Active Recombinant Full Length Human FMOD Protein, C-Flag-tagged

• Cat.No.: FMOD-131HFL
• Product Overview: Recombinant Full Length Human FMOD Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Cell treatment
• Molecular Mass: 41.2 kDa
• AA Sequence: MQWTSLLLLAGLFSLSQAQYEDDPH WWFHYLRSQQSTYYDPYDPYPYETY EPYPYGVDEGPAYTYGSPSP PDPRDCPQECDCPPNFPTAMYCDNR NLKYLPFVPSRMKYVYFQNNQITSI QEGVFDNATGLLWIALHGNQ ITSDKVGRKVFSKLRHLERLYLDHN NLTRMPGPLPRSLRELHLDHNQISR VPNNALEGLENLTALYLQHN EIQEVGSSMRGLRSLILLDLSYNHL RKVPDGLPSALEQLYMEHNNVYTVP DSYFRGAPKLLYVRLSHNSL TNNGLASNTFNSSSLLELDLSYNQL QKIPPVNTNLENLYLQGNRINEFSI SSFCTVVDVVNFSKLQVLRL
  DGNEIKRSAMPADAPLCLRLASLIE ITRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein

Gene Information

• Gene Name: FMOD fibromodulin [ Homo sapiens (human) ]
• Official Symbol: FMOD
• Synonyms: FM; SLRR2E
• Gene ID: 2331
• mRNA Refseq: NM_002023.5
• Protein Refseq: NP_002014.2
• MIM: 600245
• UniProt ID: Q06828