Active Recombinant Human DSG1 Protein, Fc tagged
| Cat.No. : | DSG1-1601H |
| Product Overview : | Active Recombinant Human DSG1 Protein (Glu50-His545) with Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line. |
| Availability | May 22, 2026 |
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| Species : | Human |
| Source : | Mouse myeloma cell line |
| Tag : | Fc |
| Protein Length : | 50-545 aa |
| Description : | This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. |
| Form : | Disulfide-linked homodimer, Lyophilized from a 0.2 μm filtered solution in Tris, NaCl and Citrate. |
| Molecular Mass : | 82 kDa (monomer) |
| Endotoxin : | < 1.0 EU/μg of the protein by the LAL method. |
| Purity : | > 95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Applications : | Bioactivity |
| Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
| Shipping : | The product is shipped at ambient temperature. |
| Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
| Reference : | 1. Nollet, R. et al. (2000) J. Mol. Biol. 299:551. 2. Elias, P. et al. (2001) J. Cell Biol. 153:243. |
| N-terminal Sequence Analysis : | Glu50 |
| Gene Name | DSG1 desmoglein 1 [ Homo sapiens (human) ] |
| Official Symbol | DSG1 |
| Synonyms | DSG1; desmoglein 1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA; desmoglein-1; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen |
| Gene ID | 1828 |
| mRNA Refseq | NM_001942 |
| Protein Refseq | NP_001933 |
| MIM | 125670 |
| UniProt ID | Q02413 |
Not For Human Consumption!
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