
Apoptotic execution phase
SATB1; GAS2; STK24B; DNM1L; DSG3; DSG2; HIST1H1C; CASP6L2; PLEC; PKP1
Programmed Cell Death
GZMC; DSG3; STK24A; PKP1; PLECA; DIABLOA; RIPK3; DSP; SATB1; MLKL
Staphylococcus aureus infection
FCGR3B; ITGB2L; C3; FCAR; HLA-DQA1; MBL1; ITGB2; C1QB; H2-AB1; FCGR1A

Protein Function

DSG1 has several biochemical functions, for example, calcium ion binding, gamma-catenin binding, toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG1 itself. We selected most functions DSG1 had, and list some proteins which have the same functions with DSG1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein LTBP3; PLSCR3; CGREF1; PCDHA5; MAN1C1; THBS4A; SERPINB1A; PPP3CB; CAPN3; CDH1
Function gamma-catenin binding
Related Protein FER; LEF1; DSG1A; PTBP3; TCF7L2; CDH2; APC2; CTNNA1; PTPRJ; PTPRK
Function toxic substance binding
Related Protein GUCY2C; PHAX; EPHX2; A4GALT; DSG1; NEFH; CHRNA7; AZU1; ASS1; Alb

Interacting Protein

DSG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG1.
SSSCA1; USP1; GH1; OTUD4; USP53; VRK3; q9nz47_human; RUVBL1; midostaurin; cona_canen; ESR1; CFTR; IQGAP1; PLK1; CD81; GABARAPL2; PPP2R2B; MAPK7; IQCB1

DSG1 Related Articles

Aoki, V; Rivitti, EA; et al. Update on fogo selvagem, an endemic form of pemphigus foliaceus. JOURNAL OF DERMATOLOGY 42:18-26(2015).
Kinjyo, C; Kaneko, T; et al. Oral lichen planus with antibodies to desmogleins 1 and 3. JOURNAL OF DERMATOLOGY 42:40-41(2015).