fgr
Share
  • Official Full Name
  • feline Gardner-Rasheed sarcoma viral oncogene homolog
  • Background
  • This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FGR; feline Gardner-Rasheed sarcoma viral oncogene homolog; SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr; tyrosine-protein kinase Fgr; p55-c-fgr protein; c-fgr protooncogene; proto-oncogene c-Fgr; c-src-2 proto-oncogene; proto-oncogene tyrosine-protein kinase FGR; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog;
Cat.#:FGR-4155HTag:GST|His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FGR Protein, GST/His-tagged
+Inquiry
Cat.#:FGR-4156HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGR Protein, GST-tagged
+Inquiry
Cat.#:FGR-5870MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGR Protein
+Inquiry
Cat.#:FGR-2343RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGR Protein
+Inquiry
Cat.#:FGR-1707RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FGR Protein, His-tagged
+Inquiry
Cat.#:FGR-317HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGR, GST-tagged, Active
+Inquiry
Cat.#:FGR-1406HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGR (Active), GST-tagged
+Inquiry
Cat.#:FGR-6228HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FGR 293 Cell Lysate
+Inquiry
Cat.#:Kit-1591Tag:N/A
Source (Host):Species:
Product nameFGR Activity Assay Kit
+Inquiry

Involved Pathway

FGR involved in several pathways and played different roles in them. We selected most pathways FGR participated on our site, such as Chemokine signaling pathway, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
SHC2; GRK6; GM1987; PIK3CD; CCL6; LOC100033925; NFKBIA; GNGT1; RASGRP2; CCL15
Epstein-Barr virus infection
POLR1C; HLA-DRB3; MAP2K6; SKP2; HLA-C; POLR3G; HLA-DQB1; PSMC4; YWHAH; YWHAB

Protein Function

FGR has several biochemical functions, for example, ATP binding, Fc-gamma receptor I complex binding, immunoglobulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGR itself. We selected most functions FGR had, and list some proteins which have the same functions with FGR. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein AFG3L2; RBKS; HIPK3; BMPR2; MAP4K4; HELLS; PRKCBB; EPHA1; LIG3; SYK
Function Fc-gamma receptor I complex binding
Related Protein FGR; FLNA
Function immunoglobulin receptor binding
Related Protein IgG3; Ighg2a; IGLC2; FGR; Ighg2b; CLEC4D; IGKC; IGLL1; FES; Ighg
Function non-membrane spanning protein tyrosine kinase activity
Related Protein TYK2; TNK1; BAZ1B; PTK6B; PTK2B; ABL2; MATK; CSK; TNK2B; TXK
Function phosphotyrosine binding
Related Protein SHC1; SAMSN1; FGR; CBLC; CBL; GRB2; STAP1; ZAP70; PTPN3; LDLRAP1
Function protein binding
Related Protein SIX4; CEP120; TNFRSF10A; CCDC106; ZFP64; TMEM8B; SSR1; OLIG3; C1orf116; MED7
Function protein kinase binding
Related Protein CCNB1; IBTK; SLC12A7; FOXM1; MAPK8IP2; PKD1; PDCD10; AP2A1; CEP68; TRIM6
Function protein tyrosine kinase activity
Related Protein CAMKK2; CLK3; WEE2; MAP2K4; DYRK1B; FGR; NTRK2B; KIT; ZAP70; PTK6B

Interacting Protein

FGR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGR here. Most of them are supplied by our site. Hope this information will be useful for your research of FGR.
HSP90AB1; EGFR; ERBB2; MET; ALOX5; AR; KIT; WAS; EEF1A2; ABI1; abl-tide

FGR Related Articles

Abu Shehab, M; Damerill, I; et al. Liver mTOR Controls IGF-I Bioavailability by Regulation of Protein Kinase CK2 and IGFBP-1 Phosphorylation in Fetal Growth Restriction. ENDOCRINOLOGY 155:1327-1339(2014).
Deng, L; Kitova, EN; et al. Mapping Protein-Ligand Interactions in the Gas Phase Using a Functional Group Replacement Strategy. Comparison of CID and BIRD Activation Methods. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 24:988-996(2013).