Active Recombinant Full Length Human FOXO1 Protein, C-Flag-tagged

• Cat.No.: FOXO1-1038HFL
• Product Overview: Recombinant Full Length Human FOXO1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: In vitro kinase assay substrate
• Molecular Mass: 69.5 kDa
• AA Sequence: MAEAPQVVEIDPDFEPLPRPRSCTW PLPRPEFSQSNSATSSPAPSGSAAA NPDAAAGLPSASAAAVSADF MSNLSLLEESEDFPQAPGSVAAAVA AAAAAAATGGLCGDFQGPEAGCLHP APPQPPPPGPLSQHPPVPPA AAGPLAGQPRKSSSSRRNAWGNLSY ADLITKAIESSAEKRLTLSQIYEWM VKSVPYFKDKGDSNSSAGWK NSIRHNLSLHSKFIRVQNEGTGKSS WWMLNPEGGKSGKSPRRRAASMDNN SKFAKSRSRAAKKKASLQSG QEGAGDSPGSQFSKWPASPGSHSND DFDNWSTFRPRTSSNASTISGRLSP IMTEQDDLGEGDVHSMVYPP SAAKMASTLPSLSEISNPENMENLL DNLNLLSSPTSLTVSTQSSPGTMMQ QTPCYSFAPPNTSLNSPSPN YQKYTYGQSSMSPLPQMPIQTLQDN KSSYGGMSQYNCAPGLLKELLTSDS PPHNDIMTPVDPGVAQPNSR VLGQNVMMGPNSVMSTYGSQVSHNK MMNPSSHTHPGHAQQTSAVNGRPLP HTVSTMPHTSGMNRLTQVKT PVQVPLPHPMQMSALGGYSSVSSCN GYGRMGLLHQEKLPSDLDGMFIERL DCDMESIIRNDLMDGDTLDF
  NFDNVLPNQSFPHSVKTTTHSWVSG LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Insulin signaling pathway, Pathways in cancer, Prostate cancer

Gene Information

• Gene Name: FOXO1 forkhead box O1 [ Homo sapiens (human) ]
• Official Symbol: FOXO1
• Synonyms: FKH1; FKHR; FOXO1A
• Gene ID: 2308
• mRNA Refseq: NM_002015.4
• Protein Refseq: NP_002006.2
• MIM: 136533
• UniProt ID: Q12778