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  • Official Full Name
  • v-ets avian erythroblastosis virus E26 oncogene homolog
  • Background
  • This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewings sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
  • Synonyms
  • ERG; v-ets avian erythroblastosis virus E26 oncogene homolog; p55; erg-3; transcriptional regulator ERG; ets-related; TMPRSS2/ERG fusion; v-ets erythroblastosis virus E26 oncogene like; v-ets erythroblastosis virus E26 oncogene homolog; v-ets avian erythroblastosis virus E26 oncogene related; transcriptional regulator ERG (transforming protein ERG);
Cat.#:ERG-1389HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ERG Protein (1-486 aa), His-tagged
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Cat.#:ERG-3469HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERG Protein, GST-tagged
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Cat.#:ERG-210HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERG protein, T7/His-tagged
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Cat.#:ERG-28690THTag:Flag|His
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ERG, GST-tagged
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Cat.#:ERG-5295MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ERG Protein
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Cat.#:ERG-5853CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ERG
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Cat.#:ERG-1906ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ERG
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Cat.#:ERG-6559HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ERG 293 Cell Lysate
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Cat.#:ERG-6560HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ERG 293 Cell Lysate
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Involved Pathway

ERG involved in several pathways and played different roles in them. We selected most pathways ERG participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Transcriptional misregulation in cancer
PAX3; HIST1H3H; CDK14; GZMB; PER2; SS18; RXRG; ELK4; DDX5; HIST1H3F

Protein Function

ERG has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERG itself. We selected most functions ERG had, and list some proteins which have the same functions with ERG. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZBTB42; ZNF726; POLRMT; TMF1; ID2B; MB21D1; EBF3A; MGAA; TFAP2B; NKX1.2LA
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein ZNF202; FOXR2; SP4; FOXG1D; ZNF488; JUNB; GATA6; FOXS1; SOX9A; RUNX2B
Function chromatin binding
Related Protein NR5A5; KLHDC3; TOX4; PSIP1; PHF8; CITED2; TOP2A; CBX5; NCOA2; MLL1
Function protein binding
Related Protein LRR1; HLA-A; FAM164C; MCM6; ADAM1B; RPL27A; TAL1; RAB35; E2F7; COG8
Function sequence-specific DNA binding
Related Protein ARX; NFIL3-2; HOXB4; SALL4; TBX5A; OTX1A; FLI1B; DMRT3; DLX4; DBX1A
Function signal transducer activity
Related Protein OPN1MW4; TICAM2; V2RH32; GNAO1B; VALOPA; MTNR1AA; FAM126A; TRADD; GNG3; PLCB3

Interacting Protein

ERG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERG here. Most of them are supplied by our site. Hope this information will be useful for your research of ERG.
AR; PARP1; fkbp5_human_gene; klk3_human_gene; tmps2_human_gene

ERG Related Articles

Shon, W; Folpe, AL; et al. ERG expression in chondrogenic bone and soft tissue tumours. JOURNAL OF CLINICAL PATHOLOGY 68:125-129(2015).
Brenn, T; et al. Cutaneous angiosarcoma. New aspects. PATHOLOGE 36:70-77(2015).