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EIF5B

  • Official Full Name

    eukaryotic translation initiation factor 5B

  • Overview

    Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.
  • Synonyms

    EIF5B; eukaryotic translation initiation factor 5B; DKFZp434I036; FLJ10524; IF2; KIAA0741; translation initiation factor IF2; eIF 5B; eIF-5B; IF2P_HUMAN; Translation initiation factor IF 2; Translation initiation factor IF-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF5B-3217H Recombinant Human EIF5B Protein, GST-tagged Wheat Germ GST
Human EIF5B-546HCL Recombinant Human EIF5B cell lysate N/A
Human EIF5B-3469H Recombinant Human EIF5B protein, His-tagged E.coli His 871-1220 aa
Mouse EIF5B-5118M Recombinant Mouse EIF5B Protein Mammalian Cell His
Mouse EIF5B-2727M-B Recombinant Mouse EIF5B Protein Pre-coupled Magnetic Beads HEK293
Mouse EIF5B-2727M Recombinant Mouse EIF5B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF5B-2071R Recombinant Rat EIF5B Protein Mammalian Cell His
Rat EIF5B-1728R Recombinant Rat EIF5B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF5B-1728R-B Recombinant Rat EIF5B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EIF5B-1435R Recombinant Rhesus monkey EIF5B Protein, His-tagged Mammalian Cell His
Rhesus Macaque EIF5B-1259R Recombinant Rhesus Macaque EIF5B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EIF5B-1259R-B Recombinant Rhesus Macaque EIF5B Protein Pre-coupled Magnetic Beads HEK293
Chicken EIF5B-3311C Recombinant Chicken EIF5B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF5B Related Articles

EIF5B involved in several pathways and played different roles in them. We selected most pathways EIF5B participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA transportNCBP2;NXF1;EIF3J;EIF5B;GEMIN4;NUP205;NXF2;EIF3EB;RPP21

EIF5B has several biochemical functions, for example, GTP binding, GTPase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF5B itself. We selected most functions EIF5B had, and list some proteins which have the same functions with EIF5B. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAB19;RAB6A;RAB5C;SEPT12;RAB35B;TUBA3E;GNAI3;RRAGCA;RAB7A
GTPase activityGNAT1;RABL5;RRAGD;TUBA8L3;RALAB;GNL1;ARHGAP5;GNB5;RAB42B
poly(A) RNA bindingACTN4;ZMAT3;TFAM;HSD17B10;MRPL3;RRP1;MRPL42;LLPH;ADD1
protein bindingFAM207A;PDE1B;MCCC2;JUNB;PPP2R5A;PHOSPHO2-KLHL23;CDK16;IRF2;UCHL5
translation initiation factor activityEIF5B;AGO2;EIF3S10;EIF2A;EIF1AD;EIF2S3;EIF2B5;EIF1AXB;EIF1B

EIF5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF5B here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF5B.

ETS1; EIF1AY; CSNK2A1; NR3C1; PRKAA1; SMAD2; NELL1; PIH1D1; ssrna_ag; MAPK13; XRCC3; FN1; Eif3a; HDGF; CBX1; SNW1; BECN1

Pan, YF; Li, QF; et al. Genes associated with thermosensitive genic male sterility in rice identified by comparative expression profiling. BMC GENOMICS 15:-(2014).
Lee, S; Truesdell, SS; et al. Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E4315-E4322(2014).
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