eomes
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  • Official Full Name
  • eomesodermin
  • Background
  • This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
  • Synonyms
  • EOMES; eomesodermin; TBR2; eomesodermin homolog; T-box brain protein 2;
Cat.#:EOMES-3345HTag:Myc/DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human EOMES Protein, Myc/DDK-tagged
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Cat.#:EOMES-3344HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EOMES Protein, GST-tagged
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Cat.#:EOMES-1649HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EOMES protein, His & GST-tagged
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Cat.#:EOMES-389HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EOMES Protein, His-tagged
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Cat.#:EOMES-5228MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EOMES Protein
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Cat.#:EOMES-6589HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EOMES 293 Cell Lysate
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Involved Pathway

EOMES involved in several pathways and played different roles in them. We selected most pathways EOMES participated on our site, such as Downstream signaling in naive CD8+ T cells, IL12-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EOMES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Downstream signaling in naive CD8+ T cells
EGR4; EOMES; EGR1; JUNB
IL12-mediated signaling events
HLX; GADD45G; EOMES

Protein Function

EOMES has several biochemical functions, for example, DNA binding, RNA polymerase II activating transcription factor binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EOMES itself. We selected most functions EOMES had, and list some proteins which have the same functions with EOMES. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein TBX4; NKX3.3; TRIM26; SIX6A; RPL7; ZNF70; POLR3D; PA2G4; HIST1H2BH; ZNF19
Function RNA polymerase II activating transcription factor binding
Related Protein CREB1; ISL1; CREBBP; NHLH2; EP300; EOMES; SIN3A; IFI27; BHLHE40; TBX20
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein EGR1; ZSCAN20; ZBTB12.2; NME2; ZNF583; GATA2B; GATA3; IKZF3; ZFY1; AASS
Function chromatin binding
Related Protein FEZF2; PHF13; APITD1; PROP1; RAN; C10orf119; ATF2; GATA5; WACA; CBX4
Function sequence-specific DNA binding
Related Protein HOXB2; CEBPG; HOXD11; DMRT3A; HOXD4; PRRX1A; LHX5; POU3F2B; FOXI1; DLX6A
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZIC1; ATOH8; ONECUT3; FOXC1B; TWIST2; MEOX2; SLC25A46; CLOCK; ZSCAN4C; IRF3
Function transcriptional repressor activity, RNA polymerase II transcription factor binding
Related Protein AHRR; AHRRB; MLIP; PITX2; BHLHE40; ELP2; EOMES; T; RIMKLB; MINA

Interacting Protein

EOMES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EOMES here. Most of them are supplied by our site. Hope this information will be useful for your research of EOMES.
PFDN1; sgrR; purR2

EOMES Related Articles

Kim, K; Bang, SY; et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
Chen, SH; Lee, LF; et al. Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model. CANCER IMMUNOLOGY RESEARCH 3:149-160(2015).