• Official Full Name
  • eukaryotic translation termination factor 1
  • Background
  • This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]
  • Synonyms
  • ETF1; eukaryotic translation termination factor 1; ERF; RF1; ERF1; TB3-1; D5S1995; SUP45L1; eukaryotic peptide chain release factor subunit 1; protein Cl1; polypeptide chain release factor 1; sup45 (yeast omnipotent suppressor 45) homolog-like 1;
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ETF1 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ETF1, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ETF1 protein, His & T7-tagged
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ETF1
Source (Host):HEK293Species:Human
Product nameRecombinant Human ETF1 protein, MYC/DDK-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ETF1 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ETF1 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human ETF1 293 Cell Lysate

Involved Pathway

ETF1 involved in several pathways and played different roles in them. We selected most pathways ETF1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETF1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA surveillance pathway

Protein Function

ETF1 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETF1 itself. We selected most functions ETF1 had, and list some proteins which have the same functions with ETF1. You can find most of the proteins on our site.
Related Protein
Function RNA binding
Related Protein YTHDC2; CNOT6; RBFOX1; EIF2S2; NANOS3; IFIT12; PABPN1L; CWC22; DCP2; IREB2
Function poly(A) RNA binding
Related Protein PPIG; VCP; MRPL40; RBM7; HNRNPL; MECP2; SND1; PPP1R2P9; RRP8; RRS1
Function protein binding
Related Protein NCOA2; TMEM8A; C7orf53; SLC6A3; KRT6B; GRM6; NR0B1; DHX15; TSKS; THOC7
Function ribosome binding
Related Protein ETF1B; EIF5A; ERI1; EIF2A; EIF2S1; EIF6; SBDS; BAG6; MTOR; MTRF1
Function translation release factor activity
Related Protein ETF1; GSPT1L; GSPT2; MTRF1
Function translation release factor activity, codon specific
Related Protein ETF1B; ETF1A; ETF1; MTRF1; MTRF1L
Function translation termination factor activity
Related Protein ETF1

Interacting Protein

ETF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETF1.
KEAP1; GSPT1; a8k1f4_human; MLF1; PSMD2; IKBKE; TRMT10C; GSPT2; FKBPL; TRAF6; Mphosph9; FGFR1OP; ALB; VCAM1