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ETF1

  • Official Full Name

    eukaryotic translation termination factor 1

  • Overview

    This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]
  • Synonyms

    ETF1; eukaryotic translation termination factor 1; ERF; RF1; ERF1; TB3-1; D5S1995; SUP45L1; eukaryotic peptide chain release factor subunit 1; protein Cl1; polypeptide chain release factor 1; sup45 (yeast omnipotent suppressor 45) homolog-like 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ETF1-1397H Recombinant Human ETF1 protein, His & T7-tagged E.coli His/T7 Ala2~Val221 (Accession # P62495)
Human ETF1-28695TH Recombinant Human ETF1 Wheat Germ N/A 100 amino acids
Human ETF1-3514H Recombinant Human ETF1 Protein, GST-tagged Wheat Germ GST
Human ETF1-12564H Recombinant Human ETF1, GST-tagged E.coli GST 1-404a.a.
Human ETF1-5893H Recombinant Human ETF1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ETF1-6533HCL Recombinant Human ETF1 293 Cell Lysate HEK293 N/A
Human ETF1-4731HF Recombinant Full Length Human ETF1 Protein, GST-tagged In Vitro Cell Free System GST 437 amino acids
Human ETF1-4411HFL Recombinant Full Length Human ETF1 protein, Flag-tagged Mamanlian cells Flag
Human ETF1-3650H Recombinant Human ETF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Etf1-2878M Recombinant Mouse Etf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ETF1-2158R Recombinant Rat ETF1 Protein Mammalian Cell His
Rat ETF1-1815R Recombinant Rat ETF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ETF1-1815R-B Recombinant Rat ETF1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ETF1-1508R Recombinant Rhesus monkey ETF1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ETF1-1333R-B Recombinant Rhesus Macaque ETF1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ETF1-1333R Recombinant Rhesus Macaque ETF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ETF1 involved in several pathways and played different roles in them. We selected most pathways ETF1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA surveillance pathwayPPP2R3C;PABPC1;EIF4A3;PPP1CC;SMG6;PAPOLG;ETF1;BAT1;PPP2R5C

ETF1 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETF1 itself. We selected most functions ETF1 had, and list some proteins which have the same functions with ETF1. You can find most of the proteins on our site.

Function Related Protein
RNA bindingSUZ12;RPS9;EIF2S1B;SNRPD1;TRIM71;SNRPF;RPL34;CNOT7;RPL31
poly(A) RNA bindingTDRD3;DDX39B;RPS17L;DUS3L;CSTF2T;RBMX;SAP18;CKAP4;NOA1
protein bindingSYN1;PRKD3;NUP35;BIRC5;CUL4B;SNX10;TRAPPC3;C8orf74;BLOC1S1
ribosome bindingSEC61A1;YTHDF1;RPN2;ETF1A;EIF2S1A;PPP1R2P9;C12orf65;BAG6;EIF5A2
translation release factor activityGSPT1L;MTRF1;GSPT2;ETF1
translation release factor activity, codon specificETF1;ETF1B;MTRF1;MTRF1L;ETF1A
translation termination factor activity

ETF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETF1.

KEAP1; GSPT1; a8k1f4_human; MLF1; PSMD2; IKBKE; TRMT10C; GSPT2; FKBPL; TRAF6; Mphosph9; FGFR1OP; ALB; VCAM1

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any ongoing clinical trials related to ETF1 protein disorders? 04/25/2023

There may be clinical trials evaluating potential treatments or interventions for ETF1 protein disorders, and individuals and families affected by these disorders can consider participating in such trials.

What are the symptoms of metabolic disorders caused by ETF1 protein dysfunction? 06/18/2022

Symptoms may include muscle weakness, lethargy, hypoglycemia, metabolic acidosis, and in some cases, developmental delays and neurological symptoms.

Can ETF1 protein disorders be detected before birth? 05/15/2019

Yes, prenatal testing through genetic screening can detect mutations in the ETF1 gene, allowing for early intervention and management.

How are ETF1 protein disorders diagnosed? 07/05/2018

Diagnosis typically involves biochemical testing, genetic testing, and metabolic screening to identify abnormalities in fatty acid metabolism.

Can ETF1 protein disorders affect individuals of all ages? 02/09/2017

Yes, ETF1 protein disorders can affect individuals of all ages, from newborns to adults, and may present with different symptoms at different stages of life.

Customer Reviews (3)

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Reviews
11/25/2022

    What sets this protein apart is the outstanding technical support provided by the manufacturer.

    09/20/2022

      Its versatility allows me to explore its diverse roles in various biochemical and biological processes accurately.

      07/18/2019

        The ETF1 Protein is of exceptional quality and is precisely tailored to meet my experimental requirements.

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