DYRK3 Protein, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3


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Official Full Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Background This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms DYRK3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual specificity tyrosine-phosphorylation-regulated kinase 3; dual specificity tyrosine (Y) phosphorylation regulated kinase 5; hYAK3 2; protein kinase Dyrk3; RED; REDK; regulatory e
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rat
    • Source :
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DYRK3-2989H Recombinant Human DYRK3 Protein, GST-tagged Insect Cell GST
    Human DYRK3-2990H Recombinant Human DYRK3 Protein, GST-tagged Wheat Germ GST
    Human DYRK3-623HCL Recombinant Human DYRK3 cell lysate Insect Cell N/A
    Human DYRK3-972H Recombinant Human DYRK3, His & GST tagged Insect Cell His/GST
    Rat DYRK3-1991R Recombinant Rat DYRK3 Protein Mammalian Cell His
    Cynomolgus Monkey DYRK3-474C Recombinant Cynomolgus DYRK3 Protein, His-tagged Mammalian Cell His

    DYRK3 involved in several pathways and played different roles in them. We selected most pathways DYRK3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    DYRK3 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK3 itself. We selected most functions DYRK3 had, and list some proteins which have the same functions with DYRK3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PIK3C2A; ABCB5; RAD17; SMC6; ATP6V1B1; ERCC6L2; DICER1; DDX39; CSNK1A1L; TTLL2
    magnesium ion binding TSSK3; ATP8B3; FDXACB1; PRTFDC1; NCS1; OPA1; GLUL; PAPOLA; NUDT7; ARF1
    protein kinase activity CASKB; ERBB3B; SGK3; SGK2B; CDK11B; PRKACBB; NLK1; IRAK1; BRAF; RIPK3
    protein serine/threonine kinase activity RPS6KAL; DCLK1; HIPK2; CSNK1DB; OXSR1B; MAP3K12; PLK4; PLK2B; IKBKB; RPS6KA3B
    protein serine/threonine/tyrosine kinase activity CLK3; DYRK2; AURKC; DYRK1AA; ACVR2B; TESK1; DYRK3; SGK1; RPS6KA2; PRKAA2
    protein tyrosine kinase activity SHC1; ERBB4; EGFR; ABL1; MAP2K4; KITA; JAK2; EPHA7; TNK2B; IGF1RB

    DYRK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK3.

    saicar; PRNP; PKM; SORL1; SIRT1

    Souchet, B; Latour, A; et al. Molecular Rescue of DYRK1A Overexpression in Cystathionine Beta Synthase-Deficient Mouse Brain by Enriched Environment Combined with Voluntary Exercise. JOURNAL OF MOLECULAR NEUROSCIENCE 55:318-323(2015).
    Mennenga, SE; Gerson, JE; et al. Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing. PHYSIOLOGY & BEHAVIOR 138:260-265(2015).

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