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EIF2S1

  • Official Full Name

    eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

  • Overview

    Eukaryotic translation initiation factor 2 subunit 1?is a?protein?that in humans is encoded by the?EIF2S1?gene. Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
  • Synonyms

    EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eukaryotic translation initiation factor 2 subunit 1; eIF-2-alpha; OTTHUMP00000028404; OTTHUMP00000218025; eukaryotic translation initiation factor 2 subunit alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF2S1-12361H Recombinant Human EIF2S1, GST-tagged E.coli GST 1-315a.a.
Human EIF2S1-3172H Recombinant Human EIF2S1 Protein, GST-tagged Wheat Germ GST
Human EIF2S1-371H Recombinant Human EIF2S1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EIF2S1-2501H Recombinant Human EIF2S1, His-tagged E.coli His
Human EIF2S1-542HCL Recombinant Human EIF2S1 cell lysate N/A
Human EIF2S1-3542H Recombinant Human EIF2S1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EIF2S1-4949HF Active Recombinant Full Length Human EIF2S1 Protein, GST-tagged E.coli GST 1-315(end)
Human EIF2S1-820H Recombinant Human EIF2S1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EIF2S1-4186HF Recombinant Full Length Human EIF2S1 Protein, GST-tagged In Vitro Cell Free System GST 315 amino acids
Human EIF2S1-820H-B Recombinant Human EIF2S1 Protein Pre-coupled Magnetic Beads HEK293
Human EIF2S1-2052H Recombinant Human EIF2S1 Protein (Met1-Thr239), N-His tagged E.coli N-His Met1-Thr239
Human EIF2S1-262HFL Recombinant Full Length Human EIF2S1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse EIF2S1-5087M Recombinant Mouse EIF2S1 Protein Mammalian Cell His
Mouse EIF2S1-2706M Recombinant Mouse EIF2S1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EIF2S1-2706M-B Recombinant Mouse EIF2S1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Eif2s1-2775M Recombinant Mouse Eif2s1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat EIF2S1-2052R Recombinant Rat EIF2S1 Protein Mammalian Cell His
Rat EIF2S1-1709R Recombinant Rat EIF2S1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF2S1-1709R-B Recombinant Rat EIF2S1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EIF2S1-1419R Recombinant Rhesus monkey EIF2S1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EIF2S1-1243R Recombinant Rhesus Macaque EIF2S1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EIF2S1-1243R-B Recombinant Rhesus Macaque EIF2S1 Protein Pre-coupled Magnetic Beads HEK293
Chicken EIF2S1-1616C Recombinant Chicken EIF2S1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF2S1 Related Articles

EIF2S1 involved in several pathways and played different roles in them. We selected most pathways EIF2S1 participated on our site, such as ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC-family proteins mediated transportAPOA1B;ABCF1;ABCA4A;EIF2S3;EIF2S1;ABCC2;ABCB8;CFTR;ABCD3B
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SFAUB;EIF4EB;EIF4H;EIF2S1;EIF3K;EIF4A1;EIF4B;EIF4E;EIF1AX
BDNF signaling pathwayEEF2;GNB2L1;FRS3;IGF2BP1;CSNK2A1;CDKL5;EGR2;SIRPA;EIF4E
Cap-dependent Translation InitiationEIF2S3;FAUB;EIF5;RPL35;EIF2S1;EIF2S1A;EIF4E;EIF4EB;EIF4A1
Eukaryotic Translation InitiationEIF2S1A;EIF4H;EIF1AX;EIF3K;EIF2B1;EIF4A2;EIF4B;EIF4A1;EIF2S1
Formation of the ternary complex, and subsequently, the 43S complexEIF1AXA;EIF1AX;EIF2S3;EIF3K;EIF2S1A;EIF2S1;FAUB
GTP hydrolysis and joining of the 60S ribosomal subunitEIF4B;EIF2S1A;EIF3K;EIF1AXA;EIF4A2;EIF2S3;EIF5;EIF4H;EIF4A1
Gene ExpressionZNF274;IPO8;DNMT3L;TFB2M;TXNL4A;ZNF707;C2orf29;TACO1;PEAK1

EIF2S1 has several biochemical functions, for example, poly(A) RNA binding, protein binding, ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2S1 itself. We selected most functions EIF2S1 had, and list some proteins which have the same functions with EIF2S1. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingNOVA2;NUFIP2;PPHLN1;C1orf53;RPL17;SLIRP;DDX41;MRPL14;CCDC124
protein bindingRPL19;TACC3;ING5;ATF3;UGGT1;LAMA4;XK;ANKRD32;MAPK10
ribosome bindingEIF5A2;RPN2;ETF1A;CPEB1;CPEB1A;EFTUD1;MTRF1;EIF5A;EIF2S1
translation initiation factor activityEIF4E;EIF4A1B;EIF1B;EIF3JA;EIF3S10;EIF4BB;EIF2S3Y;MTIF3;EIF4E2RS1

EIF2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2S1.

EIF2AK2; Eif2ak3; DDX3X; EIF2S2; EIF4G2; Dlg4

Vlahakis, A; Powers, T; et al. A role for TOR complex 2 signaling in promoting autophagy. AUTOPHAGY 10:2085-2086(2014).
Zhang, XN; Yuan, Y; et al. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury Involvement of PARK2-dependent mitophagy. AUTOPHAGY 10:1801-1813(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How is the expression of EIF2S1 regulated? 10/27/2022

The expression of EIF2S1 gene is affected by a variety of factors, including nutrients, growth factors, hormones, stress status, etc. Its expression regulation mainly occurs at the transcriptional level and the post-transcriptional level.

How does the EIF2S1 gene interact with RNA polymerase? 08/31/2021

The protein encoded by the EIF2S1 gene can bind to RNA polymerase to form a translation initiation complex, thus participating in the translation process of mRNA.

What is the main function of the EIF2S1 gene in cells? 08/21/2021

The protein encoded by the EIF2S1 gene is a subunit of the translation initiation factor eIF-2, which is involved in the initiation of the protein translation process in the cell.

What is the effect of EIF2S1 gene on apoptosis? 01/19/2021

Studies have shown that EIF2S1 gene may play an important role in the process of apoptosis, but its specific mechanism of action still needs further research.

What role does the EIF2S1 gene play in the cell cycle and cell differentiation? 07/21/2020

The EIF2S1 gene lays an important role in the cell cycle and cell differentiation, and is involved in the regulation of cell growth, division and differentiation.

Are there different subtypes or variants of the EIF2S1 gene? 01/08/2020

Yes, there are different isoforms or variants of the EIF2S1 gene, and these variants may have different functions and expression patterns.

Customer Reviews (3)

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Reviews
09/17/2023

    EIF2S1 was used to find high purity and no significant impurities.

    08/23/2023

      It was observed that its expression level was high, which was able to meet the needs of the experiment.

      04/01/2021

        Its stability is good, and there is no obvious change in the process of storage and transportation.

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