|Official Full Name||F-box protein 11|
|Background||This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.|
|Synonyms||FBXO11; F-box protein 11; F box only protein 11; F-box only protein 11; FBX11; PRMT9; ubiquitin protein ligase E3 component n recognin 6; UBR6; vitiligo-associated protein 1; vitiligo-associated protein VIT-1; protein arginine N-methyltransferase 9; ubiqu|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
FBXO11 involved in several pathways and played different roles in them. We selected most pathways FBXO11 participated on our site, such as p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|p53 pathway||FBXO11; PPP1R13L; E4F1; RASSF1; CSNK1G3; KAT8; NEDD8; DYRK2; TTC5; TRIM28|
FBXO11 has several biochemical functions, for example, protein binding, protein-arginine N-methyltransferase activity, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO11 itself. We selected most functions FBXO11 had, and list some proteins which have the same functions with FBXO11. You can find most of the proteins on our site.
|protein binding||HSPA13; INTS10; INCENP; LUZP4; ADAP1; GATSL3; GNA14; RBM11; GSE1; CTAG2|
|protein-arginine N-methyltransferase activity||NDUFAF5; PRDM12; TRMT10C; DIMT1; PRDM13; METTL21D; RNMTL1A; METTL23; FBXO11; CARM1|
|ubiquitin-protein transferase activity||TRIM17; HECW2; TRAF4B; HECTD3; WDSUB1; TRIM56; ZNF738; BIRC8; UBE3A; UBE2L6|
|zinc ion binding||NPSN; TRIM41; PXN; RNF10; RNF34; CRIP1; PRICKLE1B; MECR; MYCBP2; TRIM24|
FBXO11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO11 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO11.
SKP1; TP53; SNAI1; UBE2M; NAE1; NEDD8; UBA3; TXN