epha1
Share
  • Official Full Name
  • EPH receptor A1
  • Background
  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
  • Synonyms
  • EPHA1; EPH receptor A1; EphA1 , EPHT, EPHT1; ephrin type-A receptor 1; EPH; hEpha1; oncogene EPH; eph tyrosine kinase 1; soluble EPHA1 variant 1; soluble EPHA1 variant 2; tyrosine-protein kinase receptor EPH; erythropoietin-producing hepatoma receptor; er
Cat.#:EPHA1-3374HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EPHA1 Protein, GST-tagged
+Inquiry
Cat.#:EPHA1-3375HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EPHA1 Protein, GST-tagged
+Inquiry
Cat.#:EPHA1-1608HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human EPH Receptor A1
+Inquiry
Cat.#:EPHA1-163HTag:Fc Chimera
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human EPHA1, Fc Chimera
+Inquiry
Cat.#:EPHA1-28577THTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EPHA1
+Inquiry
Cat.#:EPHA1-350HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EPHA1
+Inquiry
Cat.#:EPHA1-361HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA1 Protein, DDK/His-tagged
+Inquiry
Cat.#:EPHA1-362HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EPHA1 Protein, DDK-tagged
+Inquiry
Cat.#:EPHA1-6869HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EPHA1 protein, His & T7-tagged
+Inquiry
Cat.#:EPHA1-726HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA1 Protein, Fc-tagged
+Inquiry
Cat.#:EPHA1-727HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EPHA1 Protein, His-tagged
+Inquiry
Cat.#:EPHA1-743HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EPH Receptor A1, GST-His
+Inquiry
Cat.#:Epha1-349MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Epha1, His-tagged
+Inquiry
Cat.#:Epha1-6870MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Epha1 protein, His & T7-tagged
+Inquiry
Cat.#:Epha1-6923MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Epha1, His tagged
+Inquiry
Cat.#:EPHA1-5931CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EPHA1
+Inquiry
Cat.#:Epha1-299MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Epha1, GST-tagged, Active
+Inquiry
Cat.#:EPHA1-1400MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse EPHA1 (Active), GST-tagged
+Inquiry
Cat.#:EPHA1-1700MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EPHA1 cell lysate
+Inquiry

Involved Pathway

Epha1 involved in several pathways and played different roles in them. We selected most pathways Epha1 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
CLTB; SPRED1; ABLIM2; PAQR3B; EFNA4; SEMA7A; DPYSL5; COL6A2; SPTBN2; RND1

Protein Function

Epha1 has several biochemical functions, for example, ATP binding, protein kinase activity, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha1 itself. We selected most functions Epha1 had, and list some proteins which have the same functions with Epha1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MAPK11; PGK1; RFC5; MOV10B.2; LIG3; PRKCHA; ROCK2B; DDX54; SPATA5L1; STK32A
Function protein kinase activity
Related Protein CAMK2G1; AKT1; CCND1; PRKCHA; CAMK2D2; PAK2A; CAMKK1B; PIK3CG; LMTK3; JAK2
Function protein kinase binding
Related Protein SV2A; PRKAG3; CCNK; CAV1; NGFRAP1; ITGB1BP1; CACNB2; PTPRK; TPRKB; TRIM5
Function transmembrane-ephrin receptor activity
Related Protein EPHA5; EFNA4; EPHA1; EPHB1; EPHB2; EFNB3; EPHA10; EPHA4; EFNA3

Interacting Protein

Epha1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha1.
npm_alk; saicar; PKM; UBA1; UBE2N; UBE2V1; Map3k1; HSP90AB1

Epha1 Related Articles

Ieguchi, K; Tomita, T; et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. ONCOGENE 33:2179-2190(2014).
Herath, NI; Spanevello, MD; et al. Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis. EUROPEAN JOURNAL OF CANCER 48:753-762(2012).

Epha1 Related Gene Family

Cytokines