e2f3
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  • Official Full Name
  • E2F transcription factor 3
  • Background
  • This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
  • Synonyms
  • E2F3; E2F transcription factor 3; E2F-3; transcription factor E2F3;
Cat.#:E2F3-3006HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human E2F3 Protein, GST-tagged
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Cat.#:E2F3-118HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E2F3 Protein, His-tagged
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Cat.#:E2F3-12247HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E2F3, His-tagged
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Cat.#:E2F3-27375THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human E2F3
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Cat.#:E2F3-4932MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse E2F3 Protein
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Cat.#:E2F3-5118ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish E2F3
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Cat.#:E2F3-6742HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human E2F3 293 Cell Lysate
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Involved Pathway

E2F3 involved in several pathways and played different roles in them. We selected most pathways E2F3 participated on our site, such as Assembly of the pre-replicative complex, Association of licensing factors with the pre-replicative complex, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the pre-replicative complex
E2F1; MCM8; E2F3; CDT1; E2F2; GMNN
Association of licensing factors with the pre-replicative complex
CDT1; E2F3; GMNN; E2F2; E2F1
Bladder cancer
MMP9; KRAS; E2F2; CDKN2A; ERBB2; DAPK2; MAPK3; TRP53; CCND1; FGFR3
CDC6 association with the ORC:origin complex
MCM8; E2F3; E2F2
Cell Cycle
NDE1; KIF18A; AURKB; ORC4L; TUBGCP5; NEK7; HDAC1; NEK6; ORC6; USO1
Cell Cycle, Mitotic
DYRK1A; ARPP19B; POLD3; ODF2; STAG1; PANE1; CLASP1A; CENPC1; NIPBLA; CENPH
Cellular Senescence
HIST1H1D; HIST1H1E; ERF; SUZ12B; H3F3D; EED; RING1; HIST1H1A; E2F3; POT1

Protein Function

E2F3 has several biochemical functions, for example, core promoter binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F3 itself. We selected most functions E2F3 had, and list some proteins which have the same functions with E2F3. You can find most of the proteins on our site.
Function
Related Protein
Function core promoter binding
Related Protein PYDC3; HMGA2; RB1; MYOD1; HDAC1; IRF9; REST; MYBBP1A; ELK4; MTF1
Function protein binding
Related Protein PTPRR; DUSP1; SRF; LDHB; CD274; WTIP; ADAMTS4; LRFN2; VSTM2L; FBXL5
Function transcription factor activity, sequence-specific DNA binding
Related Protein MYF6; CREBL2; HMG20A; TEAD2; MECOM; HOXC8A; ZNF483; ZBTB48; POU2F1B; POU4F1

Interacting Protein

E2F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F3.
RB1; MSH2; HELLS; Sp1; E7; E7; MYBL2; MYO1C; SCD; TCERG1; SLC16A3; MYO1B; AKAP8