fbxw4
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  • Official Full Name
  • F-box and WD repeat domain containing 4
  • Background
  • This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
  • Synonyms
  • FBXW4; F-box and WD repeat domain containing 4; F box and WD 40 domain protein 4 , SHFM3, split hand/foot malformation (ectrodactyly) type 3; F-box/WD repeat-containing protein 4; dactylin; Fbw4; DAC; F box and WD 40 domain containing protein 4; F box and WD 40 domain protein 4; F box and WD repeat domain containing 4; F box/WD repeat containing protein 4; F box/WD repeat protein 4; F-box and WD-40 domain-containing protein 4; FBW 4; FBWD 4; FBWD4; FBXW 4; FBXW4_HUMAN; OTTHUMP00000059175; SHFM 3; SHSF 3; SHSF3; Split hand/foot malformation (ectrodactyly) type; F-box/WD repeat protein 4; F-box and WD-40 domain protein 4; SHFM3
Cat.#:FBXW4-3971HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FBXW4 Protein, GST-tagged
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Cat.#:FBXW4-30064THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FBXW4, His-tagged
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Cat.#:FBXW4-5778MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FBXW4 Protein
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Cat.#:FBXW4-1671RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FBXW4 Protein, His-tagged
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Cat.#:FBXW4-9070ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FBXW4
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Cat.#:FBXW4-6284HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FBXW4 293 Cell Lysate
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Involved Pathway

FBXW4 involved in several pathways and played different roles in them. We selected most pathways FBXW4 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Association of TriC/CCT with target proteins during biosynthesis
FBXW4; CCT6A; CCT7; TCP1; FBXL5; CCT2; FBXW9; CCT8; CCT5; FKBP9
Chaperonin-mediated protein folding
FKBP9; TUBA1B; CCT3; CCT6A; PFDN6; CCT5; NOP56; CCT2; PFDN2; FBXW9
Metabolism of proteins
EID3; LMAN2L; MCFD2; SERP1; SAE1; SLC30A6; TRAPPC6B; NAT8B; KLK13; WDR85
Protein folding
PFDN1; TBCC; CCT6A; PFDN4; CCT7; NOP56; PFDN2; FBXW5; PFDN6; ARL2

Protein Function

FBXW4 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW4 itself. We selected most functions FBXW4 had, and list some proteins which have the same functions with FBXW4. You can find most of the proteins on our site.
Function
Related Protein
Function molecular_function
Related Protein FAM187A; CXX1B; XLR; PRF1.6; MIEF2; FAM210B; IFI27; TSGA14; EMILIN1A; V1RD19

Interacting Protein

FBXW4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW4.
SKP1; CUL1; CDC37; ECSIT; RNF32; MAST1; SLX4IP