EPHA3 Protein, EPH receptor A3

EPHA3

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EPHA3

Official Full Name EPH receptor A3
Background Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal andhippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
Synonyms EPHA3; EPH receptor A3; EphA3 , ETK, ETK1, TYRO4; ephrin type-A receptor 3; HEK; HEK4; EPH-like kinase 4; human embryo kinase 1; eph-like tyrosine kinase 1; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor ETK1; EK4; ETK; ETK1; TYRO4
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • GST
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Epha3-955M Recombinant Mouse Epha3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human EPHA3-1218HCL Recombinant Human EPHA3 cell lysate Human Cell N/A
    Human EPHA3-1880H Recombinant Human EPH Receptor A3, His-tagged E.coli His
    Human EPHA3-1901H Recombinant Human EPHA3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EPHA3-26440TH Recombinant Human EPHA3 N/A
    Human EPHA3-301H Recombinant Human EPH Receptor A3, GST-tagged, Active Sf9 Insect Cell GST
    Human EPHA3-3380H Recombinant Human EPHA3 Protein, GST/His-tagged Insect Cell GST/His
    Human EPHA3-3381H Recombinant Human EPHA3 Protein, GST-tagged Insect Cell GST
    Human EPHA3-3382H Recombinant Human EPHA3 Protein, GST-tagged Wheat Germ GST
    Human EPHA3-363H Recombinant Human EPHA3 Protein, DDK/His-tagged HEK293 DDK/His
    Human EPHA3-364H Recombinant Human EPHA3 Protein, DDK-tagged Insect Cell DDK
    Human EPHA3-365H Recombinant Human EPHA3 Protein, DDK/His-tagged HEK293 DDK/His
    Human EPHA3-559H Recombinant Human EPHA3 Protein, Fc Chimera NS0 Fc
    Human EPHA3-8547H Recombinant Human EPHA3, His tagged Human Cell Fc/His
    Mouse EPHA3-001MCL Recombinant Mouse EPHA3 cell lysate Human Cell N/A
    Mouse EPHA3-002MCL Recombinant Mouse EPHA3 cell lysate Insect Cell N/A
    Mouse Epha3-1723M Recombinant Mouse Eph Receptor A3 NSO N/A
    Mouse EPHA3-180M Recombinant Mouse Epha3, His-GST tagged Insect Cell Fc/His
    Mouse Epha3-493M Recombinant Mouse Epha3 Insect Cell N/A
    Mouse Epha3-494M Recombinant Mouse Epha3, Fc-tagged Human Cell Fc
    Mouse Epha3-495M Recombinant Mouse Epha3, His-tagged Human Cell His
    Rat EPHA3-001RCL Recombinant Rat EPHA3 cell lysate Human Cell N/A
    Rat Epha3-551R Recombinant Rat Epha3, Fc-tagged Human Cell Fc
    Rat Epha3-552R Recombinant Rat Epha3, His-tagged Human Cell His
    Chicken EPHA3-6981C Recombinant Chicken EPHA3 Mammalian Cell His

    EPHA3 involved in several pathways and played different roles in them. We selected most pathways EPHA3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance LIMK1; PLXNB2; CDK5R1B; NFATC4; SDCBP; EPHB3; ARPC1A; NRG4; COL9A3; EZRA

    EPHA3 has several biochemical functions, for example, ATP binding, GPI-linked ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHA3 itself. We selected most functions EPHA3 had, and list some proteins which have the same functions with EPHA3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding BMX; KIF5C; PRKACBB; INSRR; FPGS; MLKL; PLK2; H1FNT; PEX6; ADCY1
    GPI-linked ephrin receptor activity EK1; EPHA5; EPHA4; EPHA8; EPHA3; EPHA7
    protein binding MPDZ; CHCHD3; GFOD1; CALCRL; PCBD1; MICA; KLC3; FATE1; RFWD3; AKT1S1

    EPHA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHA3.

    ephopt; optyf; EPHA7; SRPK1; RBM18; CDKN2A; RUFY1

    Swords, RT; Wei, AH; et al. KB004, a Novel Non-Fucosylated Humaneered (R) Antibody, Targeting EphA3, Is Active and Well Tolerated in a Phase I/II Study of Advanced Hematologic Malignancies. BLOOD 124:-(2014).
    Tomasevic, N; Luehrsen, K; et al. A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity. GROWTH FACTORS 32:223-235(2014).

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