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FCN3

Official Full Name

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
Overview

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Synonyms

FCN3; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen); ficolin-3; FCNH; HAKA1; Collagen/fibrinogen domain containing lectin 3 p35; Collagen/fibrinogen domain containing protein 3; FCN 3; Ficolin (collagen/fibrinogen domain containing) 3; Ficolin 3; H ficolin; Hakata antigen; MGC22543; H-ficolin; OTTHUMP00000006338; OTTHUMP00000006339; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian cells
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FCN3-854H	Active Recombinant Human FCN3 Protein, His-tagged	Mammalian cells	His	Lys22-Arg288	Inquiry
Human	FCN3-4004H	Recombinant Human FCN3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FCN3-12827H	Recombinant Human FCN3, GST-tagged	E.coli	GST	20-288a.a.	$319 / 25ug
Human	FCN3-1949H	Recombinant Human FCN3 protein, His-tagged	E.coli	His	Glu34~Met297	Inquiry
Human	FCN3-614HCL	Recombinant Human FCN3 cell lysate		N/A		Inquiry
Human	FCN3-4766HF	Recombinant Full Length Human FCN3 Protein, GST-tagged	In Vitro Cell Free System	GST	288 amino acids	Inquiry
Human	FCN3-2893H	Recombinant Human FCN3 protein, His-tagged	E.coli	His	24-299aa	Inquiry
Human	FCN3-2937H-B	Recombinant Human FCN3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	FCN3-2937H	Recombinant Human FCN3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

FCN3 involved in several pathways and played different roles in them. We selected most pathways FCN3 participated on our site, such as Complement cascade, Creation of C4 and C2 activators, Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Complement cascade	FCN2;CRP;FCN1;BFB;IGLC2;IGKC;IGKV1-5;IgG3;HBL3
Creation of C4 and C2 activators	C1rb;IgG3;FCN1;HBL3;FCN3;IGLC2;IGKC;MASP2;FCN2
Ficolins bind to repetitive carbohydrate structures on the target cell surface	MASP2;FCN1;FCN2;FCN3
Immune System	GRAP2B;DUSP3B;AMICA1;EDARADD;CD300LG;PRLRB;WWP1;TRIM3;PJA2
Initial triggering of complement	HBL3;MASP2;BFB;CRP;FCN3;C1rb;GZMM;FCN1;CFD
Innate Immune System	UNC93B1;SIRPB1;TREM1;DEFB116;TLR10;CTSLL;CD300E;TREX1;CLEC4D
Lectin pathway of complement activation	FCN2;HBL3;FCN1;FCN3

FCN3 has several biochemical functions, for example, antigen binding, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCN3 itself. We selected most functions FCN3 had, and list some proteins which have the same functions with FCN3. You can find most of the proteins on our site.

Function	Related Protein
antigen binding	IgG3;PPP2R1A;LAG3;IGLL1;LILRA2;TSPAN4;Ighg2a;MHC1UKA;IGKV1-5
carbohydrate binding	PVRL1;SORD;CLEC9A;LGALS2B;LMAN2;CDIPT;MBL1;LGALSLA;CLEC2H
protein binding	LRPPRC;RBX1;FAM60A;CSRNP2;GPSM2;FBXO5;TNFRSF13B;TJAP1;FAM127C

FCN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCN3.