fxyd1
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  • Official Full Name
  • FXYD domain containing ion transport regulator 1
  • Background
  • This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described.
  • Synonyms
  • FXYD1; FXYD domain containing ion transport regulator 1; phospholemman , PLM; phospholemman; PLM; MGC44983
Cat.#:FXYD1-13054HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FXYD1, GST-tagged
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Cat.#:FXYD1-6103MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FXYD1 Protein
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Cat.#:FXYD1-2420RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FXYD1 Protein
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Cat.#:FXYD1-8130ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FXYD1
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Cat.#:FXYD1-6104HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FXYD1 293 Cell Lysate
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Cat.#:FXYD1-6105HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FXYD1 293 Cell Lysate
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Involved Pathway

Fxyd1 involved in several pathways and played different roles in them. We selected most pathways Fxyd1 participated on our site, such as cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fxyd1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
NPY1R; PPP1R12A; GNAI3; EP300; PRKACG; GHRL; PIK3CA; FXYD2; MAP2K1; PPP1CA

Protein Function

Fxyd1 has several biochemical functions, for example, ATPase binding, chloride channel activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fxyd1 itself. We selected most functions Fxyd1 had, and list some proteins which have the same functions with Fxyd1. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein NHP2L1; DRD1; PKD2; PTPN3; ATP1B3; SLC26A9; LCK; ATPIF1A; ATP6V0A1; GABARAPL2
Function chloride channel activity
Related Protein CLCN7; ANO2; GABRA5; SLC26A7; SLC26A4; TTYH2L; CLCA1; CLCA2; SLC26A1; SLC26A9
Function ion channel binding
Related Protein FKBP1B; CALM; DIAP1; RIMS1; HOMER1; SLC8A1; FYN; TRAPPC2; CHERP; FAM115A
Function myosin binding
Related Protein GIPC1; STX4A; SLC6A4; KIRREL; FXYD1; VETZ; ACTA1; MYBPC3; USH2A; VAMP2
Function sodium channel regulator activity
Related Protein SCN3B; PRSS30; SGK3; SCN1B; SCN2B; NOS1; FGF12; GPLD1; TMPRSS3; AGT

Fxyd1 Related Articles

Bibert, S; Liu, CC; et al. FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta(1) Subunit. JOURNAL OF BIOLOGICAL CHEMISTRY 286:18562-18572(2011).
Wang, JF; Gao, EH; et al. Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 300:H859-H868(2011).