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Official Full Name Fas-activated serine/threonine kinase
Background The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
Synonyms FASTK; Fas-activated serine/threonine kinase; FAST; Fas activated serine threonine kinase; Fas activated serine threonine kinase isoform 1; Fas activated serine threonine kinase isoform 4; FAST kinase; FLJ13079
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FASTK-1402H Recombinant Human FASTK (Active), GST-tagged Sf9 Insect Cell GST
    Human FASTK-3859H Recombinant Human FASTK Protein, GST-tagged Wheat Germ GST
    Human FASTK-6322HCL Recombinant Human FASTK 293 Cell Lysate HEK293 N/A
    Human FASTK-6323HCL Recombinant Human FASTK 293 Cell Lysate HEK293 N/A
    Human FASTK-721H Recombinant Human FASTK Protein, His-tagged E.coli His
    Human FASTK-801H Recombinant Human FASTK, GST-tagged Sf9 Insect Cell GST
    Human FASTK-824H Recombinant Human Fas-activated Serine/Threonine Kinase, T7-tagged E.coli T7
    Rat Fastk-722R Recombinant Rat Fastk Protein, His-tagged E.coli His
    Zebrafish FASTK-7653Z Recombinant Zebrafish FASTK Mammalian Cell His

    FASTK involved in several pathways and played different roles in them. We selected most pathways FASTK participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with FASTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    FASTK has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by FASTK itself. We selected most functions FASTK had, and list some proteins which have the same functions with FASTK. You can find most of the proteins on our site.

    Function Related Protein
    Fas-activated serine/threonine kinase activity FASTK
    protein binding POU3F2; ATP6V0D1; STUB1; CSPP1; NCAPH; CSRNP2; UQCRB; CFL1; PHOSPHO2-KLHL23; RNF126
    protein serine/threonine kinase activity SRPK1; ATM; ERN2; MAP2K3; ACVR2AA; DCAMKL2; PRKCZ; BMPR1A; MAP4K1; PASK

    FASTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASTK here. Most of them are supplied by our site. Hope this information will be useful for your research of FASTK.


    Jourdain, AA; Koppen, M; et al. A Mitochondria-Specific Isoform of FASTK Is Present In Mitochondrial RNA Granules and Regulates Gene Expression and Function. CELL REPORTS 10:1110-1121(2015).
    Zhi, F; Zhou, GX; et al. miR-106a-5p Inhibits the Proliferation and Migration of Astrocytoma Cells and Promotes Apoptosis by Targeting FASTK. PLOS ONE 8:-(2013).

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