|Official Full Name||eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa|
|Background||Eukaryotic translation initiation factor 2 subunit 1?is a?protein?that in humans is encoded by the?EIF2S1?gene. Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.|
|Synonyms||EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eukaryotic translation initiation factor 2 subunit 1; eIF-2-alpha; OTTHUMP00000028404; OTTHUMP00000218025; eukaryotic translation initiation factor 2 subunit alpha|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
EIF2S1 involved in several pathways and played different roles in them. We selected most pathways EIF2S1 participated on our site, such as ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ABC-family proteins mediated transport||ABCA4A; EIF2S1A; CFTR; ABCD3B; ABCF1; ABCA7; ABCA8; ABCB8; ABCE1; EIF2S3|
|Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S||EIF2S1A; EIF4A2; EIF1AX; EIF2S3; EIF2S1; EIF4G1; EIF4B; EIF4EBP1; EIF3K; EIF4E|
|BDNF signaling pathway||JAK2; CNR1; EIF4EBP1; CFL1; LINGO1; EGR1; GRIP1; CDH2; FRS2; EEF2|
|Cap-dependent Translation Initiation||EIF4EBP1; EIF2B1; EIF1AX; EIF4A2; EIF1AXA; EIF4G1; EIF4B; EIF2S1; FAUB; EIF4A1|
|Eukaryotic Translation Initiation||EIF2S3; EIF4EB; EIF2B1; EIF2S1; EIF4A2; FAUB; EIF3K; EIF5; EIF1AX; RPL35|
|Formation of the ternary complex, and subsequently, the 43S complex||EIF2S1A; EIF1AXA; EIF1AX; EIF3K; EIF2S3; EIF2S1; FAUB|
|GTP hydrolysis and joining of the 60S ribosomal subunit||EIF2S1; EIF4H; EIF4A1; EIF4B; EIF2S3; RPL35; EIF1AX; EIF1AXA; EIF4A2; EIF2S1A|
|Gene Expression||TPRKB; C2orf49; EIF4B; PPARAA; CHD4; RRAGB; TP53RK; CSTF1; FARSB; ZNF584|
EIF2S1 has several biochemical functions, for example, poly(A) RNA binding, protein binding, ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2S1 itself. We selected most functions EIF2S1 had, and list some proteins which have the same functions with EIF2S1. You can find most of the proteins on our site.
|poly(A) RNA binding||SNRPN; PTCD3; PABPC1; SLBP; PHF5A; HMGB2; KPNB1; MRPL42; TCP1; EIF3G|
|protein binding||CPEB3; TNFSF13B; WNT3; SCRIB; CREB3; SESTD1; CERS2; FAM200A; NOX1; PLUNC|
|ribosome binding||CPEB2; CPEB3; C12orf65; MTRF1L; RPSA; RPN2; EIF3K; EIF2S1; ICT1; ERI1|
|translation initiation factor activity||EIF2A; EIF4EB; EIF4A1A; EIF2S1B; EIF3BA; EIF3J; EIF1B; MTIF2; EIF3JA; EIF4G3|
EIF2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2S1.
EIF2AK2; Eif2ak3; DDX3X; EIF2S2; EIF4G2; Dlg4