| Description : |
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
43.2 kDa |
| AA Sequence : |
MQWTSLLLLAGLFSLSQAQYEDDPH WWFHYLRSQQSTYYDPYDPYPYETY EPYPYGVDEGPAYTYGSPSPPDPRD CPQECDCPPNFPTAMYCDNRNLKYL PFVPSRMKYVYFQNNQITSIQEGVF DNATGLLWIALHGNQITSDKVGRKV FSKLRHLERLYLDHNNLTRMPGPLP RSLRELHLDHNQISRVPNNALEGLE NLTALYLQHNEIQEVGSSMRGLRSL ILLDLSYNHLRKVPDGLPSALEQLY MEHNNVYTVPDSYFRGAPKLLYVRL SHNSLTNNGLASNTFNSSSLLELDL SYNQLQKIPPVNTNLENLYLQGNRI NEFSISSFCTVVDVVNFSKLQVLRL DGNEIKRSAMPADAPLCLRLASLIE ITRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
