eif3a
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  • Official Full Name
  • eukaryotic translation initiation factor 3, subunit A
  • Background
  • Eukaryotic translation initiation factor 3 subunit A is a protein that in humans is encoded by the EIF3A gene. EIF3A has been shown to interact with EIF3EIP, EIF4B, DISC1, FBXO32, EIF3D, EIF3C, EIF4G2, EIF3B, EIF3J, EIF3S6, EIF3F, EIF3G, EIF3H, EIF3I and EIF3K.
  • Synonyms
  • eif3a; eukaryotic translation initiation factor 3, subunit A; ncl; eif3; tif32; eif3s10; Nucleolin; eIF3-p170; eif3-theta; nucleolin; Eukaryotic translation initiation factor 3 subunit 10; oocyte nuclear protein
Cat.#:EIF3A-3177HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF3A Protein, GST-tagged
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Cat.#:Eif3a-1929MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Eif3a protein, His & T7-tagged
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Cat.#:EIF3A-5091MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF3A Protein
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Cat.#:EIF3A-2055RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EIF3A Protein
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Cat.#:EIF3A-6664HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EIF3A 293 Cell Lysate
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Involved Pathway

EIF3A involved in several pathways and played different roles in them. We selected most pathways EIF3A participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF3A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport
EIF3C; POM121L2; EIF1AY; EIF4BB; STRAP; SENP2; NUP88; EIF2S2; EIF4EBP3L; RPP38

Protein Function

EIF3A has several biochemical functions, for example, poly(A) RNA binding, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF3A itself. We selected most functions EIF3A had, and list some proteins which have the same functions with EIF3A. You can find most of the proteins on our site.
Function
Related Protein
Function poly(A) RNA binding
Related Protein EIF3L; LUC7L2; GTPBP10; C9orf114; ANXA2; RPL12; PTPN1; HDLBP; DHX29; MKI67IP
Function protein binding
Related Protein HIRIP3; YIPF3; MPP5; KIAA0408; NXF1; SLC25A6; AEN; MOBP; NDEL1; NPY2R
Function structural molecule activity
Related Protein PNN; CLDNC; LAMA5; SNTB1; DCTN3; CLTCB; KRT18; CLDN15LA; NEFMA; KRT34
Function contributes_to translation initiation factor activity
Related Protein EIF3HB; EIF3H; EIF3BA; EIF3B; EIF3E; EIF2B5; EIF2B4; EIF3L; EIF3C; EIF3G

Interacting Protein

EIF3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF3A here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF3A.
EIF3B; EIF4B; UPF1; EIF3H; KRT7; EIF3F

EIF3A Related Articles

Yin, JY; Meng, XG; et al. Association of positively selected eIF3a polymorphisms with toxicity of platinum-based chemotherapy in NSCLC patients. ACTA PHARMACOLOGICA SINICA 36:375-384(2015).
Aylett, CHS; Boehringer, D; et al. Structure of a Yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex. NATURE STRUCTURAL & MOLECULAR BIOLOGY 22:269-271(2015).