EIF5B Protein, eukaryotic translation initiation factor 5B

EIF5B

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EIF5B

Official Full Name eukaryotic translation initiation factor 5B
Background Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.
Synonyms EIF5B; eukaryotic translation initiation factor 5B; DKFZp434I036; FLJ10524; IF2; KIAA0741; translation initiation factor IF2; eIF 5B; eIF-5B; IF2P_HUMAN; Translation initiation factor IF 2; Translation initiation factor IF-2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF5B-3217H Recombinant Human EIF5B Protein, GST-tagged Wheat Germ GST
    Human EIF5B-546HCL Recombinant Human EIF5B cell lysate N/A
    Mouse EIF5B-5118M Recombinant Mouse EIF5B Protein Mammalian Cell His
    Rat EIF5B-2071R Recombinant Rat EIF5B Protein Mammalian Cell His
    Rhesus Macaque EIF5B-1435R Recombinant Rhesus monkey EIF5B Protein, His-tagged Mammalian Cell His
    Chicken EIF5B-3311C Recombinant Chicken EIF5B Mammalian Cell His

    EIF5B involved in several pathways and played different roles in them. We selected most pathways EIF5B participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport PABPC5; EIF3F; EIF4EBP2; DDX20; TGS1; NUP37; THOC1; CYFIP2; NUP133; UBE2IB

    EIF5B has several biochemical functions, for example, GTP binding, GTPase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF5B itself. We selected most functions EIF5B had, and list some proteins which have the same functions with EIF5B. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding RAB2A; MB21D1; ERAS; RAC1B; SAR1AB; TUBA1L; RAB1BB; RHOH; RHOGB; DNM2A
    GTPase activity EEFSEC; RAB24; TUBA3C; GNL1; ARF3; GNAO1A; ARL1; RHOF; RAB6C; RAB26
    poly(A) RNA binding PCSK9; SLC3A2; PTRF; RPL31; ACAA2; GLRX3; TNS1; MEX3B; RBMX; MRPL28
    protein binding CD5; JAKMIP2; PKMYT1; APBB2; PHIP; MCM3; TSR2; ZC3H18; RFX5; PRPF31
    translation initiation factor activity EIF3B; EIF2S2; EIF3HA; EIF3S6IP; EIF4E1B; EIF4E3; MTIF2; EIF2S1B; EIF3F; GTPBP1

    EIF5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF5B here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF5B.

    ETS1; EIF1AY; CSNK2A1; NR3C1; PRKAA1; SMAD2; NELL1; PIH1D1; ssrna_ag; MAPK13; XRCC3; FN1; Eif3a; HDGF; CBX1; SNW1; BECN1

    Pan, YF; Li, QF; et al. Genes associated with thermosensitive genic male sterility in rice identified by comparative expression profiling. BMC GENOMICS 15:-(2014).
    Lee, S; Truesdell, SS; et al. Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E4315-E4322(2014).

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