gab1
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  • Official Full Name
  • GAB1 GRB2-associated binding protein 1
  • Synonyms
  • GAB1; GRB2-associated binding protein 1; GRB2-associated-binding protein 1; GRB2-associated binder 1; growth factor receptor bound protein 2-associated protein 1;
Cat.#:GAB1-22HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAB1 Protein, T7/His-tagged
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Cat.#:GAB1-4618HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GAB1 Protein, GST-tagged
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Cat.#:GAB1-1450HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human GRB2-associated Binding Protein 1, His-tagged
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Cat.#:GAB1-1786HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAB1 protein, His & T7-tagged
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Cat.#:GAB1-27493THTag:His
Source (Host):Species:Human
Product nameRecombinant Human GAB1, His-tagged
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Cat.#:Gab1-1787MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gab1 protein, His & T7-tagged
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Cat.#:GAB1-1785RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GAB1 Protein, His-tagged
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Cat.#:GAB1-12537ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GAB1
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Cat.#:GAB1-6075HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GAB1 293 Cell Lysate
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Cat.#:GAB1-6076HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GAB1 293 Cell Lysate
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Involved Pathway

GAB1 involved in several pathways and played different roles in them. We selected most pathways GAB1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAB1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
ERBB4A; TGFA; PAK2; MAPK8; PAK4; BRAF; NRG2B; PTK2AA; MAPK9; PLCG2
Ras signaling pathway
FGF12; PRKACA; GNGT1; RAB5C; PDGFA; FGF1; NRAS; RAC2; FGF5; PAK3
Phospholipase D signaling pathway
MAPK1; LPAR6; RHOA; PIK3CB; PPAP2A; KIT; AGTR1A; TSC2; NRAS; PIK3R1
Neurotrophin signaling pathway
RPS6KA1; MAP2K1; BRAF; SH2B2; NGFR; PSEN2; PDPK1; ABL1; NTRK1; PIK3R2
Bacterial invasion of epithelial cells
SEPT3; SHC1; DNM1; SEPT6; WASL; CBLC; WAS; CLTA; ARPC4; CRKL
Proteoglycans in cancer
PLCG2; CDC42; DDX5; WNT5B; CBL; RRAS2; FGF2; DROSHA; CBLB; MAP2K2
Renal cell carcinoma
TGFB3; PIK3R5; EPAS1; PAK1; GAB1; PAK2; PAK6; EGLN1; EGLN2; GRB2

Protein Function

GAB1 has several biochemical functions, for example, SH3/SH2 adaptor activity, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAB1 itself. We selected most functions GAB1 had, and list some proteins which have the same functions with GAB1. You can find most of the proteins on our site.
Function
Related Protein
Function SH3/SH2 adaptor activity
Related Protein PTPN11; SH3BP2; CHN2; NCK1; STAM; CHN1; SHB; LASP1; GRB2; CRKL
Function protein binding
Related Protein CCDC88A; KCNE2; ZNF16; CRB1; WRNIP1; KCNA3; MBL2; ROPN1L; RRM2B; FAT4
Function signal transducer activity
Related Protein PTGER4C; LSP1; AIP; CBL; OLFR507; TAAR14H; OPN1SW1; PLCD3A; OLFR49; MALT1

Interacting Protein

GAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAB1.
PTPN11

GAB1 Related Articles

Pennacchietti, S; Cazzanti, M; et al. Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs. CANCER RESEARCH 74:6598-6609(2014).
Takeuchi, S; Wang, W; et al. Dual Inhibition of Met Kinase and Angiogenesis to Overcome HGF-Induced EGFR-TKI Resistance in EGFR Mutant Lung Cancer. AMERICAN JOURNAL OF PATHOLOGY 181:1034-1043(2012).