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EGR2

  • Official Full Name

    early growth response 2

  • Overview

    The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
  • Synonyms

    EGR2; early growth response 2; AT591; CMT1D; CMT4E; KROX20; E3 SUMO-protein ligase EGR2; zinc finger protein Krox-20; early growth response protein 2; KROX-20, Drosophila, homolog (early growth response-2);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EGR2-777H Recombinant Human EGR2 Protein, His-tagged E.coli His
Human EGR2-28469TH Recombinant Human EGR2 Wheat Germ N/A 77 amino acids
Human EGR2-6976H Recombinant Human EGR2 protein, His & T7-tagged E.coli His/T7 Gly147~Cys403 (Accession # P11161)
Human EGR2-12329H Recombinant Human EGR2, GST-tagged E.coli GST 149-499a.a.
Human EGR2-3123H Recombinant Human EGR2 Protein, GST-tagged Wheat Germ GST
Human EGR2-6691HCL Recombinant Human EGR2 293 Cell Lysate HEK293 N/A
Human EGR2-2048H Recombinant Human EGR2 Protein (Gly147-Cys403), N-His tagged E.coli N-His Gly147-Cys403
Human EGR2-4266HF Recombinant Full Length Human EGR2 Protein, GST-tagged In Vitro Cell Free System GST 476 amino acids
Mouse EGR2-5053M Recombinant Mouse EGR2 Protein Mammalian Cell His
Mouse Egr2-30M Recombinant Mouse Egr2 protein, His-tagged E.coli His Gly150~Ser407
Mouse EGR2-2683M Recombinant Mouse EGR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EGR2-2683M-B Recombinant Mouse EGR2 Protein Pre-coupled Magnetic Beads HEK293
Rat EGR2-2033R Recombinant Rat EGR2 Protein Mammalian Cell His
Rat EGR2-1690R Recombinant Rat EGR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EGR2-1690R-B Recombinant Rat EGR2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EGR2-1400R Recombinant Rhesus monkey EGR2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EGR2-1225R Recombinant Rhesus Macaque EGR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EGR2-1225R-B Recombinant Rhesus Macaque EGR2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EGR2 Related Articles

EGR2 involved in several pathways and played different roles in them. We selected most pathways EGR2 participated on our site, such as Adipogenesis, BDNF signaling pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisKLF7A;HMGA1;MIXL1;KLF6A;BMP3;GTF3AA;GADD45A;NDN;HMGA1-RS1
BDNF signaling pathwayEIF4E;GNB2L1;FRS3;EIF4EBP1;MAP3K2;CDKL5;DPYSL2;CDK5;CFL1
Calcineurin-regulated NFAT-dependent transcription in lymphocytesIRF4;EGR4;IKZF1;EGR3;CSF2;BATF3;EGR1;DGKA;POU2F1
Developmental BiologyGFRA1;MYF6;DPYSL4;TCF3A;NR6A1;DUSP2;MED31;SIAH2;CHL1
HTLV-I infectionRELB;HRAS;XIAP;NRAS;KAT2A;MYB;PCNA;SFPI1;HLA-DRB3
Hepatitis BTGFBR1;PIK3R2;CCNE1;Casp3;STAT6;Ifna11;CCNA1;PIK3R3;PIK3CD
IL4-mediated signaling eventsRETNLB;MYB;CCL26;IRF4;TFF3;NIPAL1;EGR2;IgG3;DOK2
Transcriptional regulation of white adipocyte differentiationMED9;CDK19;MED29;MED18;MED19;NR2F2;EBF1;EGR2;MED22

EGR2 has several biochemical functions, for example, HMG box domain binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR2 itself. We selected most functions EGR2 had, and list some proteins which have the same functions with EGR2. You can find most of the proteins on our site.

Function Related Protein
HMG box domain bindingSP1;ALX4;OLIG2;POU3F3;EGR2;GATA3;HOXA3;JUN;HHEX
RNA polymerase II activating transcription factor bindingTBX20;TBX3;NFE2L2;ATF2;TP53BP1;ISL1;SETD3;LDB1;EOMES
RNA polymerase II core promoter proximal region sequence-specific DNA bindingPRDM5;ATF4;MYBL1;CEBPZ;MYBL2;ESRRA;KDM6A;FOS;POU1F1
chromatin bindingGATA3;KLF6A;OVOL2;PHF13;ARID3C;SOX9;ARX;MITF;CHAF1B
ligase activityTTC3;TRIM33;BARD1;UBE2L3B;RNF14;MID1;HERC5;UBE4B;TRIM71
metal ion bindingDDAH1;ZFP524;MAN1A;FUZ;ABAT;PKM;PVALB7;PPM1DA;VPS29
protein bindingITGB2;CTPS2;PAXIP1;ACTN4;METTL1;DPP4;BAZ1B;CCDC41;ZKSCAN5
transcription factor activity, sequence-specific DNA bindingTARDBP;POU5F1;SHOX;CDX2;SOX9;HOXC8;HOXB8A;FOXN2B;IRF3
transcription regulatory region DNA bindingHDAC1;SIX1;FOS;HOXA13;GATA3;TAF7L;IKZF4;FOXM1;OVOL2
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSOX2;GLIS2;FLI1;POU4F2;HOXC13;ALS2CR8;KLF4;EBF1;HOXA10
ubiquitin protein ligase bindingTRAF4;DIO2;IKBKE;SMAD2;DBT;TP53;BAG4;TNFRSF1B;KDM4A

EGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR2.

NDUFS2; BPGM; ACP5; HCFC1; RPL7L1; RBM15B; HN1L; RIMKLB; MED31; Nab2

Okamura, T; Sumitomo, S; et al. TGF-beta 3-expressing CD4(+)CD25(-)LAG3(+) regulatory T cells control humoral immune responses. NATURE COMMUNICATIONS 6:-(2015).
Pletinckx, K; Vaeth, M; et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-)IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. EUROPEAN JOURNAL OF IMMUNOLOGY 45:480-491(2015).
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