|Official Full Name||ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)|
|Background||Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.|
|Synonyms||FCN3; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen); ficolin-3; FCNH; HAKA1; Collagen/fibrinogen domain containing lectin 3 p35; Collagen/fibrinogen domain containing protein 3; FCN 3; Ficolin (collagen/fibrinogen domain containing) 3; Ficolin 3; H ficolin; Hakata antigen; MGC22543; H-ficolin; OTTHUMP00000006338; OTTHUMP00000006339; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
FCN3 involved in several pathways and played different roles in them. We selected most pathways FCN3 participated on our site, such as Complement cascade, Creation of C4 and C2 activators, Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Complement cascade||CFHL3; IGKC; FCN3; IGKV1-5; FCN1; BFB; IgG3; CFD; IGLC2; RCA2.1|
|Creation of C4 and C2 activators||IgG3; HBL3; IGKC; IGKV1-5; CRP; FCN3; C1rb; MASP2; FCN1; FCN2|
|Ficolins bind to repetitive carbohydrate structures on the target cell surface||FCN2; FCN3; MASP2; FCN1|
|Immune System||DYNC1LI2; KIF11; PJA1; RNF216; DDOST; CLEC6A; ATG7; POLR3GLA; CLEC5A; HUWE1|
|Initial triggering of complement||GZMM; MASP2; FCN1; CFD; BFB; C1rb; FCN2; CRP; IgG3; FCN3|
|Innate Immune System||DEFB116; LRRFIP1; S100A12; AGER; TLR10; TXNIP; CASP4; DEFB125; WASF3; BTR02|
|Lectin pathway of complement activation||FCN2; FCN3; FCN1; HBL3|
FCN3 has several biochemical functions, for example, antigen binding, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCN3 itself. We selected most functions FCN3 had, and list some proteins which have the same functions with FCN3. You can find most of the proteins on our site.
|antigen binding||Ighg; CD40; TOPORS; MHC1UKA; PPP2R1A; LILRA2; Ighg2a; FCN3; HNRNPM; IGLC2|
|carbohydrate binding||CLEC3A; MGAT2; SIGLEC6; CHODL; CD55; PKD1L3; MAN2A1; REG1A; SIGLEC14; SELL|
|protein binding||PTPRG; ETS2; SH2B2; SMU1; BRMS1; ZUFSP; COMMD1; RAB43; BCL11B; CDC45|
FCN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCN3.