fut8
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  • Official Full Name
  • fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
  • Background
  • This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • FUT8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); alpha-(1,6)-fucosyltransferase; 6)-fucosyltransferase; 6-fucosyltransferase; Alpha (1,6) fucosyltransferase; Alpha-(1; Alpha1 6FucT; alpha1-6FucT; Fucosyltransferase 8; FUT8_HUMAN; GDP fucose glycoprotein fucosyltransferase; GDP L Fuc:N acetyl beta D glucosaminide alpha1,6 fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1; Glycoprotein 6 alpha L fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
Cat.#:FUT8-2659HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FUT8 Protein, MYC/DDK-tagged
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Cat.#:FUT8-4567HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FUT8 Protein, GST-tagged
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Cat.#:FUT8-577HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Fucosyltransferase 8 (alpha (1, 6) fucosyltransferase), His-tagged
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Cat.#:FUT8-2518HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FUT8, His tagged
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Cat.#:FUT8-27230THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FUT8
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Cat.#:Fut8-1413MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fut8 protein, His-tagged
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Cat.#:FUT8-6095MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FUT8 Protein
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Cat.#:FUT8-2415RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FUT8 Protein
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Cat.#:FUT8-1769RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FUT8 Protein, His-tagged
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Cat.#:FUT8-1237CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FUT8
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Cat.#:FUT8-326HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Hamster
Product nameRecombinant Hamster Fut8, His tagged
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Cat.#:FUT8-497HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FUT8 cell lysate
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Cat.#:FUT8-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Hamster
Product nameRecombinant Hamster FUT8 cell lysate
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Involved Pathway

FUT8 involved in several pathways and played different roles in them. We selected most pathways FUT8 participated on our site, such as N-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
N-Glycan biosynthesis
DPM3; DOLPP1; ST6GAL1; FUT8A; MOGS; MGAT1B; B4GALT3; ALG6; MAN1A; DPM1
Glycosaminoglycan biosynthesis - keratan sulfate
B4GALT1; B4GALT2; ST3GAL3; B3GNT1; B3GNT2B; CHST1; B3GNT7; CHST2A; B3GNT2; CHST4
Metabolic pathways
ANPEP; B3GNT4; NDUFS3; PTDSS1A; ATP6V0A2B; TCIRG1; ATP5O; CYP4A10; UQCRC1; GALK1
Transcriptional misregulation in cancer
GOLPH3; SS18; SPI1; MLLT1; TGFBR2; RUNX1; NTRK1; TCF3; ELK4; MEF2C

Protein Function

FUT8 has several biochemical functions, for example, SH3 domain binding, glycoprotein 6-alpha-L-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT8 itself. We selected most functions FUT8 had, and list some proteins which have the same functions with FUT8. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein TOM1L1; ABI2; DOCK1; PTTG2; PTPN12; SIRPA; MYPN; KHDRBS1; ADAM15; CCDC6
Function glycoprotein 6-alpha-L-fucosyltransferase activity
Related Protein FUT8A; FUT8

Interacting Protein

FUT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT8.
env; dAK1_1

FUT8 Related Articles

Li, WZ; Yu, R; et al. Core Fucosylation of IgG B Cell Receptor Is Required for Antigen Recognition and Antibody Production. JOURNAL OF IMMUNOLOGY 194:2596-2606(2015).
Wang, YQ; Fukuda, T; et al. Loss of alpha 1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling. SCIENTIFIC REPORTS 5:-(2015).