| Cat.No. : | FBL-83H |
| Product Overview : | Recombinant Human Fibrillarin Protein (1-321) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. |
| Description : | Human recombinant fibrillarin (residues 2-321; Genbank Accession # NM_001436; MW= 61.3 kDa) expressed as an N-terminal GST-fusion protein in E. coli. Fibrillarin is a component of nucleolar ribonucleoprotein complexes including snoRNPs (small nucleolar ribonucleoproteins) and Cajal bodies. As part of the C/D snoRNPs, fibrillarin functions as the catalytic subunit in the 2’-O methylation of ribosomal RNAs1. In addition, fibrillarin has recently been shown to catalyze methylation of histone H2A glutamine-104, a modification restricted to the nucleolus and linked to RNA Pol I transcriptional activity on rDNA3. A distinct protein subcomplex comprising fibrillarin, SF2A-p32 and the argininine methyltransferases PRMT1 and PRMT5 has been described4 and fibrillarin’s N-terminal glycine and arginine-rich (GAR) domain, including in the context of full-length fibrillarin5, is a substrate for various PRMTs. |
| Source : | E. coli |
| Species : | Human |
| Tag : | GST |
| Form : | 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10 % glycerol |
| Molecular Mass : | 60.3 kDa |
| Protein length : | 1-321 |
| Purity : | >95% by SDS-PAGE |
| Notes : | This product is NOT intended for therapeutic or diagnostic use in animals or in humans. |
| Storage : | Store at -70 centigrade. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended. |
| Gene Name : | FBL fibrillarin [ Homo sapiens ] |
| Official Symbol : | FBL |
| Synonyms : | FBL; fibrillarin; FIB; FLRN; RNU3IP1; |
| Gene ID : | 2091 |
| mRNA Refseq : | NM_001436 |
| Protein Refseq : | NP_001427 |
| MIM : | 134795 |
| UniProt ID : | P22087 |
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