|Official Full Name||dual specificity phosphatase 1|
|Background||The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.|
|Synonyms||DUSP1; dual specificity phosphatase 1; PTPN10; dual specificity protein phosphatase 1; CL100; HVH1; MKP 1; MAP kinase phosphatase 1; protein-tyrosine phosphatase CL100; dual specificity protein phosphatase hVH1; serine/threonine specific protein phosphata|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
DUSP1 involved in several pathways and played different roles in them. We selected most pathways DUSP1 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ARMS-mediated activation||LAMTOR2; DUSP7; PEA15A; PSMD10; CNKSR1; CSF2RB; SPTBN1; NRG4; HBEGF; CRK|
|ATF-2 transcription factor network||DUSP5; POU2F1; JDP2; MAPK14; CDK4; RUVBL2; CSRP2; DDIT3; HRK; KCNA3|
|Axon guidance||FGF20A; CDK5R1B; EPHA2A; CHL1; EPHA5; SEMA6A; EPHA4; SEMA3G; CRMP1; DUSP4|
|Cytokine Signaling in Immune system||PELI1; FGF8B; IFITM2; UBE2V1; FRS2A; TRIM8; FRS3; TRIM45; HAVCR2; OSTN|
|DAP12 interactions||DUSP6; CD300LB; FRS3; PAQR3B; FGF8B; MARK3; NRG4; DUSP7; SIGLEC14; RASGRP4|
|DAP12 signaling||PEBP1; CSF2RB; FRS2; WDR83; DUSP4; CNKSR1; KBTBD7; FGF20A; DUSP5; PTPRA|
|Developmental Biology||GFRA1; SMAD3B; PEBP1; MYOG; DUSP1; PITPNA; NRG4; RGMB; MED18; ANK2B|
|Direct p53 effectors||GDF15; PPM1J; TRIAP1; FOXA1; HIC1; DDX5; DGCR8; PLK3; ZNF385A; AIFM2|
DUSP1 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP1 itself. We selected most functions DUSP1 had, and list some proteins which have the same functions with DUSP1. You can find most of the proteins on our site.
|MAP kinase tyrosine/serine/threonine phosphatase activity||DUSP6; DUSP21; DUSP2; NT5DC3; DUSP14; DUSP8A; DUSP7; DUSP16; DUSP5; CTDSPL2B|
|non-membrane spanning protein tyrosine phosphatase activity||PTPN4; PTPN12; PTPN9; PTPN18; DUSP1; PTPN11; ACP1|
|protein binding||ZNF514; ZNF385C; CALR; RAB11A; KDR; FBXL19; FHOD1; EFS; EFNB2; REEP5|
|protein tyrosine/serine/threonine phosphatase activity||PTPDC1; SACM1LA; DUSP3; DUSP21; DUSP13; PXYLP1; SGPP2; CDC14B; SACM1LB; DUSP8A|
|protein tyrosine/threonine phosphatase activity||CTDSPL2A; SACM1LA; CTDSPL2B; SGPP2; TENC1; DUSP2; DUSP4; SACM1L; SACM1LB; PTPRQ|
DUSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP1.
MAPK3; MAPK14; MAPK1; SKP2; UBB