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Fxyd1

  • Official Full Name

    FXYD domain containing ion transport regulator 1

  • Overview

    This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described.
  • Synonyms

    FXYD1; FXYD domain containing ion transport regulator 1; phospholemman , PLM; phospholemman; PLM; MGC44983;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FXYD1-13054H Recombinant Human FXYD1, GST-tagged E.coli GST 1-92a.a.
Human FXYD1-6104HCL Recombinant Human FXYD1 293 Cell Lysate HEK293 N/A
Human FXYD1-6105HCL Recombinant Human FXYD1 293 Cell Lysate HEK293 N/A
Human FXYD1-2996H Recombinant Human FXYD1 protein, His-tagged E.coli His 1-92 aa
Human FXYD1-3011H Recombinant Human FXYD1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse FXYD1-6103M Recombinant Mouse FXYD1 Protein Mammalian Cell His
Mouse FXYD1-3400M-B Recombinant Mouse FXYD1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fxyd1-3113M Recombinant Mouse Fxyd1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FXYD1-3400M Recombinant Mouse FXYD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FXYD1-2420R Recombinant Rat FXYD1 Protein Mammalian Cell His
Rat FXYD1-2076R Recombinant Rat FXYD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FXYD1-2076R-B Recombinant Rat FXYD1 Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL7228CF Recombinant Full Length Dog Phospholemman(Fxyd1) Protein, His-Tagged E.coli expression system His Full Length (21-92)
Homo sapiens (Human) RFL11242HF Recombinant Full Length Human Phospholemman(Fxyd1) Protein, His-Tagged E.coli expression system His Full Length (21-92)
Rattus norvegicus (Rat) RFL30010RF Recombinant Full Length Rat Phospholemman(Fxyd1) Protein, His-Tagged E.coli expression system His Full Length (21-92)
Zebrafish FXYD1-8130Z Recombinant Zebrafish FXYD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Fxyd1 Related Articles

Fxyd1 involved in several pathways and played different roles in them. We selected most pathways Fxyd1 participated on our site, such as cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fxyd1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayGRIA4;GLI3;ATP1A4;TSHR;PIK3CA;ATP1B1;GRIN1;CALM3;Adcy4

Fxyd1 has several biochemical functions, for example, ATPase binding, chloride channel activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fxyd1 itself. We selected most functions Fxyd1 had, and list some proteins which have the same functions with Fxyd1. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingTOR1AIP1;PIH1D1;NUFIP1;FBL;PEX19;ATP6V0A1;PDE4D;Ar;DRD1
chloride channel activitySLC26A5;SLC26A1;SLC26A4;CLCA3;SLC26A11;GABRE;CLCN5;CLIC3;SLC1A4
ion channel bindingRANGRF;PDE4D;KCNB2;KCNE4;KCNQ1;SCN5A;PDE4B;FGF13;DLG1
myosin bindingDMD;RHOA;ARFGEF1;USH2A;CALD1B;SLC6A4;VEZT;VETZ;STX4A
sodium channel regulator activitySCLT1;SGK2A;PTPN3;FGF12;PRSS30;FXYD4;GPD1L;SCN1B;SCN1BB

Fxyd1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fxyd1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fxyd1.

Bibert, S; Liu, CC; et al. FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta(1) Subunit. JOURNAL OF BIOLOGICAL CHEMISTRY 286:18562-18572(2011).
Wang, JF; Gao, EH; et al. Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 300:H859-H868(2011).
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