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FMOD

  • Official Full Name

    fibromodulin

  • Overview

    Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix.
  • Synonyms

    FMOD; fibromodulin; fibromodulin proteoglycan; SLRR2E; Collagen binding 59 kDa protein; Fibromodulin precursor; Keratan sulfate proteoglycan fibromodulin; KSPG fibromodulin; FM; OTTHUMP00000034098; collagen-binding 59 kDa protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FMOD-82H Active Recombinant Human FMOD protein, His-tagged Mammalian cells His 302
Human FMOD-933H Recombinant Human FMOD Protein, His-tagged E.coli His Gln19~Ile376
Human FMOD-12947H Recombinant Human FMOD, GST-tagged E.coli GST 1-376a.a.
Human FMOD-3993H Recombinant Human FMOD Protein, Fc-tagged HEK293 Fc Met1-Ile376
Human FMOD-893H Recombinant Human FMOD Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FMOD-6180HCL Recombinant Human FMOD 293 Cell Lysate HEK293 N/A
Human FMOD-3032H Recombinant Human FMOD Protein (Gln19-Ile376), His tagged E.coli His Gln19-Ile376
Human FMOD-927H Recombinant Human FMOD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FMOD-4395H Recombinant Human FMOD Protein, GST-tagged Wheat Germ GST
Human FMOD-912H Recombinant Human FMOD protein, His-tagged E. coli His 1-376 aa
Human FMOD-2179H Recombinant Human FMOD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FMOD-4995HF Recombinant Full Length Human FMOD Protein, GST-tagged In Vitro Cell Free System GST 376 amino acids
Human FMOD-131HFL Active Recombinant Full Length Human FMOD Protein, C-Flag-tagged Mammalian cells Flag
Human FMOD-927H-B Recombinant Human FMOD Protein Pre-coupled Magnetic Beads HEK293
Mouse FMOD-5944M Recombinant Mouse FMOD Protein Mammalian Cell His
Mouse FMOD-3294M-B Recombinant Mouse FMOD Protein Pre-coupled Magnetic Beads HEK293
Mouse Fmod-3057M Recombinant Mouse Fmod Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FMOD-3294M Recombinant Mouse FMOD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FMOD-2371R Recombinant Rat FMOD Protein Mammalian Cell His
Rat Fmod-7043R Recombinant Rat Fmod protein, His-tagged E.coli His Gln19~Ile376
Rat FMOD-2027R-B Recombinant Rat FMOD Protein Pre-coupled Magnetic Beads HEK293
Rat FMOD-2027R Recombinant Rat FMOD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FMOD-1732R Recombinant Rhesus monkey FMOD Protein, His-tagged Mammalian Cell His
Rhesus Macaque FMOD-1554R Recombinant Rhesus Macaque FMOD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FMOD-1554R-B Recombinant Rhesus Macaque FMOD Protein Pre-coupled Magnetic Beads HEK293
Chicken FMOD-6526C Recombinant Chicken FMOD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FMOD Related Articles
  • FMOD Related Research Area

FMOD involved in several pathways and played different roles in them. We selected most pathways FMOD participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMOD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)OGN;KERA;ACAN;PRELP;FMOD
Defective CHST6 causes MCDC1KERA;OGN;ACAN;FMOD;PRELP
Defective ST3GAL3 causes MCT12 and EIEE15ACAN;FMOD;OGN;PRELP;KERA
DiseaseWHSC2;NPM1;APOBEC3G;AP2A1;NUP35;HMGA1;MMAA;DPF1;GPC5
Diseases associated with glycosaminoglycan metabolismPRELP;KERA;ACAN;FMOD;OGN
Diseases of glycosylationACAN;OGN;PRELP;FMOD;KERA
ECM proteoglycansASPN;MATN3B;VCANB;BGNB;COL9A3;MATN3;COL9A1;MUSK;MATN4
Extracellular matrix organizationTLL1;COL5A1;ADAMTS5;MUSK;FN1B;MMP8;TPSAB1;COL5A3A;DMP1

FMOD has several biochemical functions, for example, NOT Roundabout binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMOD itself. We selected most functions FMOD had, and list some proteins which have the same functions with FMOD. You can find most of the proteins on our site.

Function Related Protein
NOT Roundabout bindingFMODA;EPYC;FMOD;OGN
heparin bindingCTSG;CECR1;FGF7;APLP1;CLEC3B;C6orf25;LRPAP1;VEGFAA;GM4980

FMOD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMOD here. Most of them are supplied by our site. Hope this information will be useful for your research of FMOD.

Dlg4; b4dyc6_human; thiF

Adini, I; Adini, A; et al. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB JOURNAL 29:662-670(2015).
Johnson, JS; Morscher, MA; et al. Gene Expression Differences Between Ruptured Anterior Cruciate Ligaments in Young Male and Female Subjects. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME 97A:71-79(2015).
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