dusp5
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  • Official Full Name
  • dual specificity phosphatase 5
  • Background
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.
  • Synonyms
  • DUSP5; dual specificity phosphatase 5; dual specificity protein phosphatase 5; HVH3; VH1-like phosphatase 3; dual specificity protein phosphatase hVH3; serine/threonine specific protein phosphatase; DUSP
Cat.#:DUSP5-2943HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DUSP5 Protein, GST-tagged
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Cat.#:DUSP5-382HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP5 Protein, His-tagged
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Cat.#:Dusp5-383MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dusp5 Protein, His-tagged
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Cat.#:DUSP5-28378THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DUSP5
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Cat.#:DUSP5-330HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DUSP5 Protein, His-tagged
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Cat.#:DUSP5-1977RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DUSP5 Protein
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Cat.#:DUSP5-11845ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DUSP5
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Cat.#:DUSP5-6772HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DUSP5 293 Cell Lysate
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Involved Pathway

DUSP5 involved in several pathways and played different roles in them. We selected most pathways DUSP5 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
DLG4; NRG4; DUSP4; CSF2RB; PSMD9; SPRED1; WDR83; SPTA1; SPNA2; DUSP6
ATF-2 transcription factor network
JDP2; GADD45A; DUSP1; HRK; MAPK14; DDIT3; POU2F1; JUN; DUSP5; CREB1
Axon guidance
AGRN; GFRA2; SEMA3C; Sema3f; ABL1; CSF2; DUSP2; DUSP7; CSNK2A1; PTK2
Cytokine Signaling in Immune system
DAB2IPB; IFIT12; NUPL2; BST2; WDR83; DUSP9; SPRED1; IFI6; GBP2; PAQR3B
DAP12 interactions
FGF20A; AGO1; PEBP1; SIRPB1; SPTBN1; PEA15; FRS2B; PAQR3B; CNKSR1; NEFLB
DAP12 signaling
KBTBD7; AGO1; NEFLB; SPTB; FRS2; FGF8B; SPTBN2; CSF2RB; PTPRA; GRAP2A
Developmental Biology
GFRA4; NADL1.1; KDR; TCF4; JAK1; LEFTY1; EFNB2A; CACNG2; INSM1A; EPHB4B
Direct p53 effectors
DGCR8; DUSP1; FOXA1; CTSD; PRDM1; BCL2L14; SCN3B; DDX5; BNIP3L; NDRG1

Protein Function

DUSP5 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP5 itself. We selected most functions DUSP5 had, and list some proteins which have the same functions with DUSP5. You can find most of the proteins on our site.
Function
Related Protein
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein DUSP5; CTDSPL2A; DUSP2; DUSP8A; DUSP18; DUSP6; DUSP21; PTPRQ; SACM1LB; DUSP9
Function protein binding
Related Protein S100P; ROR2; UCKL1; TEK; NANOS3; MRPS16; MALSU1; NXF1; CHAC1; CCS
Function protein tyrosine phosphatase activity
Related Protein MDP1; DUSP22A; EVLA; PTENB; PTPRU; PTP4A2A; PTPRO; PTEN; MTMR7A; DUSP14
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein DUSP3B; PXYLP1; SACM1L; PTPRQ; DUSP1; PTP4A2A; PTP4A1; DUSP12; DUSP19A; RNGTT

Interacting Protein

DUSP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP5.
DUSP5

DUSP5 Related Articles

Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).
Moon, SJ; Lim, MA; et al. Dual-Specificity Phosphatase 5 Attenuates Autoimmune Arthritis in Mice via Reciprocal Regulation of the Th17/Treg Cell Balance and Inhibition of Osteoclastogenesis. ARTHRITIS & RHEUMATOLOGY 66:3083-3095(2014).