Epha1 Protein, EPH receptor A1

Epha1

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Epha1

Official Full Name EPH receptor A1
Background This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
Synonyms EPHA1; EPH receptor A1; EphA1 , EPHT, EPHT1; ephrin type-A receptor 1; EPH; hEpha1; oncogene EPH; eph tyrosine kinase 1; soluble EPHA1 variant 1; soluble EPHA1 variant 2; tyrosine-protein kinase receptor EPH; erythropoietin-producing hepatoma receptor; er
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • Fc Chimera
    • GST
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Epha1-953M Recombinant Mouse Epha1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human EPHA1-1608H Recombinant Human EPH Receptor A1 NSO N/A
    Human EPHA1-163H Recombinant Human EPHA1, Fc Chimera HEK293 Fc Chimera
    Human EPHA1-28577TH Recombinant Human EPHA1 Insect Cell N/A
    Human EPHA1-3374H Recombinant Human EPHA1 Protein, GST-tagged Insect Cell GST
    Human EPHA1-3375H Recombinant Human EPHA1 Protein, GST-tagged Wheat Germ GST
    Human EPHA1-350H Recombinant Human EPHA1 Mammalian Cell His
    Human EPHA1-361H Recombinant Human EPHA1 Protein, DDK/His-tagged HEK293 DDK/His
    Human EPHA1-362H Recombinant Human EPHA1 Protein, DDK-tagged Insect Cell DDK
    Human EPHA1-6869H Recombinant Human EPHA1 protein, His & T7-tagged E.coli His/T7
    Human EPHA1-726H Recombinant Human EPHA1 Protein, Fc-tagged HEK293 Fc
    Human EPHA1-727H Recombinant Human EPHA1 Protein, His-tagged HEK293 His
    Human EPHA1-743H Recombinant Human EPH Receptor A1, GST-His Sf9 Insect Cell GST
    Mouse EPHA1-1400M Recombinant Mouse EPHA1 (Active), GST-tagged Sf9 Insect Cell GST
    Mouse EPHA1-1700MCL Recombinant Mouse EPHA1 cell lysate Human Cell N/A
    Mouse Epha1-299M Recombinant Mouse Epha1, GST-tagged, Active Sf9 Insect Cell GST
    Mouse Epha1-349M Recombinant Mouse Epha1, His-tagged NS0 His
    Mouse Epha1-6870M Recombinant Mouse Epha1 protein, His & T7-tagged E.coli His/T7
    Mouse Epha1-6923M Recombinant Mouse Epha1, His tagged Human Cell His
    Chicken EPHA1-5931C Recombinant Chicken EPHA1 Mammalian Cell His

    Epha1 involved in several pathways and played different roles in them. We selected most pathways Epha1 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance SIAH2; PAK2; EFNB2; DPYSL3; ITSN1; CREB1B; SEMA6A; SLIT3; FGF20A; RHOA

    Epha1 has several biochemical functions, for example, ATP binding, protein kinase activity, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha1 itself. We selected most functions Epha1 had, and list some proteins which have the same functions with Epha1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NLK; PLK4; PHKG1A; SMC4; HSP90AB1; BRIP1; PTK2AA; ATP6V1AA; PRKCHB; ABCB3L1
    protein kinase activity NPR2; MAP3K3; EPHA4B; MAPK14B; NLK; RPS6KA3B; CLK2B; CDK14; MAP3K5; RAF1B
    protein kinase binding TRAF2; HDAC7; MAVS; CDKN2D; TRAF3; SHC1; GRB7; AKAP5; WAS; CDK5RAP1
    transmembrane-ephrin receptor activity EFNA4; EPHB1; EPHA5; EFNB3; EPHB2; EFNA3; EPHA1; EPHA4; EPHA10

    Epha1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha1.

    npm_alk; saicar; PKM; UBA1; UBE2N; UBE2V1; Map3k1; HSP90AB1

    Ieguchi, K; Tomita, T; et al. ADAM12-cleaved ephrin-A1 contributes to lung metastasis. ONCOGENE 33:2179-2190(2014).
    Herath, NI; Spanevello, MD; et al. Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis. EUROPEAN JOURNAL OF CANCER 48:753-762(2012).

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