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EGLN1

  • Official Full Name

    egl-9 family hypoxia-inducible factor 1

  • Overview

    The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
  • Synonyms

    EGLN1; egl-9 family hypoxia-inducible factor 1; HPH2; PHD2; SM20; ECYT3; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2; egl nine homolog 1; egl nine-like protein 1; HIF prolyl hydroxylase 2; HIF-prolyl hydroxylase 2; zinc finger MYND domain-containing protein 6; hypoxia-inducible factor prolyl hydroxylase 2; prolyl hydroxylase domain-containing protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect cells
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EGLN1-126H Recombinant human EGLN1, GST tagged Wheat Germ GST
Human EGLN1-414H Recombinant Human EGLN1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EGLN1-12325H Recombinant Human EGLN1, GST-tagged E.coli GST 273-426a.a.
Human EGLN1-127H Recombinant Human EGLN1, MYC/DDK-tagged HEK293 Myc/DDK
Human EGLN1-6696HCL Recombinant Human EGLN1 293 Cell Lysate HEK293 N/A
Human EGLN1-001H Recombinant Human EGLN1 protein Insect cells FLAG
Human EGLN1-4080H Recombinant Human EGLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EGLN1-4795H Recombinant Human EGLN1 protein, His&Myc-tagged E.coli His&Myc 177-426aa
Human EGLN1-2025HFL Recombinant Full Length Human EGLN1, Flag-tagged Mamanlian cells Flag
Mouse EGLN1-5049M Recombinant Mouse EGLN1 Protein Mammalian Cell His
Mouse Egln1-497M Recombinant Mouse Egln1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse EGLN1-2680M Recombinant Mouse EGLN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EGLN1-2680M-B Recombinant Mouse EGLN1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

EGLN1 involved in several pathways and played different roles in them. We selected most pathways EGLN1 participated on our site, such as HIF- signaling pathway, Pathways in cancer, Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF- signaling pathwayTFRC;ENO3;IGF1R;NFKB1;MTOR;PRKCG;PLCG2;CAMK2D;MAP2K1
Pathways in cancerHIF1A;FZD1;MAX;AGTR1B;BDKRB2;TRAF2;FGFR1;BAX;TRAF1
Renal cell carcinomaPAK3;PIK3R3;FH1;EP300;MAPK3;PIK3CA;HRAS;VHL;ARAF

EGLN1 has several biochemical functions, for example, L-ascorbic acid binding, enzyme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGLN1 itself. We selected most functions EGLN1 had, and list some proteins which have the same functions with EGLN1. You can find most of the proteins on our site.

Function Related Protein
L-ascorbic acid bindingP4HA1B;TMLHE;LEPRE1;ALKBH3;OGFOD2;EGLN3;PLOD3;PAM;FAM125B
enzyme bindingAlb;KMT2E;PARK2;KPNB1;PRKCA;MDM4;NOTCH3;SCN5A;MAPK8
iron ion bindingNOS3;CYP2AA1;ALOX15;HBBE1.1;CYP2K17;ISCU;ALOX8;CYP2AA8;CYP2C19
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsKDM5BA;P4HTM;JHDM1D;KDM5D;ALKBH5;KDM5A;KDM5BB;ALKBH8;HIF1AN
peptidyl-proline 4-dioxygenase activityEGLN3;EGLN2;EGLN1
peptidyl-proline dioxygenase activityOGFOD1;EGLN1
protein bindingGALR2;PCSK5;LAGE3;PMM1;CSNK1G1;AGBL1;IFT43;Chrng;RDH12

EGLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGLN1.

HIF1A; FKBP8; EPAS1; OS9; PKM

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