FOXO1
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Official Full Name
FOXO1 forkhead box O1 -
Synonyms
FOXO1;forkhead box O1;FKHR, forkhead homolog in rhabdomyosarcoma , FOXO1A;forkhead box protein O1;FKH1;forkhead box protein O1A;forkhead, Drosophila, homolog of, in rhabdomyosarcoma;FKHR;FOXO1A
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- HEK293
- E.coli
- Mammalian Cells
- Wheat Germ
- HT-1080
- DDK
- Myc
- His
- Non
- Flag
- Avi
- Fc
- GST
Involved Pathway
FOXO1 involved in several pathways and played different roles in them. We selected most pathways FOXO1 participated on our site, such as FoxO signaling pathway,AMPK signaling pathway,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | ACACB,PPP2R5D,PPP2R2C,PFKP,CCND1,PIK3R1,Scd2,CAMKK1,RAB10,RAB2A |
| Pathways in cancer | RXRG,BCL2,FZD7,TCF7L2,WNT3,FGF14,RARB,CTNNA3,BIRC7,SLC2A1 |
| Insulin resistance | PRKCD,NFKB1,PYGB,PTPRFB,PRKAA2,IRS2,NFKBIAA,PRKAG2A,CREB3L2,PTENB |
| Prostate Cancer | AKT1,CCND1,IKBKG,Pdgfa&Pdgfb,MAPK1,NFKB1,BAD,INS1,SPINK1,ERBB2 |
| Thyroid hormone signaling pathway | HDAC1,PLCB3,PIK3CG,CASP9,MED17,MED4,PLCB2,NCOR1,FXYD2,GATA4 |
| Transcriptional misregulation in cancer | MYCN,LYL1,MEN1,ITGAM,PAX5,PPARG,TAF15,LDB1,KDM6A,TRP53 |
| FoxO signaling pathway | SMAD2,SGK2A,FOXG1A,INS2,S1PR4,TGFBR1A,HRASA,INSRA,FOXO1A,CDKN2D |
| Insulin signaling pathway | RPS6KB1,SOCS4,INSRB,RAPGEF1B,RHOQ,CBLC,MAP2K2A,INPPL1,SHC3,IKBKB |
Protein Function
FOXO1 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXO1 itself. We selected most functions FOXO1 had, and list some proteins which have the same functions with FOXO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | TFDP1,FOXH1,ZNF202,SIM1B,ZNF174,FOXI2,SOX8A,ZSCAN18,MAZ,EPAS1B |
| ubiquitin protein ligase binding | SQSTM1,UBE2V1,EGFR,SPG20,UBE2S,UBE2Z,LTBR,FZD5,ARIH1,UBE2W |
| protein phosphatase 2A binding | IGBP1,TP53,PPP2R4,STRN4,SMG7,RPS6KB1,PPP2R2A,ANKLE2,ENSA,STRN |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | CC2D1A,JDP2,DLX4,NFE2L3,E2F8,PITX2,GZF1,ETS2,BHLHE40,GATA3 |
| transcription factor binding | EPN1,SOX8,UBE2I,TP53,APBB1,NBN,GATA2,TAF12,NEUROD1,GATA4 |
| protein binding | CALML3,MARK2,PNMA2,C1orf109,TRIM29,NAT10,PLEKHA1,SH3PXD2B,YWHAQ,ARMC8 |
| sequence-specific DNA binding | TCF7L1B,FOXG1D,ZKSCAN4,ZNF500,HOXB1A,NKX2-5,NR3C2,SPI1B,OTX1A,NR2F6B |
| chromatin binding | TCF7L1A,HIST2H3C1,MEOX1,ZEB1,REL,TICRR,C19orf40,CBX5,SMARCA2,COQ7 |
| transcription factor activity, transcription factor binding | LDB1B,CRY1,PER1,TP63,LDB2A,PER2,ASCL1,LDB1A,ASCL1B,MTA2 |
Interacting Protein
FOXO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXO1.
CDK1;FHL2;CCNB1;SET
FOXO1 Related Signal Pathway
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References
- Ko, KI; Coimbra, LS; et al. Diabetes reduces mesenchymal stem cells in fracture healing through a TNF alpha-mediated mechanism. DIABETOLOGIA 58:633-642(2015).
- Stone, EL; Pepper, M; et al. ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation. IMMUNITY 42:239-251(2015).
