fbl
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  • Official Full Name
  • fibrillarin
  • Background
  • This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
  • Synonyms
  • FBL; fibrillarin; rRNA 2-O-methyltransferase fibrillarin; FIB; FLRN; RNU3IP1; 34-kD nucleolar scleroderma antigen; 34 kDa nucleolar scleroderma antigen; RNA, U3 small nucleolar interacting protein 1; CG9888 gene product from transcript CG9888-RA; 34 kD nucleolar scleroderma antigen; FBRL_HUMAN; FIB1; Nop1p; rRNA 2 O methyltransferase fibrillarin; CG9888-PA; Fib-PA; CG9888; Dmel\CG9888; Fibri; GCR-6; GCR6; pen59C5
Cat.#:FBL-83HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibrillarin Protein, GST-tagged
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Cat.#:FBL-84HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibrillarin Protein, His-tagged
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Cat.#:FBL-3869HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FBL Protein, GST-tagged
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Cat.#:FBL-12762HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBL, His-tagged
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Cat.#:FBL-85HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBL Protein, His-tagged
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Cat.#:FBL-89HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBL Protein, GST-tagged
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Cat.#:FBL-5698MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FBL Protein
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Cat.#:FBL-2281RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FBL Protein
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Cat.#:Fbl-7817RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fbl protein, His & T7-tagged
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Cat.#:FBL-12246ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FBL
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Cat.#:FBL-791HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibrillarin, His-tagged
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Cat.#:FBL-6319HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FBL 293 Cell Lysate
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Involved Pathway

FBL involved in several pathways and played different roles in them. We selected most pathways FBL participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome biogenesis in eukaryotes
RPP40; NOP58; NOP10; IMP3; SMFN; RAN; FBL; RIOK2; WDR36; LOC81691

Protein Function

FBL has several biochemical functions, for example, ATPase binding, RNA binding, TFIID-class transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBL itself. We selected most functions FBL had, and list some proteins which have the same functions with FBL. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein ESR1; FXYD3; LCK; ZNHIT6; SDF2L1; DERL1; DRD1; ATP1B1; ATXN3; ATP6V1G3
Function RNA binding
Related Protein RPL21; ELAVL1; CNBPA; A1CF; HNRNPH3; RBMY1B; HNRNPH1; JAKMIP1; IFIT11; QKIA
Function TFIID-class transcription factor binding
Related Protein ERCC1; NOP58; ZNHIT6; FBL; ERCC4
Function histone-glutamine methyltransferase activity
Related Protein FBL
Function poly(A) RNA binding
Related Protein RPS7; RALYL; LRPPRC; RPS17; HNRNPU; MCAT; MRPL32; HNRNPAB; NQO1; YTHDF2
Function protein binding
Related Protein DPEP1; RAB22A; RASL11A; EDF1; MEI4; TOMM20; NOG; E2F4; BNIP2; GATA5
Function rRNA methyltransferase activity
Related Protein PRDM12; DIMT1; PRDM11; TRMT10C; METTL21D; RNMTL1B; FBL; FAM86; METTL23; METTL7B

Interacting Protein

FBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBL here. Most of them are supplied by our site. Hope this information will be useful for your research of FBL.
SMN1; ARRB2; DDX5; LOC100911617; Prmt3; Prmt1; Prmt1; RTCA; RIOK3; CFLAR; CIAO1

FBL Related Articles

Shih, TS; Her, I; et al. EMULATING THE HUMAN TIBIOFEMORAL JOINT BY USING A FOUR-BAR LINKAGE, CONDYLAR SHAPES AND SLIP RATIO VARIATION. INTERNATIONAL JOURNAL OF ROBOTICS & AUTOMATION 30:70-78(2015).
Hisamoto, N; Li, C; et al. The C-elegans HGF/Plasminogen-like Protein SVH-1 Has Protease-Dependent and -Independent Functions. CELL REPORTS 9:1628-1634(2014).