EIF4A3
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Official Full Name
eukaryotic translation initiation factor 4A3
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Overview
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. -
Synonyms
EIF4A3; eukaryotic translation initiation factor 4A3; DDX48, DEAD (Asp Glu Ala Asp) box polypeptide 48 , eukaryotic translation initiation factor 4A, isoform 3; eukaryotic initiation factor 4A-III; EIF4AIII; KIAA0111; NMP 265; hNMP 265; eIF4A-III; eIF-4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- EIF4A3 Related Signal Pathway
EIF4A3 involved in several pathways and played different roles in them. We selected most pathways EIF4A3 participated on our site, such as RNA transport, mRNA surveillance pathway, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF3S10;XPOT;EIF3B;NUP98;EIF3G;RPP21;EIF1;POM121L2;CLNS1A |
| mRNA surveillance pathway | RNMT;NXF2;ETF1;WIBG;PPP2CB;PPP2R2B;PPP1CA;CPSF2;FIP1L1 |
| Spliceosome | USP39;SF3B5;SARNP;EFTUD2;TXNL4A;EIF4A3;WBP11;HSPA2;PHF5A |
EIF4A3 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A3 itself. We selected most functions EIF4A3 had, and list some proteins which have the same functions with EIF4A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PIKFYVE;IGF1R;MOV10B.1;GATC;TP53RK;MCMDC2;MAT2AA;NLRP7;RAF1 |
| ATP-dependent RNA helicase activity | TDRD12;DDX19;G3BP1;TMEM38A;DDX49;DHX35;DDX27;DHX8;DDX56 |
| mRNA binding | CSTF2;ITM2B;CSTF3;RPL13A;FXR1;ELAVL1;FMR1;KIAA0020;RBM38 |
| poly(A) RNA binding | C14orf93;ZFP36;POLDIP3;PARN;ESF1;YBX1;POU5F1;FAM98B;YWHAG |
| poly(A) binding | RBPMS;PABPC1;HNRNPDL;TIA1;KHDRBS1;DDX3X;KHDRBS2;SYNCRIP;PABPN1 |
| protein binding | TRIM6;SSTR2;TCF12;CD46;PID1;CDK8;DSCAM;PPP2R3A;DYNAP |
EIF4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A3.
RBM8A
- Q&As
- Reviews
Q&As (7)
Ask a questionSpecific RNA targets or motifs recognized by EIF4A3 include splice sites and exon junctions, with functional significance in maintaining mRNA integrity.
EIF4A3 is predominantly localized in the nucleus and cytoplasm of cells, contributing to its involvement in RNA-related processes.
EIF4A3 contributes to the regulation of RNA metabolism by participating in splicing, translation initiation, and mRNA surveillance.
There are potential therapeutic implications related to EIF4A3 in diseases involving RNA metabolism, making it a target for drug development.
EIF4A3 influences the balance between mRNA quality control, including nonsense-mediated decay, and translation efficiency.
Eukaryotic translation initiation factor 4A3 (EIF4A3) primarily functions in cellular processes, playing a role in RNA metabolism, including splicing and translation.
Dysregulation or abnormal expression of EIF4A3 is associated with conditions such as cancer and neurodegenerative disorders.
Customer Reviews (3)
Write a reviewThe product's user-friendly features facilitated seamless collaboration among team members with different expertise levels.
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