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FHL2

  • Official Full Name

    four and a half LIM domains 2

  • Overview

    Proteins containing LIM domains (which are double zinc finger motifs implicated in protein binding) are important regulators of cell growth, cell differentiation, and remodeling of the cell cytoskeleton. Human Four-and-a-half LIM-only protein 2 (FHL2), al
  • Synonyms

    FHL2; four and a half LIM domains 2; four and a half LIM domains protein 2; DRAL; SLIM3; LIM domain protein DRAL; aging-associated gene 11; skeletal muscle LIM-protein 3; four and a half LIM-domain protein 2; down-regulated in rhabdomyosarcoma LIM protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FHL2-634H Recombinant Human four and a half LIM domains 2, His-tagged E.coli His
Human FHL2-793H Recombinant Human FHL2 Protein, His-tagged E.coli His
Human FHL2-6223HCL Recombinant Human FHL2 293 Cell Lysate HEK293 N/A
Human FHL2-6224HCL Recombinant Human FHL2 293 Cell Lysate HEK293 N/A
Human FHL2-4162H Recombinant Human FHL2 Protein, GST-tagged Wheat Germ GST
Human FHL2-6618H Recombinant Human FHL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FHL2-2938H Recombinant Human FHL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FHL2-6633H Recombinant Human FHL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FHL2-4958HF Recombinant Full Length Human FHL2 Protein, GST-tagged In Vitro Cell Free System GST 279 amino acids
Mouse FHL2-5876M Recombinant Mouse FHL2 Protein Mammalian Cell His
Mouse Fhl2-3012M Recombinant Mouse Fhl2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FHL2-3251M Recombinant Mouse FHL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FHL2-3251M-B Recombinant Mouse FHL2 Protein Pre-coupled Magnetic Beads HEK293
Rat FHL2-2345R Recombinant Rat FHL2 Protein Mammalian Cell His
Rat FHL2-2001R-B Recombinant Rat FHL2 Protein Pre-coupled Magnetic Beads HEK293
Rat FHL2-2001R Recombinant Rat FHL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FHL2 Related Articles
  • FHL2 Related Research Area

FHL2 involved in several pathways and played different roles in them. We selected most pathways FHL2 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FHL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Osteoclast differentiationSFPI1;TYK2;CALCR;TGFB1;NOX1;FCGR1;LILRA4;NFATC1;AKT2

FHL2 has several biochemical functions, for example, androgen receptor binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FHL2 itself. We selected most functions FHL2 had, and list some proteins which have the same functions with FHL2. You can find most of the proteins on our site.

Function Related Protein
androgen receptor bindingTRIM68;CCNE1;PARK7;DDX5;PRKCB;KDM4C;PKN1;FOXH1;TGFB1I1
identical protein bindingROBO1;CD28;PLK4;PVRL2;GLUL;MSTN;LEPR;STAC3;TP63
protein bindingTBX5;PAK3;EWSR1;TTR;FAM20A;ROCK2;PINK1;C14orf93;WDR4
transcription coactivator activityTFAP2A;LPIN3;GTF2F1;SUB1B;MED14;MAX;SAP130;MED21;MYCBP
transcription factor bindingPAX6;PSMD10;EP300;PYDC3;TRP53;FOS;PIAS1;DR1;Ar
zinc ion bindingSIRT5;ADAM17A;FNTB;PCGF6;RNPEP;TIMM10;EDEM3;RNF220;MID2

FHL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FHL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FHL2.

BRCA1; RFX3; GNG12; FOXO1

Verset, L; Tommelein, J; et al. Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer. BRITISH JOURNAL OF CANCER 109:114-120(2013).
Huss, S; Stellmacher, C; et al. Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. BMC GASTROENTEROLOGY 13:-(2013).
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