eif4a3
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  • Official Full Name
  • eukaryotic translation initiation factor 4A3
  • Background
  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.
  • Synonyms
  • EIF4A3; eukaryotic translation initiation factor 4A3; DDX48, DEAD (Asp Glu Ala Asp) box polypeptide 48 , eukaryotic translation initiation factor 4A, isoform 3; eukaryotic initiation factor 4A-III; EIF4AIII; KIAA0111; NMP 265; hNMP 265; eIF4A-III; eIF-4
Cat.#:EIF4A3-2494HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EIF4A3 Protein, GST-tagged
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Cat.#:EIF4A3-12377HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4A3, GST-tagged
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Cat.#:EIF4A3-1334HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Eukaryotic Translation Initiation Factor 4A3, His-tagged
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Cat.#:EIF4A3-27410THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EIF4A3, His-tagged
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Cat.#:EIF4A3-5104MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EIF4A3 Protein
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Cat.#:EIF4A3-2065RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EIF4A3 Protein
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Cat.#:EIF4A3-489CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EIF4A3 Protein, His-tagged
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Cat.#:EIF4A3-1427RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EIF4A3 Protein, His-tagged
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Cat.#:EIF4A3-2356CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EIF4A3
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Cat.#:EIF4A3-11304ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EIF4A3
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Cat.#:EIF4A3-6652HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EIF4A3 293 Cell Lysate
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Involved Pathway

EIF4A3 involved in several pathways and played different roles in them. We selected most pathways EIF4A3 participated on our site, such as RNA transport, mRNA surveillance pathway, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport
PABPC5; EIF3EA; NUPL1; NUP62; POP1; EIF4E2; POP7; XPOT; SUMO3; EIF2B3
mRNA surveillance pathway
CPSF5; CPSF7; RBM8A; CSTF2T; PPP2R2A; NXF2; PABPC1L2A; PPP2R1B; PPP2R5C; BCL2L2-PABPN1
Spliceosome
SRSF6A; PPIE; CDC5L; MAGOHB; DDX42; SRSF5B; HSPA1B; SYF2; HSPA1A; PUF60A

Protein Function

EIF4A3 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A3 itself. We selected most functions EIF4A3 had, and list some proteins which have the same functions with EIF4A3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PKDCCA; TIMM44; UCK2A; TAE1; ATP9B; CKM; CASKB; CDC42BPG; KALRN; TEC
Function ATP-dependent RNA helicase activity
Related Protein EIF4A2; DDX23; DDX50; DDX55; EIF4A1A; BAT1; EIF4A1B; DDX17; DDX3Y; DHX8
Function mRNA binding
Related Protein LUC7L3; RPS13; RPL35; CSTF2; RBM38; LUC7L; RPS3; RBFOX1; SOSTDC1B; RPL7
Function poly(A) RNA binding
Related Protein SERPINH1; ISG20L2; CS; EIF3G; SNRNP70; GPATCH8; ZFR; TRNAU1AP; RRP7A; ZCCHC17
Function poly(A) binding
Related Protein ZC3H14; TIA1; KHDRBS1; PABPC4; PAIP2B; PABPN1; HNRNPDL; RBPMS; EIF4A3; PABPC1
Function protein binding
Related Protein AP4B1; CYP2S1; Pilrb1; NPBWR2; SIX3; MALL; VPS72; CACFD1; GIP; QKI

Interacting Protein

EIF4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A3.
RBM8A