egr2
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  • Official Full Name
  • early growth response 2
  • Background
  • The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
  • Synonyms
  • EGR2; early growth response 2; AT591; CMT1D; CMT4E; KROX20; E3 SUMO-protein ligase EGR2; zinc finger protein Krox-20; early growth response protein 2; KROX-20, Drosophila, homolog (early growth response-2);
Cat.#:EGR2-3123HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EGR2 Protein, GST-tagged
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Cat.#:EGR2-12329HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGR2, GST-tagged
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Cat.#:EGR2-28469THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human EGR2
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Cat.#:EGR2-6976HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGR2 protein, His & T7-tagged
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Cat.#:EGR2-777HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGR2 Protein, His-tagged
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Cat.#:Egr2-30MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Egr2 protein, His-tagged
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Cat.#:EGR2-5053MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EGR2 Protein
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Cat.#:EGR2-2033RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EGR2 Protein
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Cat.#:EGR2-1400RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EGR2 Protein, His-tagged
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Cat.#:EGR2-6691HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EGR2 293 Cell Lysate
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Involved Pathway

EGR2 involved in several pathways and played different roles in them. We selected most pathways EGR2 participated on our site, such as Adipogenesis, BDNF signaling pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adipogenesis
RORAA; E2F4; MEF2B; NR2F1; NAMPT; DLK1; KLF5; EGR2B; AGPAT2; GTF3AA
BDNF signaling pathway
CSNK2A1P; CDKL5; EIF4E; CNR1; KCNN2; CDK5; GRIP1; IGF2BP1; SIRPA; FRS3
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IRF4; EGR2; JUNB; EGR3; EGR1; IKZF1; BATF3; CSF2; EGR4; DGKA
Developmental Biology
TCF3A; LGI1A; ARPC1B; EFNB2A; DNM1; SPRED3; SMAD3B; NRG3; DOCK1; EPHA2A
HTLV-I infection
SMAD3; CD40; PIK3R3; CDC16; CDC20; DLG1; SLC25A31; WNT5A; CCND1; CDC26
Hepatitis B
TGFB3; MAP2K4; CREB5; IFNA21; STAT4; DDB2; IFIH1; MAP2K2; MAPK8; CCNE2
IL4-mediated signaling events
MYB; TFF3; DOK2; EGR2; NIPAL1; RETNLB; PARP14; IgG3; IRF4; CCL26
Transcriptional regulation of white adipocyte differentiation
MED29; CDK19; MED21; EBF1; NR2F2; EGR2; MED9; MED22; MED19; MED18

Protein Function

EGR2 has several biochemical functions, for example, HMG box domain binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR2 itself. We selected most functions EGR2 had, and list some proteins which have the same functions with EGR2. You can find most of the proteins on our site.
Function
Related Protein
Function HMG box domain binding
Related Protein DLX5; GATA3; PRRX1; UTF1; HOXA3; OLIG2; ALX4; PAX3; HHEX; EGR2
Function RNA polymerase II activating transcription factor binding
Related Protein SMAD3; BEX1; HIPK2; ISL1; ZFPM1; NHLH2; EP300; PITX2; CREB1; NEUROD1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein IFI16; KLF13; ZKSCAN3; PPARA; ZGPAT; FUBP3; SKIL; HOXD13; SREBF1; ELF3
Function chromatin binding
Related Protein TOX2; HIF1AB; NUPR1; TADA2B; RFX4; ING5; TBL1Y; PRKCBP1L; PRMT6; MBD5
Function ligase activity
Related Protein RNF25; BIRC3; RANBP2; SIAH2L; RNF216; HERC3; ITCH; MIB2; MUL1; RNF181
Function metal ion binding
Related Protein BCL11BA; FEZF1; CMTM2A; PPP2CA; ZFP526; ZFP521; OAS3; KLK4; ZBTB9; AMPD2
Function protein binding
Related Protein BIRC3; SIL1; CTNNB1; SPINK2; PBXIP1; LDB1; SMC6; BLMH; C21orf7; CD226
Function transcription factor activity, sequence-specific DNA binding
Related Protein DRAP1; ATF7A; ZNF189; ZNF480; XBP1; ETS2; BRD8; TFE3; YBX1; HIRA
Function transcription regulatory region DNA binding
Related Protein BCOR; ATF5; SOX2; TCF7L1B; ZNF217; KLF2A; RFX6; Arid4b; HNF4A; SMAD4
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CEBPE; SMAD4; MYOCD; SOX1; FOXC2; NCOA3; NKX2-8; TXK; ETV6; SREBF1
Function ubiquitin protein ligase binding
Related Protein TRAF4; RPA3; PRDX6; SPOP; MAP1LC3C; UBE2H; C10orf46; NPLOC4; MAGEC2; PRKAR1A

Interacting Protein

EGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR2.
NDUFS2; BPGM; ACP5; HCFC1; RPL7L1; RBM15B; HN1L; RIMKLB; MED31; Nab2

EGR2 Related Articles

Okamura, T; Sumitomo, S; et al. TGF-beta 3-expressing CD4(+)CD25(-)LAG3(+) regulatory T cells control humoral immune responses. NATURE COMMUNICATIONS 6:-(2015).
Pletinckx, K; Vaeth, M; et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-)IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. EUROPEAN JOURNAL OF IMMUNOLOGY 45:480-491(2015).