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E2F3

Official Full Name

E2F transcription factor 3
Overview

This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Synonyms

E2F3; E2F transcription factor 3; E2F-3; transcription factor E2F3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	E2F3-118H	Recombinant Human E2F3 Protein, His-tagged	E.coli	His		Inquiry
Human	E2F3-27375TH	Recombinant Human E2F3	Wheat Germ	N/A	133 amino acids	Inquiry
Human	E2F3-3006H	Recombinant Human E2F3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	E2F3-12247H	Recombinant Human E2F3, His-tagged	E.coli	His	1-110a.a.	$319 / 25ug
Human	E2F3-6742HCL	Recombinant Human E2F3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	E2F3-134HF	Recombinant Full Length Human E2F3 Protein	In Vitro Cell Free System		133 amino acids	Inquiry
Human	E2F3-4112HF	Recombinant Full Length Human E2F3 Protein, GST-tagged	In Vitro Cell Free System	GST	133 amino acids	Inquiry
Mouse	E2F3-4932M	Recombinant Mouse E2F3 Protein	Mammalian Cell	His		Inquiry
Mouse	E2F3-2596M	Recombinant Mouse E2F3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	E2F3-2596M-B	Recombinant Mouse E2F3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	E2F3-5118Z	Recombinant Zebrafish E2F3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

E2F3 involved in several pathways and played different roles in them. We selected most pathways E2F3 participated on our site, such as Assembly of the pre-replicative complex, Association of licensing factors with the pre-replicative complex, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the pre-replicative complex	E2F3;MCM8;E2F1;GMNN;CDT1;E2F2
Association of licensing factors with the pre-replicative complex	E2F2;E2F3;E2F1;GMNN;CDT1
Bladder cancer	CDKN2A;HRAS;DAPK2;KRAS;TYMP;MMP2;ERBB2;MAP2K1;RAF1
CDC6 association with the ORC:origin complex	E2F3;E2F2;MCM8
Cell Cycle	HDAC1;MYC;ANAPC4;RAD17;CLASP1;ORC6;CCNE2;SPC25;ORC1
Cell Cycle, Mitotic	PCM1;MLF1IP;PDS5A;CP110;CEP63;CENPA;SPC25;NUPL2;B9D2
Cellular Senescence	ACD;CBX8B;CBX4;HTATIP;SUZ12;MOV10;CDKN2B;AGO1;UBN1

E2F3 has several biochemical functions, for example, core promoter binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F3 itself. We selected most functions E2F3 had, and list some proteins which have the same functions with E2F3. You can find most of the proteins on our site.

Function	Related Protein
core promoter binding	SAFB;SFPQ;XBP1;CCAR1;EZH2;SPI1;CRY1;GATA1;HNRNPU
protein binding	MSLN;IGSF1;PPP2R2B;RNF182;RBM17;SIK3;C7orf31;GMCL1;SEC16B
transcription factor activity, sequence-specific DNA binding	HOXC4;FOXP3A;HCFC1;KDM5A;SCML2;HNF1BA;TCF7L1B;IKZF4;POU2F2

E2F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F3.

RB1; MSH2; HELLS; Sp1; E7; E7; MYBL2; MYO1C; SCD; TCERG1; SLC16A3; MYO1B; AKAP8