| Description : |
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
51.9 kDa |
| AA Sequence : |
MIQTVPDPAAHIKEALSVVSEDQSL FECAYGTPHLAKTEMTASSSSDYGQ TSKMSPRVPQQDWLSQPPARVTIKM ECNPSQVNGSRNSPDECSVAKGGKM VGSPDTVGMNYGSYMEEKHMPPPNM TTNERRVIVPADPTLWSTDHVRQWL EWAVKEYGLPDVNILLFQNIDGKEL CKMTKDDFQRLTPSYNADILLSHLH YLRETPLPHLTSDDVDKALQNSPRL MHARNTDLPYEPPRRSAWTGHGHPT PQSKAAQPSPSTVPKTEDQRPQLDP YQILGPTSSRLANPGSGQIQLWQFL LELLSDSSNSSCITWEGTNGEFKMT DPDEVARRWGERKSKPNMNYDKLSR ALRYYYDKNIMTKVHGKRYAYKFDF HGIAQALQPHPPESSLYKYPSDLPY MGSYHAHPQKMNFVAPHPPALPVTS SSFFAAPNPYWNSPTGGIYPNTRLP TSHMPSHLGTYYSGPTRTRRLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
