dusp1
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  • Official Full Name
  • dual specificity phosphatase 1
  • Background
  • The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
  • Synonyms
  • DUSP1; dual specificity phosphatase 1; PTPN10; dual specificity protein phosphatase 1; CL100; HVH1; MKP 1; MAP kinase phosphatase 1; protein-tyrosine phosphatase CL100; dual specificity protein phosphatase hVH1; serine/threonine specific protein phosphata
Cat.#:DUSP1-852HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP1, His-tagged
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Cat.#:DUSP1-28071THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DUSP1
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Cat.#:DUSP1-32HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DUSP1 protein, GST-tagged
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Cat.#:DUSP1-4874MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DUSP1 Protein
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Cat.#:DUSP1-1347RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DUSP1 Protein, His-tagged
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Cat.#:DUSP1-3684CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DUSP1
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Cat.#:DUSP1-12297ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DUSP1
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Involved Pathway

DUSP1 involved in several pathways and played different roles in them. We selected most pathways DUSP1 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
CSK; PSME3; CSF2; RASGRP1; CSF2RB; SPTB; JAK2; PEA15A; PAQR3A; PAQR3B
ATF-2 transcription factor network
JUN; POU2F1; MAPK14; KCNA3; ATF2; JDP2; DUSP1; DUSP5; CREB1; CDK4
Axon guidance
RASGRP1; EFNB3; SEMA4A; JAK2; ST8SIA2; CFL2; EFNA3; CSF2RA; FES; CXCL12
Cytokine Signaling in Immune system
SPTA1; RASGRP1; GBP6; TRIM8; SPNA1; FCGR1B; HBEGF; IFI30; RASGEF1A; FRS2A
DAP12 interactions
FGF18B; PAQR3B; MARK3; FGF20A; IL17RD; PEA15A; LAMTOR2; FRS2; HBEGF; GRAP2A
DAP12 signaling
PRKAR1AA; PEA15A; PEA15; NRG2A; TRAT1; HBEGF; DUSP6; FRS3; SPTBN2; PAQR3A
Developmental Biology
PHB; COL6A2; KIF4; CLTB; CDK8; SHB; CACNG2; SMAD3B; PEA15; GPC1B
Direct p53 effectors
DDB2; CTSD; PCBP4; HIC1; DGCR8; GDF15; ZNF385A; EPHA2; FOXA1; PPM1J

Protein Function

DUSP1 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP1 itself. We selected most functions DUSP1 had, and list some proteins which have the same functions with DUSP1. You can find most of the proteins on our site.
Function
Related Protein
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein DUSP2; DUSP14; SACM1L; PXYLP1; DUSP5; TENC1; DUSP18; PTPRQ; DUSP4; DUSP8A
Function non-membrane spanning protein tyrosine phosphatase activity
Related Protein PTPN18; PTPN9; PTPN4; ACP1; PTPN12; DUSP1; PTPN11
Function protein binding
Related Protein TOE1; ATP6V0D2; IFNA4; APITD1; NDUFB9; NSUN4; GMPPB; DES; SEPT2; ITGB5
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein EPM2A; LRP8; DUSP2; DUSP22; PTP4A2B; CDKN3; RNGTT; DUSP13A; PTPMT1; DUSP3
Function protein tyrosine/threonine phosphatase activity
Related Protein CTDSPL2A; DUSP19; SGPP2; NT5DC3; CTDSPL2B; SACM1L; PTPRQ; PXYLP1; DUSP2; DUSP4

Interacting Protein

DUSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP1.
MAPK3; MAPK14; MAPK1; SKP2; UBB

DUSP1 Related Articles

Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).
Ying, HJ; Kang, YH; et al. MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway. JOURNAL OF IMMUNOLOGY 194:1239-1251(2015).