Recombinant Full Length Human GAB1 Protein, C-Flag-tagged

• Cat.No.: GAB1-1266HFL
• Product Overview: Recombinant Full Length Human GAB1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 79.8 kDa
• AA Sequence: MSGGEVVCSGWLRKSPPEKKLKRYA WKRRWFVLRSGRLTGDPDVLEYYKN DHAKKPIRIIDLNLCQQVDA GLTFNKKEFENSYIFDINTIDRIFY LVADSEEEMNKWVRCICDICGFNPT EEDPVKPPGSSLQAPADLPL AINTAPPSTQADSSSATLPPPYQLI NVPPHLETLGIQEDPQDYLLLINCQ SKKPEPTRTHADSAKSTSSE TDCNDNVPSHKNPASSQSKHGMNGF FQQQMIYDSPPSRAPSASVDSSLYN LPRSYSHDVLPKVSPSSTEA DGELYVFNTPSGTSSVETQMRHVSI SYDIPPTPGNTYQIPRTFPEGTLGQ TSKLDTIPDIPPPRPPKPHP AHDRSPVETCSIPRTASDTDSSYCI PTAGMSPSRSNTISTVDLNKLRKDA SSQDCYDIPRAFPSDRSSSL EGFHNHFKVKNVLTVGSVSSEELDE NYVPMNPNSPPRQHSSSFTEPIQEA NYVPMTPGTFDFSSFGMQVP PPAHMGFRSSPKTPPRRPVPVADCE PPPVDRNLKPDRKGQSPKILRLKPH GLERTDSQTIGDFATRRKVK PAPLEIKPLPEWEELQAPVRSPITR SFARDSSRFPMSPRPDSVHSTTSSS DSHDSEENYVPMNPNLSSED PNLFGSNSLDGGSSPMIKPKGDKQV EYLDLDLDSGKSTPPRKQKSSGSGS SVADERVDYVVVDQQKTLAL
  KSTREAWTDGRQSTESETPAKSVKT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: ErbB signaling pathway, Neurotrophin signaling pathway, Renal cell carcinoma

Gene Information

• Gene Name: GAB1 GRB2 associated binding protein 1 [ Homo sapiens (human) ]
• Official Symbol: GAB1
• Synonyms: DFNB26
• Gene ID: 2549
• mRNA Refseq: NM_207123.3
• Protein Refseq: NP_997006.1
• MIM: 604439
• UniProt ID: Q13480