FOXO1
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Official Full Name
FOXO1 forkhead box O1
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Synonyms
FOXO1; forkhead box O1; FKHR, forkhead homolog in rhabdomyosarcoma , FOXO1A; forkhead box protein O1; FKH1; forkhead box protein O1A; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FKHR; FOXO1A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FOXO1 Related Articles
- FOXO1 Related Research Area
- FOXO1 Related Signal Pathway
FOXO1 involved in several pathways and played different roles in them. We selected most pathways FOXO1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | MAP2K2B;G6PC2;PRKAB1A;EP300;KLF2;PIK3CA;CCNG2;CCNB3;KLF2A |
| AMPK signaling pathway | PDPK1;PCK2;IRS1;STK11;CAB39;MAP3K7;RPS6KB1;TSC1;HNF4A |
| Insulin signaling pathway | PPP1CAA;INSRB;ACACB;HK3;AKT3A;PRKAR1B;CALM;PRKAA2;RAF1A |
| Thyroid hormone signaling pathway | PLCB1;MAPK1;MED27;MED12;SLC16A2;HRAS;ACTG1;ITGAV;PLCB3 |
| Insulin resistance | PRKCBA;SLC2A1A;INS;INSR;INSB;RPS6KA3;CD36;PTENB;PRKCDA |
| Pathways in cancer | Fasl;Fzd4;LPAR5;MAPK3;PIK3CB;F2RL3;Pdgfa&Pdgfb;GNG5;RUNX1T1 |
| Transcriptional misregulation in cancer | BCL2A1A;TMPRSS2;SIN3A;PDGFA;CD86;HIST1H3D;CCNT1;BCL2A1;ETV4 |
| Prostate cancer | CPN1;CCND1;KRAS;INS1;RELA;CREB3L1;BCL2;IKBKB;ARID1A |
FOXO1 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXO1 itself. We selected most functions FOXO1 had, and list some proteins which have the same functions with FOXO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXO3;SOX8A;SOX15;FOXB1;FOXJ1;SOX30;FOXJ3;ZNF215;OVOL3 |
| chromatin binding | HMGB2B;SP100;TRIM37;PATZ1;SMARCC1;CALCOCO1;HMGB3B;PAX3;JDP2 |
| protein binding | WNT3A;SLAMF1;PRDX6;ATP6V0D1;LEPROT;Kitl;EEF1E1;NOLC1;WBP2 |
| protein phosphatase 2A binding | SHC1;MASTL;FOXO1;AKT1;PPP2R2A;CPD;ENSAA;ENSA;SMG7 |
| sequence-specific DNA binding | GCM2;VDRB;IRX4B;NR1D4A;EVX1;RORAB;ZGPAT;HIVEP2A;DMBX1B |
| transcription factor activity, transcription factor binding | LDB2B;PER1;LDB1B;MTA2;LDB2A;TRP63;ASCL1;FOXO1;CRY1 |
| transcription factor binding | PIAS2;PURB;TCF12;HMGA1;TAF12;TAF7L;Ar;STK4;DNMT1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | PROX1;POU4F2;EN1;NKX6-2;KLF16;BCL11AB;HMGA2;MXD1;ZFP536 |
| ubiquitin protein ligase binding | UBE2T;CUL3;CUL2;TCEB2;RB1;DBT;MAGEC2;AICDA;UBE2C |
FOXO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXO1.
CDK1; FHL2; CCNB1; SET
- Q&As
- Reviews
Q&As (6)
Ask a questionFOXO1 is closely related to the study of gastric cancer, diabetes and cervical cancer.
FOXO1 is mainly expressed in fat, muscle and liver.
FOXO1 is an important mediator of the insulin signaling pathway, which is involved in a variety of biological processes including cell growth and metabolism.
FOXO1 is localized in the nucleus.
FOXO1 can bind the SREBP1 promoter and repress the transcriptional activity of SREBP1.
Overexpression of FOXO1 upregulates the expression of fatty acid transport-related genes and lipolytic genes, which inhibits lipid accumulation and reduces triglyceride content in the liver.
Customer Reviews (3)
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