DUSP1 Protein, dual specificity phosphatase 1

DUSP1

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DUSP1

Official Full Name dual specificity phosphatase 1
Background The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes.Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Synonyms DUSP1; dual specificity phosphatase 1; PTPN10; dual specificity protein phosphatase 1; CL100; HVH1; MKP 1; MAP kinase phosphatase 1; protein-tyrosine phosphatase CL100; dual specificity protein phosphatase hVH1; serine/threonine specific protein phosphata
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP1-28071TH Recombinant Human DUSP1 Wheat Germ N/A
    Human DUSP1-32H Recombinant Human DUSP1 protein, GST-tagged Wheat Germ GST
    Human DUSP1-852H Recombinant Human DUSP1, His-tagged E.coli His
    Mouse DUSP1-4874M Recombinant Mouse DUSP1 Protein Mammalian Cell His
    Rhesus Macaque DUSP1-1347R Recombinant Rhesus monkey DUSP1 Protein, His-tagged Mammalian Cell His
    Chicken DUSP1-3684C Recombinant Chicken DUSP1 Mammalian Cell His
    Zebrafish DUSP1-12297Z Recombinant Zebrafish DUSP1 Mammalian Cell His

    DUSP1 involved in several pathways and played different roles in them. We selected most pathways DUSP1 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation LAMTOR2; DUSP7; PEA15A; PSMD10; CNKSR1; CSF2RB; SPTBN1; NRG4; HBEGF; CRK
    ATF-2 transcription factor network DUSP5; POU2F1; JDP2; MAPK14; CDK4; RUVBL2; CSRP2; DDIT3; HRK; KCNA3
    Axon guidance FGF20A; CDK5R1B; EPHA2A; CHL1; EPHA5; SEMA6A; EPHA4; SEMA3G; CRMP1; DUSP4
    Cytokine Signaling in Immune system PELI1; FGF8B; IFITM2; UBE2V1; FRS2A; TRIM8; FRS3; TRIM45; HAVCR2; OSTN
    DAP12 interactions DUSP6; CD300LB; FRS3; PAQR3B; FGF8B; MARK3; NRG4; DUSP7; SIGLEC14; RASGRP4
    DAP12 signaling PEBP1; CSF2RB; FRS2; WDR83; DUSP4; CNKSR1; KBTBD7; FGF20A; DUSP5; PTPRA
    Developmental Biology GFRA1; SMAD3B; PEBP1; MYOG; DUSP1; PITPNA; NRG4; RGMB; MED18; ANK2B
    Direct p53 effectors GDF15; PPM1J; TRIAP1; FOXA1; HIC1; DDX5; DGCR8; PLK3; ZNF385A; AIFM2

    DUSP1 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP1 itself. We selected most functions DUSP1 had, and list some proteins which have the same functions with DUSP1. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase tyrosine/serine/threonine phosphatase activity DUSP6; DUSP21; DUSP2; NT5DC3; DUSP14; DUSP8A; DUSP7; DUSP16; DUSP5; CTDSPL2B
    non-membrane spanning protein tyrosine phosphatase activity PTPN4; PTPN12; PTPN9; PTPN18; DUSP1; PTPN11; ACP1
    protein binding ZNF514; ZNF385C; CALR; RAB11A; KDR; FBXL19; FHOD1; EFS; EFNB2; REEP5
    protein tyrosine/serine/threonine phosphatase activity PTPDC1; SACM1LA; DUSP3; DUSP21; DUSP13; PXYLP1; SGPP2; CDC14B; SACM1LB; DUSP8A
    protein tyrosine/threonine phosphatase activity CTDSPL2A; SACM1LA; CTDSPL2B; SGPP2; TENC1; DUSP2; DUSP4; SACM1L; SACM1LB; PTPRQ

    DUSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP1.

    MAPK3; MAPK14; MAPK1; SKP2; UBB

    Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).
    Ying, HJ; Kang, YH; et al. MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway. JOURNAL OF IMMUNOLOGY 194:1239-1251(2015).

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