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GAB1

  • Official Full Name

    GAB1 GRB2-associated binding protein 1

  • Synonyms

    GAB1; GRB2-associated binding protein 1; GRB2-associated-binding protein 1; GRB2-associated binder 1; growth factor receptor bound protein 2-associated protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GAB1-27493TH Recombinant Human GAB1, His-tagged His
Human GAB1-1450H Recombinant Human GRB2-associated Binding Protein 1, His-tagged Sf9 Insect Cell His
Human GAB1-6076HCL Recombinant Human GAB1 293 Cell Lysate HEK293 N/A
Human GAB1-6075HCL Recombinant Human GAB1 293 Cell Lysate HEK293 N/A
Human GAB1-22H Recombinant Human GAB1 Protein, T7/His-tagged E. coli T7/His
Human GAB1-3003H Recombinant Human GAB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GAB1-5128HF Recombinant Full Length Human GAB1 Protein, GST-tagged In Vitro Cell Free System GST 724 amino acids
Human GAB1-4618H Recombinant Human GAB1 Protein, GST-tagged Wheat Germ GST
Human GAB1-3130H Recombinant Human GAB1 protein, His-tagged E.coli His 501-724 aa
Human GAB1-301484H Recombinant Human GAB1 protein, GST-tagged E.coli GST Thr120-Ala400
Human GAB1-1266HFL Recombinant Full Length Human GAB1 Protein, C-Flag-tagged Mammalian cells Flag
Human GAB1-1786H Recombinant Human GAB1 protein, His & T7-tagged E.coli His/T7 Asn394~Glu656 (Accession # Q13480)
Human GAB1-954H-B Recombinant Human GAB1 Protein Pre-coupled Magnetic Beads HEK293
Human GAB1-954H Recombinant Human GAB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GAB1-3040H Recombinant Human GAB1 Protein (Asn394-Arg656), N-His tagged E.coli N-His Asn394-Arg656
Mouse Gab1-3125M Recombinant Mouse Gab1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Gab1-1787M Recombinant Mouse Gab1 protein, His & T7-tagged E.coli His/T7 Pro356~His584 (Accession # Q9QYY0)
Rhesus Macaque GAB1-1785R Recombinant Rhesus monkey GAB1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GAB1-1606R Recombinant Rhesus Macaque GAB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GAB1-1606R-B Recombinant Rhesus Macaque GAB1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GAB1-12537Z Recombinant Zebrafish GAB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GAB1 Related Articles
  • GAB1 Related Signal Pathway

GAB1 involved in several pathways and played different roles in them. We selected most pathways GAB1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayNRAS;SRC;ABL1;PLCG1;CAMK2G;CBL;PRKCA;PRKCBB;CAMK2B1
Ras signaling pathwayFGF22;HTR7;KLK1B4;CALML3;PIK3R3;RASGRP3;INS;PAK2;NGFR
Phospholipase D signaling pathwayPLCB2;LPAR2;AGTR1A;SHC3;RRAS2;SHC2;Adcy4;PDGFA;PLA2G4C
Neurotrophin signaling pathwayCALM3;TRP53;MAPK11;NTRK2;RPS6KA3;MAPK8;MAPK9;MAPK10;NRAS
Bacterial invasion of epithelial cellsMET;CAV3;SEPT3;PIK3R5;ACTG1;ARPC1B;SEPT12;RAC1;CBL
Proteoglycans in cancerTGFB1;WNT5B;WNT7B;CD44;RPS6KB2;Ctsl;WNT4;HGF;PPP1R12C
Renal cell carcinomaTGFB1;EGLN1;EGLN2;FH1;EPAS1;HGF;KRAS;TGFA;VEGFA

GAB1 has several biochemical functions, for example, SH3/SH2 adaptor activity, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAB1 itself. We selected most functions GAB1 had, and list some proteins which have the same functions with GAB1. You can find most of the proteins on our site.

Function Related Protein
SH3/SH2 adaptor activityNCK1;GRB10;CRK;SRC;EPS8;CHN2;SOCS2;LAT;SH2D1A
protein bindingKCND2;CARD11;LASP1;VPS45;IL4;RPA2;ARL2BP;DSN1;NARG1
signal transducer activityOLFR181;GPR30;ADORA2AA;PLCB2;RERG;TAAR12J;OPN1SW2;HTR1AB;TAS2R109

GAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAB1.

PTPN11

Pennacchietti, S; Cazzanti, M; et al. Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs. CANCER RESEARCH 74:6598-6609(2014).
Takeuchi, S; Wang, W; et al. Dual Inhibition of Met Kinase and Angiogenesis to Overcome HGF-Induced EGFR-TKI Resistance in EGFR Mutant Lung Cancer. AMERICAN JOURNAL OF PATHOLOGY 181:1034-1043(2012).
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