e2f6
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  • Official Full Name
  • E2F transcription factor 6
  • Background
  • This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.
  • Synonyms
  • E2F6; E2F transcription factor 6; transcription factor E2F6; E2F 6; E2F transcription factor 6, isoform 1; E2F-6; MGC111545
Cat.#:E2F6-12249HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E2F6, GST-tagged
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Cat.#:E2F6-26508THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human E2F6
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Cat.#:E2F6-4935MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse E2F6 Protein
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Cat.#:E2F6-475CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus E2F6 Protein, His-tagged
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Cat.#:E2F6-1368RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey E2F6 Protein, His-tagged
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Cat.#:E2F6-4519CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken E2F6
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Cat.#:E2F6-521HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human E2F6 cell lysate
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Involved Pathway

E2F6 involved in several pathways and played different roles in them. We selected most pathways E2F6 participated on our site, such as Cell cycle, E2F transcription factor network, G1 to S cell cycle control, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
MAD2L2; CDK11B; SMAD3A; CDK6; KIF2C; TCTN2; CENPP; CETN2; ORC1; SGOL2
E2F transcription factor network
YY1; CEBPA; CDKN2C; SMARCA2; CES3; TRIM28; CES1; HBP1; PRMT5; DHFR
G1 to S cell cycle control
CDKN1C; TFDP1B; MYT1; ATF6B; E2F6

Protein Function

E2F6 has several biochemical functions, for example, DNA binding, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F6 itself. We selected most functions E2F6 had, and list some proteins which have the same functions with E2F6. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein SOX21; NR2F6B; GTF2IRD1; ZNF221; POLR2J2; PBX1; HOXB1A; RPS15; SNAPC1; ZNF143
Function protein binding
Related Protein RAB7L1; NOMO2; APIP; RFPL3; TOP2A; TF; ZNF496; GBP5; SNAP25; GREM1
Function transcription corepressor activity
Related Protein BASP1; KCNIP3; SMARCA4; RARA; LHX1; LDB1; HOXC6; NEUROD2; NR2F2; MYBBP1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein EOMESB; HOXA3A; SIM1; GATAD1; DMRT1; ZHX2; PGBD1; KLF9; ZNF131; PCGF6

Interacting Protein

E2F6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F6 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F6.
TFDP2; TFDP1; KRTAP10-7; PIK3R3; Ring1; BMI1