gba
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  • Official Full Name
  • glucosidase, beta, acid
  • Background
  • This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • GBA; glucosidase, beta, acid; GLUC, glucosidase, beta; acid (includes glucosylceramidase) , glucosylceramidase; glucosylceramidase; GBA1; alglucerase; imiglucerase; acid beta-glucosidase; beta-glucocerebrosidase; lysosomal glucocerebrosidase; D-glucosyl
Cat.#:GBA-539HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GBA Protein (Ala40-Gln536), His-tagged
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Cat.#:GBA-4764HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GBA Protein, GST-tagged
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Cat.#:GBA-020HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GBA, MYC/DDK-tagged
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Cat.#:GBA-178HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GBA protein, MYC/DDK-tagged
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Cat.#:GBA-179HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GBA protein, MYC/DDK-tagged
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Cat.#:GBA-180HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GBA protein, MYC/DDK-tagged
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Cat.#:GBA-181HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GBA protein, MYC/DDK-tagged
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Cat.#:GBA-182HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GBA protein, MYC/DDK-tagged
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Cat.#:GBA-198HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GBA protein, His-tagged
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Cat.#:GBA-22HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GBA, His-tagged
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Cat.#:GBA-28984THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GBA
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Cat.#:GBA-28HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human GBA protein, His-tagged
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Cat.#:GBA-7841HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GBA protein, His-tagged
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Cat.#:GBA-6235MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GBA Protein
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Cat.#:Gba-7842MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gba protein, His & GST-tagged
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Cat.#:Gba-7843RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gba protein, His & GST-tagged
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Cat.#:GBA-6002HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GBA 293 Cell Lysate
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Cat.#:GBA-P024HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GBA therapeutic protein
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Cat.#:GBA-P028HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GBA therapeutic protein
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Cat.#:GBA-P034HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GBA therapeutic protein
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Cat.#:GBA-P047HTag:N/A
Source (Host):N/ASpecies:Human
Product nameRecombinant Human GBA therapeutic protein
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Involved Pathway

GBA involved in several pathways and played different roles in them. We selected most pathways GBA participated on our site, such as Other glycan degradation, Sphingolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Other glycan degradation
MAN2C1; HEXDC; GLB1; FUCA2; ENG-1; NEU2; NEU3.1; FUCA1.2; NEU3.2; NEU4
Sphingolipid metabolism
ARSD; VAPB; GLA; NEU3.3; CERS4A; SPTLC1; UGT8; LASS1; ARSA; SGMS2
Metabolic pathways
UGT1A6; HSD11B1; AMY2A; PCYT1BB; CYP51A1; GALCA; GAD1B; MGAT1B; C1GALT1C1; GAA
Lysosome
SLC11A2; GALCB; AP1M1; SLC17A5; AP4E1; CTSSA; M6PR; AP1G2; ASAH1A; GALNS

Protein Function

GBA has several biochemical functions, for example, glucosylceramidase activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GBA itself. We selected most functions GBA had, and list some proteins which have the same functions with GBA. You can find most of the proteins on our site.
Function
Related Protein
Function glucosylceramidase activity
Related Protein GBA2; GBA
Function protein binding
Related Protein COL3A1; LRRFIP2; ZNF224; RAD51D; RPL28; TBC1D24; SLC35F6; CCAR1; FKBP1A; HEYL
Function receptor binding
Related Protein ABL2; FGF10A; BMP2; APOF; MCHR1; PEX14; TNFSF13; TAC4; CADM2; POMC

Interacting Protein

GBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBA here. Most of them are supplied by our site. Hope this information will be useful for your research of GBA.
Scarb2; pi3p; SCAMP3; TOP3B; A2M; cona_canen; HSPD1; HSP90B1; ATP5J; CANX; ATP6V1A; SKIV2L2; CCT3; CCT8; RPS6KA3; FMR1; ZMYND11; DHCR24; RNF20; ZCCHC8

GBA Related Articles

Sinclair, G; Pfeifer, TA; et al. Secretion of human glucocerebrosidase from stable transformed insect cells using native signal sequences. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 84:148-156(2006).
Favalli, EG; Varenna, M; et al. Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 23:247-250(2005).